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Träfflista för sökning "WFRF:(Dominiczak Anna) srt2:(2015-2019);pers:(Wilson James F.)"

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1.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
2.	Nüesch, Eveline, et al. (author) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. 2016 In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 45:6, s. 1927-1937 Journal article (peer-reviewed)abstract We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.
3.	van Setten, Jessica, et al. (author) PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity 2018 In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9 Journal article (peer-reviewed)abstract Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are overrepresented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of similar to 105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ionchannel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Dominiczak, Anna F. (3); Wilson, James F. (3)Undo refine; Asselbergs, Folkert ... (3); März, Winfried (2); Raitakari, Olli T (2); Campbell, Harry (2); show more...; Rudan, Igor (2); van Duijn, Cornelia ... (2); Thorsteinsdottir, Un ... (2); Stefansson, Kari (2); Verweij, Niek (2); Peters, Annette (2); Strauch, Konstantin (2); Samani, Nilesh J. (2); Farrall, Martin (2); Munroe, Patricia B. (2); Padmanabhan, Sandosh (2); Hicks, Andrew A. (2); Pramstaller, Peter P ... (2); Kooperberg, Charles (2); Harris, Tamara B (2); Liu, Yongmei (2); Loos, Ruth J F (2); Uitterlinden, André ... (2); Hayward, Caroline (2); Gudnason, Vilmundur (2); Franco, Oscar H. (2); de Bakker, Paul I. W ... (2); Kleber, Marcus E. (2); van Setten, Jessica (2); Boerwinkle, Eric (2); van der Harst, Pim (2); Watkins, Hugh (2); Isaacs, Aaron (2); Schlessinger, David (2); Goel, Anuj (2); Tanaka, Toshiko (2); Bandinelli, Stefania (2); Ferrucci, Luigi (2); McLachlan, Stela (2); Nolte, Ilja M. (2); Teumer, Alexander (2); Franke, Lude (2); Snieder, Harold (2); Jukema, J. Wouter (2); Trompet, Stella (2); Westra, Harm-Jan (2); Delgado, Graciela (2); Felix, Stephan B (2); Ehret, Georg B. (2); show less...

University: Uppsala University (2); Lund University (2); University of Gothenburg (1); Umeå University (1); Karolinska Institutet (1); Högskolan Dalarna (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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