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Sökning: WFRF:(Drucker David)

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1.
  • Björck, Amelie, et al. (författare)
  • Swedish Concrete Poetry in Focus
  • 1996
  • Ingår i: Experimental-Visual-Concrete. Avant-Garde Poetry since the 1960s. - : Rodopi. - 9051839596 ; , s. 317-335
  • Bokkapitel (refereegranskat)
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4.
  • Mathieson, Iain, et al. (författare)
  • The genomic history of southeastern Europe
  • 2018
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 555, s. 197-203
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Farming was first introduced to Europe in the mid-seventh millennium bc, and was associated with migrants from Anatolia who settled in the southeast before spreading throughout Europe. Here, to understand the dynamics of this process, we analysed genome-wide ancient DNA data from 225 individuals who lived in southeastern Europe and surrounding regions between 12000 and 500 bc. We document a west-east cline of ancestry in indigenous hunter-gatherers and, in eastern Europe, the early stages in the formation of Bronze Age steppe ancestry. We show that the first farmers of northern and western Europe dispersed through southeastern Europe with limited hunter-gatherer admixture, but that some early groups in the southeast mixed extensively with hunter-gatherers without the sex-biased admixture that prevailed later in the north and west. We also show that southeastern Europe continued to be a nexus between east and west after the arrival of farmers, with intermittent genetic contact with steppe populations occurring up to 2,000 years earlier than the migrations from the steppe that ultimately replaced much of the population of northern Europe.
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5.
  • Szczygieł, Julia Alicja, et al. (författare)
  • Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy : Preclinical Data in Rats
  • 2020
  • Ingår i: Frontiers in Molecular Neuroscience. - : Frontiers Media S. A.. - 1662-5099. ; 13
  • Tidskriftsartikel (refereegranskat)abstract
    • Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind, the present study aimed to provide important preclinical data on the effects of CG01 on the duration of transgene expression, cellular tropism, and potential side effects on body weight and cognitive function. The CG01 vector was administered unilaterally into the dorsal and ventral hippocampus of adult male rats and expression of both transgenes was found to remain elevated without a sign of decline at 6 months post-injection. CG01 appeared to mediate expression selectively in hippocampal neurons, without expression in astrocytes or oligodendrocytes. No effects were seen on body weight as well as on short- or long-term memory as revealed by testing in the Y-maze or Morris water maze tests. Thus these data show that unilateral CG01 vector treatment as future gene therapy in pharmacoresistant temporal lobe epilepsy patients should result in stable and long-term expression predominantly in neurons and be well tolerated without side effects on body weight and cognitive function.
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  • Resultat 1-5 av 5

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