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Multicenter validat...
Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS
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Oeckl, Patrick (author)
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Jardel, Claude (author)
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Salachas, Francois (author)
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Lamari, Foudil (author)
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- Andersen, Peter M. (author)
- Umeå universitet,Klinisk neurovetenskap
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Bowser, Robert (author)
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de Carvalho, Mamede (author)
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Costa, Julia (author)
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van Damme, Philip (author)
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Gray, Elizabeth (author)
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Grosskreutz, Julian (author)
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Hernandez-Barral, Maria (author)
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Herukka, Sanna-Kaisa (author)
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Huss, Andre (author)
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Jeromin, Andreas (author)
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Kirby, Janine (author)
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Kuzma-Kozakiewicz, Magdalena (author)
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Amador, Maria del Mar (author)
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Mora, Jesus S. (author)
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Morelli, Claudia (author)
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Muckova, Petra (author)
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Petri, Susanne (author)
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Poesen, Koen (author)
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Rhode, Heidrun (author)
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- Rikardsson, Anna-Karin (author)
- Umeå universitet,Klinisk neurovetenskap
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Robberecht, Wim (author)
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Rodriguez Mahillo, Ana I. (author)
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Shaw, Pamela (author)
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Silani, Vincenzo (author)
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Steinacker, Petra (author)
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Turner, Martin R. (author)
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Tuzun, Erdem (author)
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Yetimler, Berrak (author)
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Ludolph, Albert C. (author)
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Otto, Markus (author)
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(creator_code:org_t)
- 2016-04-11
- 2016
- English.
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In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - : Informa UK Limited. - 2167-8421 .- 2167-9223. ; 17:5-6, s. 404-413
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- OBJECTIVE: Neurofilaments are leading neurochemical biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigated the effect of preanalytical factors on neurofilament concentrations in cerebrospinal fluid (CSF) in a reverse round-robin with 15 centers across Europe/U.S. METHODS: Samples from ALS and control patients (5/5 each center, n=150) were analyzed for phosphorylated neurofilament heavy chain (pNfH) and neurofilament light chain (NfL) at two laboratories. RESULTS: CSF pNfH was increased (p<0.05) in ALS in 10 out of 15 centers and NfL in 5 out of 12 centers. The coefficient of variation (CV%) of pNfH measurements between laboratories was 18.7 +/- 19.1%. We calculated a diagnostic cut-off of >568.5pg/mL for pNfH (sensitivity 78.7%, specificity 93.3%) and >1,431pg/mL for NfL (sensitivity 79.0%, specificity 86.4%). CONCLUSION: Values in ALS patients are already comparable between most centers, supporting eventual implementation into clinical routine. However, continuous quality control programs will be necessary for inclusion in the diagnostic work-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Cerebrospinal fluid
- neurofilament
- biomarker
- amyotrophic lateral sclerosis
- round robin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Oeckl, Patrick
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Jardel, Claude
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Salachas, Franco ...
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Lamari, Foudil
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Andersen, Peter ...
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Bowser, Robert
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show more...
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de Carvalho, Mam ...
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Costa, Julia
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van Damme, Phili ...
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Gray, Elizabeth
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Grosskreutz, Jul ...
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Hernandez-Barral ...
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Herukka, Sanna-K ...
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Huss, Andre
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Jeromin, Andreas
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Kirby, Janine
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Kuzma-Kozakiewic ...
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Amador, Maria de ...
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Mora, Jesus S.
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Morelli, Claudia
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Muckova, Petra
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Petri, Susanne
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Poesen, Koen
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Rhode, Heidrun
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Rikardsson, Anna ...
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Robberecht, Wim
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Rodriguez Mahill ...
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Shaw, Pamela
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Silani, Vincenzo
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Steinacker, Petr ...
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Turner, Martin R ...
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Tuzun, Erdem
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Yetimler, Berrak
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Ludolph, Albert ...
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Otto, Markus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Amyotrophic Late ...
- By the university
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Umeå University