Search: WFRF:(Delfau Larue Marie Helene)
> Pott Christiane >
Is there a role for...
Is there a role for antigen selection in mantle cell lymphoma? : Immunogenetic support from a series of 807 cases
-
Hadzidimitriou, Anastasia (author)
-
Agathangelidis, Andreas (author)
-
Darzentas, Nikos (author)
-
show more...
-
- Murray, Fiona (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
Delfau-Larue, Marie-Helene (author)
-
Pedersen, Lone Bredo (author)
-
Navarro Lopez, Alba (author)
-
Dagklis, Antonis (author)
-
Rombout, Paul (author)
-
Beldjord, Kheira (author)
-
Kolstad, Arne (author)
-
Dreyling, Martin H. (author)
-
Anagnostopoulos, Achilles (author)
-
Tsaftaris, Athanasios (author)
-
Mavragani-Tsipidou, Penelope (author)
-
Rosenwald, Andreas (author)
-
Ponzoni, Maurilio (author)
-
Groenen, Patricia (author)
-
Ghia, Paolo (author)
-
- Sander, Birgitta (author)
- Karolinska Institutet
-
Papadaki, Theodora (author)
-
Campo, Elias (author)
-
Geisler, Christian (author)
-
- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
Davi, Frederic (author)
-
Pott, Christiane (author)
-
Stamatopoulos, Kostas (author)
-
show less...
-
(creator_code:org_t)
- American Society of Hematology, 2011
- 2011
- English.
-
In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 118:11, s. 3088-3095
- Related links:
-
https://ashpublicati...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- We examined 807 productive IGHV-IGHD-IGHJ gene rearrangements from mantle cell lymphoma (MCL) cases, by far the largest series to date. The IGHV gene repertoire was remarkably biased, with IGHV3-21, IGHV4-34, IGHV1-8, and IGHV3-23 accounting for 46.3% of the cohort. Eighty-four of 807 (10.4%) cases, mainly using the IGHV3-21 and IGHV4-34 genes, were found to bear stereotyped heavy complementarity-determining region 3 (VH CDR3) sequences and were placed in 38 clusters. Notably, the MCL stereotypes were distinct from those reported for chronic lymphocytic leukemia. Based on somatic hypermutation (SHM) status, 238/807 sequences (29.5%) carried IGHV genes with 100% germ line identity; the remainder (569/807; 70.5%) exhibited different SHM impact, ranging from minimal (in most cases) to pronounced. Shared replacement mutations across the IGHV gene were identified for certain subgroups, especially those using IGHV3-21, IGHV1-8, and IGHV3-23. Comparison with other entities, in particular CLL, revealed that several of these mutations were "MCL-biased." In conclusion, MCL is characterized by a highly restricted immunoglobulin gene repertoire with stereotyped VH CDR3s and very precise SHM targeting, strongly implying a role for antigen-driven selection of the clonogenic progenitors. Hence, an antigen-driven origin of MCL could be envisaged, at least for subsets of cases.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Blood
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Hadzidimitriou, ...
-
Agathangelidis, ...
-
Darzentas, Nikos
-
Murray, Fiona
-
Delfau-Larue, Ma ...
-
Pedersen, Lone B ...
-
show more...
-
Navarro Lopez, A ...
-
Dagklis, Antonis
-
Rombout, Paul
-
Beldjord, Kheira
-
Kolstad, Arne
-
Dreyling, Martin ...
-
Anagnostopoulos, ...
-
Tsaftaris, Athan ...
-
Mavragani-Tsipid ...
-
Rosenwald, Andre ...
-
Ponzoni, Maurili ...
-
Groenen, Patrici ...
-
Ghia, Paolo
-
Sander, Birgitta
-
Papadaki, Theodo ...
-
Campo, Elias
-
Geisler, Christi ...
-
Rosenquist, Rich ...
-
Davi, Frederic
-
Pott, Christiane
-
Stamatopoulos, K ...
-
show less...
- Articles in the publication
-
Blood
- By the university
-
Uppsala University
-
Karolinska Institutet