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Träfflista för sökning "WFRF:(Dominiczak Anna) srt2:(2010-2014);pers:(Viigimaa Margus)"

Sökning: WFRF:(Dominiczak Anna) > (2010-2014) > Viigimaa Margus

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Numrering	Referens	Omslagsbild	Hitta
1.	Johnson, Toby, et al. (författare) Blood Pressure Loci Identified with a Gene-Centric Array. 2011 Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 89:6, s. 688-700 Tidskriftsartikel (refereegranskat)abstract Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56× 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56× 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.
2.	Mancia, Giuseppe, et al. (författare) 2013 ESH/ESC Guidelines for the management of arterial hypertension 2013 Ingår i: European Heart Journal. - : Oxford University Press (OUP): Policy B. - 0195-668X .- 1522-9645. ; 34:28, s. - Tidskriftsartikel (refereegranskat)abstract n/a
3.	Mancia, Giuseppe, et al. (författare) 2013 ESH/ESC guidelines for the management of arterial hypertension : the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). 2013 Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:28, s. 2159-2219 Tidskriftsartikel (refereegranskat)
4.	Mancia, Giuseppe, et al. (författare) 2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension 2014 Ingår i: Blood Pressure. - : Informa Healthcare. - 0803-7051 .- 1651-1999. ; 23:1, s. 3-16 Tidskriftsartikel (refereegranskat)abstract n/a
5.	Mancia, Giuseppe, et al. (författare) 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) 2013 Ingår i: Journal of Hypertension. - : Lippincott, Williams and Wilkins. - 0263-6352 .- 1473-5598. ; 31:10, s. 1925-1938 Tidskriftsartikel (refereegranskat)abstract n/a
6.	Mancia, Giuseppe, et al. (författare) 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. 2013 Ingår i: Journal of Hypertension. - 1473-5598. ; 31:10, s. 1925-1938 Tidskriftsartikel (refereegranskat)
7.	Olsen, Michael H., et al. (författare) Agreement within Europe about antihypertensive treatment and education - results from the European Society of Hypertension questionnaire 2010 Ingår i: Journal of Hypertension. - 1473-5598. ; 28:7, s. 1593-1594 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
8.	Zanchetti, Alberto, et al. (författare) Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. 2014 Ingår i: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1888-1897 Tidskriftsartikel (refereegranskat)abstract The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design.
9.	Zanchetti, Alberto, et al. (författare) Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. 2014 Ingår i: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1741-1750 Forskningsöversikt (refereegranskat)abstract It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.

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Resultat 1-9 av 9

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Typ av publikation: tidskriftsartikel (8); forskningsöversikt (1)

Typ av innehåll: refereegranskat (8); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Viigimaa, Margus (9)Ta bort avgränsningen; Laurent, Stephane (8); Cifkova, Renata (8); Narkiewicz, Krzyszto ... (8); Mancia, Giuseppe (8); Schmieder, Roland E. (8); visa fler...; Dominiczak, Anna (8); Zanchetti, Alberto (8); Redon, Josep (7); Manolis, Athanasios ... (7); Nilsson, Peter (6); Kjeldsen, Sverre E. (6); Ruilope, Luis Miguel (6); Jaarsma, Tiny (5); Zannad, Faiez (5); Sleight, Peter (5); Galderisi, Maurizio (5); De Backer, Guy (5); Fagard, Robert (5); Grobbee, Diederick E ... (5); Sirnes, Per Anton (5); Christiaens, Thierry (5); Waeber, Bernard (5); Erdine, Serap (4); Coca, Antonio (3); Boehm, Michael (3); Kirchhof, Paulus (3); Parati, Gianfranco (3); Burnier, Michel (3); Lovic, Dragan (3); Agabiti-Rosei, Enric ... (3); Farsang, Csaba (3); Nilsson, Peter M (2); Rodicio, Jose Luis (2); Silani, Vincenzo (2); Berge, Eivind (2); Böhm, Michael (2); Zhang, Yuqing (2); Pinto, Fernando (2); Banach, Maciej (2); Dicker, Dror (2); O'Brien, John (2); Zambon, Antonella (2); Corrao, Giovanni (2); Jelakovic, Bojan (2); Scotti, Lorenza (2); Liu, Lisheng (2); Grassi, Guido (2); Zhu, Dingliang (2); Stramba-Badiale, Mar ... (2); visa färre...

Lärosäte: Lunds universitet (7); Linköpings universitet (3); Karolinska Institutet (2); Göteborgs universitet (1)Ta bort avgränsningen; Linnéuniversitetet (1)

Språk: Engelska (9)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (8)

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