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Genetic determinant...
Genetic determinants of heel bone properties : genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
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Moayyeri, Alireza (author)
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Hsu, Yi-Hsiang (author)
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Karasik, David (author)
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show more...
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Estrada, Karol (author)
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Xiao, Su-Mei (author)
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Nielson, Carrie (author)
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Srikanth, Priya (author)
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Giroux, Sylvie (author)
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Wilson, Scott G. (author)
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Zheng, Hou-Feng (author)
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Smith, Albert V. (author)
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Pye, Stephen R. (author)
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Leo, Paul J. (author)
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Teumer, Alexander (author)
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Hwang, Joo-Yeon (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine
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- McGuigan, Fiona (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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Minster, Ryan L. (author)
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Hayward, Caroline (author)
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Olmos, Jose M. (author)
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Lyytikaeinen, Leo-Pekka (author)
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Lewis, Joshua R. (author)
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Swart, Karin M. A. (author)
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Masi, Laura (author)
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Oldmeadow, Chris (author)
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Holliday, Elizabeth G. (author)
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Cheng, Sulin (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine
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Harvey, Nicholas C. (author)
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Kruk, Marcin (author)
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Fabiola Del Greco, M. (author)
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Igl, Wilmar (author)
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Trummer, Olivia (author)
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Grigoriou, Efi (author)
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Luben, Robert (author)
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Liu, Ching-Ti (author)
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Zhou, Yanhua (author)
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Oei, Ling (author)
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Medina-Gomez, Carolina (author)
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Zmuda, Joseph (author)
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Tranah, Greg (author)
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Brown, Suzanne J. (author)
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Williams, Frances M. (author)
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Soranzo, Nicole (author)
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Jakobsdottir, Johanna (author)
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Siggeirsdottir, Kristin (author)
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Holliday, Kate L. (author)
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Hannemann, Anke (author)
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Go, Min Jin (author)
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Garcia, Melissa (author)
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Polasek, Ozren (author)
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Laaksonen, Marika (author)
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Zhu, Kun (author)
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Enneman, Anke W. (author)
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McEvoy, Mark (author)
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Peel, Roseanne (author)
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Sham, Pak Chung (author)
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Jaworski, Maciej (author)
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Johansson, Asa (author)
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Hicks, Andrew A. (author)
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Pludowski, Pawel (author)
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Scott, Rodney (author)
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Dhonukshe-Rutten, Rosalie A. M. (author)
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van der Velde, Nathalie (author)
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Kaehoenen, Mika (author)
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Viikari, Jorma S. (author)
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Sievaenen, Harri (author)
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Raitakari, Olli T. (author)
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Gonzalez-Macias, Jesus (author)
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Hernandez, Jose L. (author)
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Mellstroem, Dan (author)
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- Ljunggren, Östen (author)
- Uppsala universitet,Endokrinologi och mineralmetabolism
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Cho, Yoon Shin (author)
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Voelker, Uwe (author)
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Nauck, Matthias (author)
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Homuth, Georg (author)
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Voelzke, Henry (author)
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Haring, Robin (author)
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Brown, Matthew A. (author)
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McCloskey, Eugene (author)
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Nicholson, Geoffrey C. (author)
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Eastell, Richard (author)
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Eisman, John A. (author)
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Jones, Graeme (author)
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Reid, Ian R. (author)
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Dennison, Elaine M. (author)
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Wark, John (author)
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Boonen, Steven (author)
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Vanderschueren, Dirk (author)
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Wu, Frederick C. W. (author)
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Aspelund, Thor (author)
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Richards, J. Brent (author)
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Bauer, Doug (author)
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Hofman, Albert (author)
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Khaw, Kay-Tee (author)
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Dedoussis, George (author)
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Obermayer-Pietsch, Barbara (author)
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Gyllensten, Ulf (author)
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Pramstaller, Peter P. (author)
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Lorenc, Roman S. (author)
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Cooper, Cyrus (author)
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Kung, Annie Wai Chee (author)
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Lips, Paul (author)
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Alen, Markku (author)
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Attia, John (author)
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Luisa Brandi, Maria (author)
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de Groot, Lisette C. P. G. M. (author)
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Lehtimaeki, Terho (author)
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Riancho, Jose A. (author)
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Campbell, Harry (author)
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Liu, Yongmei (author)
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Harris, Tamara B. (author)
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- Åkesson, Kristina (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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Lee, Jong-Young (author)
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Wallaschofski, Henri (author)
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Duncan, Emma L. (author)
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O'Neill, Terence W. (author)
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Gudnason, Vilmundur (author)
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Spector, Timothy D. (author)
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Rousseau, Francois (author)
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Orwoll, Eric (author)
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Cummings, Steven R. (author)
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Wareham, Nick J. (author)
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Rivadeneira, Fernando (author)
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Uitterlinden, Andre G. (author)
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Prince, Richard L. (author)
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Kiel, Douglas P. (author)
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Reeve, Jonathan (author)
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Kaptoge, Stephen K. (author)
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(creator_code:org_t)
- 2014-01-14
- 2014
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:11, s. 3054-3068
- Related links:
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https://academic.oup...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 x 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 x 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 x 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- X-RAY ABSORPTIOMETRY
- QUANTITATIVE ULTRASOUND
- MINERAL DENSITY
- OSTEOPOROSIS
- FRACTURE
- RISK
- DENSITOMETRY
- PHENOTYPES
- CALCANEUS
- WOMEN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Moayyeri, Alirez ...
