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Sökning: WFRF:(Dove A)

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  • Knapek, C. A., et al. (författare)
  • COMPACT-a new complex plasma facility for the ISS
  • 2022
  • Ingår i: Plasma Physics and Controlled Fusion. - : Institute of Physics (IOP). - 0741-3335 .- 1361-6587. ; 64:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Complex plasma is a state of soft matter where micrometer-sized particles are immersed in a weakly ionized gas. The particles acquire negative charges of the order of several thousand elementary charges in the plasma, and they can form gaseous, liquid and crystalline states. Direct optical observation of individual particles allows to study their dynamics on the kinetic level even in large many-particle systems. Gravity is the dominant force in ground-based experiments, restricting the research to vertically compressed, inhomogeneous clouds, or two-dimensional systems, and masking dynamical processes mediated by weaker forces. An environment with reduced gravity, such as provided on the International Space Station (ISS), is therefore essential to overcome this limitations. We will present the research goals for the next generation complex plasma facility COMPACT to be operated onboard the ISS. COMPACT is envisaged as an international multi-purpose and multi-user facility that gives access to the full three-dimensional kinetic properties of the particles.
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  • Dove, Abigail, et al. (författare)
  • Cardiometabolic disease, cognitive decline, and brain structure in middle and older age
  • 2024
  • Ingår i: Alzheimer's and Dementia. - 2352-8729. ; 16:2
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: The presence of multiple cardiometabolic diseases (CMDs) has been linked to increased dementia risk, but the combined influence of CMDs on cognition and brain structure across the life course is unclear.METHODS: In the UK Biobank, 46,562 dementia-free participants completed a cognitive test battery at baseline and a follow-up visit 9 years later, at which point 39,306 also underwent brain magnetic resonance imaging. CMDs (diabetes, heart disease, and stroke) were ascertained from medical records. Data were analyzed using age-stratified (middle age [< 60] versus older [≥ 60]) mixed-effects models and linear regression.RESULTS: A higher number of CMDs was associated with significantly steeper global cognitive decline in older (β = –0.008; 95% confidence interval: −0.012, −0.005) but not middle age. Additionally, the presence of multiple CMDs was related to smaller total brain volume, gray matter volume, white matter volume, and hippocampal volume and larger white matter hyperintensity volume, even in middle age.DISCUSSION: CMDs are associated with cognitive decline in older age and poorer brain structural health beginning already in middle age.
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