Sökning: WFRF:(Dhadda A)
> Ellis Richard >
SCOT :
SCOT : a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer
-
- Robles-Zurita, Jose (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
-
- Boyd, Kathleen A. (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
-
- Briggs, Andrew H. (författare)
- Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
-
visa fler...
-
- Iveson, Timothy (författare)
- Southampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
-
- Kerr, Rachel S. (författare)
- Univ Oxford, Dept Oncol, Oxford, England
-
- Saunders, Mark P. (författare)
- Christie Hosp, Manchester, Lancs, England
-
- Cassidy, Jim (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
-
- Hollander, Niels Henrik (författare)
- Zealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark
-
- Tabernero, Josep (författare)
- Univ Autonoma Barcelona, CIBERONC, Vall dHebron Univ Hosp, Barcelona, Spain;Univ Autonoma Barcelona, CIBERONC, Inst Oncol VHIO, Barcelona, Spain
-
- Segelov, Eva (författare)
- Australasian Gastrointestinal Trials Grp AGITG, Melbourne, Vic, Australia;Monash Univ, Melbourne, Vic, Australia;Monash Hlth, Melbourne, Vic, Australia
-
- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
-
- Harkin, Andrea (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
-
- Allan, Karen (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
-
- McQueen, John (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
-
- Pearson, Sarah (författare)
- Univ Oxford, OCTO, Dept Oncol, Oxford, England
-
- Waterston, Ashita (författare)
- Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland
-
- Medley, Louise (författare)
- Royal United Hosp, Bath, Avon, England
-
- Wilson, Charles (författare)
- Addenbrookes Hosp, Cambridge, England
-
- Ellis, Richard (författare)
- Royal Cornwall Hosp NHS Trust, Truro, Cornwall, England
-
- Essapen, Sharadah (författare)
- Royal Surrey Cty Hosp NHS Fdn Trust, St Lukes Canc Ctr, Guildford, Surrey, England
-
- Dhadda, Amandeep S. (författare)
- Castle Hill Hosp, Kingston Upon Hull, N Humberside, England
-
- Hughes, Rob (författare)
- Mt Vernon Canc Ctr, Northwood, Middx, England
-
- Falk, Stephen (författare)
- Bristol Canc Inst, Bristol, Avon, England
-
- Raouf, Sherif (författare)
- Barking Havering & Redbridge Univ Hosp NHS Trust, Barking, England
-
- Rees, Charlotte (författare)
- Southampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
-
- Olesen, Rene K. (författare)
- Zealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark
-
- Propper, David (författare)
- Queen Mary Univ London, Barts Canc Inst, London, England
-
- Bridgewater, John (författare)
- UCL, London, England
-
- Azzabi, Ashraf (författare)
- Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England
-
- Farrugia, David (författare)
- Cheltenham Gen Hosp, Gloucestershire Oncol Ctr, Cheltenham, Glos, England
-
- Webb, Andrew (författare)
- Brighton & Sussex Univ Hosp Trust, Brighton, E Sussex, England
-
- Cunningham, David (författare)
- Royal Marsden, London, England
-
- Hickish, Tamas (författare)
- Bournemouth Univ, Poole Hosp, Bournemouth, Dorset, England
-
- Weaver, Andrew (författare)
- Oxford Univ Hosp Fdn Trust, Churchill Hosp, Oxford, England
-
- Gollins, Simon (författare)
- North Wales Canc Treatment Ctr, Rhyl, Wales
-
- Wasan, Harpreet S. (författare)
- Imperial Coll London, Hammersmith Hosp, London, England
-
- Paul, James (författare)
- Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
-
visa färre...
-
(creator_code:org_t)
- 2018-11-13
- 2018
- Engelska.
-
Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 119:11, s. 1332-1338
- Relaterad länk:
-
https://www.nature.c...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.METHODS: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Quality-adjusted partitioned survival analysis and Kaplan-Meier Sample Average Estimator estimated QALYs and costs. Probabilistic sensitivity and subgroup analysis was undertaken.RESULTS: The 3M arm is less costly (-4881; pound 95% CI: -6269; pound -3492) pound and entails (non-significant) QALY gains (0.08; 95% CI: -0.086; 0.230) due to a better significant quality of life. The net monetary benefit was significantly higher in 3M under a wide range of monetary values of a QALY. The subgroup analysis found similar results for patients in the CAPOX regimen. However, for the FOLFOX regimen, 3M had lower QALYs than 6M (not statistically significant).CONCLUSIONS: Overall, 3M dominates 6M with no significant detrimental impact on QALYs. The results provide the economic case that a 3M treatment strategy should be considered a new standard of care.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Robles-Zurita, J ...
-
Boyd, Kathleen A ...
-
Briggs, Andrew H ...
-
Iveson, Timothy
-
Kerr, Rachel S.
-
Saunders, Mark P ...
-
visa fler...
-
Cassidy, Jim
-
Hollander, Niels ...
-
Tabernero, Josep
-
Segelov, Eva
-
Glimelius, Bengt
-
Harkin, Andrea
-
Allan, Karen
-
McQueen, John
-
Pearson, Sarah
-
Waterston, Ashit ...
-
Medley, Louise
-
Wilson, Charles
-
Ellis, Richard
-
Essapen, Sharada ...
-
Dhadda, Amandeep ...
-
Hughes, Rob
-
Falk, Stephen
-
Raouf, Sherif
-
Rees, Charlotte
-
Olesen, Rene K.
-
Propper, David
-
Bridgewater, Joh ...
-
Azzabi, Ashraf
-
Farrugia, David
-
Webb, Andrew
-
Cunningham, Davi ...
-
Hickish, Tamas
-
Weaver, Andrew
-
Gollins, Simon
-
Wasan, Harpreet ...
-
Paul, James
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
British Journal ...
- Av lärosätet
-
Uppsala universitet