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Hsu, Yi-Hsiang
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Karasik, David
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Estrada, Karol
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Xiao, Su-Mei
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Nielson, Carrie
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show more...
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Srikanth, Priya
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Giroux, Sylvie
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Wilson, Scott G.
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Zheng, Hou-Feng
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Smith, Albert V.
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Pye, Stephen R.
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Leo, Paul J.
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Teumer, Alexande ...
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Hwang, Joo-Yeon
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Ohlsson, Claes, ...
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McGuigan, Fiona
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Minster, Ryan L.
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Hayward, Carolin ...
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Olmos, Jose M.
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Lyytikaeinen, Le ...
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Lewis, Joshua R.
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Swart, Karin M. ...
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Masi, Laura
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Oldmeadow, Chris
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Holliday, Elizab ...
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Cheng, Sulin
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Mellström, Dan, ...
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Harvey, Nicholas ...
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Kruk, Marcin
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Fabiola Del Grec ...
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Igl, Wilmar
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Trummer, Olivia
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Grigoriou, Efi
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Luben, Robert
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Liu, Ching-Ti
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Zhou, Yanhua
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Oei, Ling
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Medina-Gomez, Ca ...
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Zmuda, Joseph
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Tranah, Greg
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Brown, Suzanne J ...
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Williams, France ...
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Soranzo, Nicole
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Jakobsdottir, Jo ...
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Siggeirsdottir, ...
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Holliday, Kate L ...
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Hannemann, Anke
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Go, Min Jin
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Garcia, Melissa
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Polasek, Ozren
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Laaksonen, Marik ...
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Zhu, Kun
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Enneman, Anke W.
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McEvoy, Mark
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Peel, Roseanne
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Sham, Pak Chung
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Jaworski, Maciej
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Johansson, Asa
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Hicks, Andrew A.
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Pludowski, Pawel
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Scott, Rodney
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Dhonukshe-Rutten ...
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van der Velde, N ...
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Kaehoenen, Mika
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Viikari, Jorma S ...
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Sievaenen, Harri
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Raitakari, Olli ...
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Gonzalez-Macias, ...
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Hernandez, Jose ...
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Mellstroem, Dan
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Ljunggren, Östen
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Cho, Yoon Shin
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Voelker, Uwe
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Nauck, Matthias
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Homuth, Georg
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Voelzke, Henry
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Haring, Robin
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Brown, Matthew A ...
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McCloskey, Eugen ...
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Nicholson, Geoff ...
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Eastell, Richard
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Eisman, John A.
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Jones, Graeme
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Reid, Ian R.
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Dennison, Elaine ...
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Wark, John
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Boonen, Steven
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Vanderschueren, ...
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Wu, Frederick C. ...
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Aspelund, Thor
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Richards, J. Bre ...
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Bauer, Doug
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Hofman, Albert
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Khaw, Kay-Tee
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Dedoussis, Georg ...
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Obermayer-Pietsc ...
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Gyllensten, Ulf
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Pramstaller, Pet ...
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Lorenc, Roman S.
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Cooper, Cyrus
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Kung, Annie Wai ...
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Lips, Paul
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Alen, Markku
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Attia, John
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Luisa Brandi, Ma ...
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de Groot, Lisett ...
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Lehtimaeki, Terh ...
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Riancho, Jose A.
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Campbell, Harry
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Liu, Yongmei
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Harris, Tamara B ...
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Åkesson, Kristin ...
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Karlsson, Magnus
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Lee, Jong-Young
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Wallaschofski, H ...
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Duncan, Emma L.
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O'Neill, Terence ...
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Gudnason, Vilmun ...
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Spector, Timothy ...
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Rousseau, Franco ...
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Orwoll, Eric
-
Cummings, Steven ...
-
Wareham, Nick J.
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Rivadeneira, Fer ...
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Uitterlinden, An ...
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Prince, Richard ...
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Kiel, Douglas P.
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Reeve, Jonathan
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Kaptoge, Stephen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Human Molecular ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg