SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Dyson K.) ;hsvcat:1"

Sökning: WFRF:(Dyson K.) > Naturvetenskap

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Santangelo, James S., et al. (författare)
  • Global urban environmental change drives adaptation in white clover
  • 2022
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375
  • Tidskriftsartikel (refereegranskat)abstract
    • Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural dines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale.
  •  
2.
  • Pershad, K., et al. (författare)
  • Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display
  • 2010
  • Ingår i: Protein Engineering Design & Selection. - : Oxford University Press (OUP). - 1741-0126 .- 1741-0134. ; 23:4, s. 279-288
  • Tidskriftsartikel (refereegranskat)abstract
    • To demonstrate the utility of phage display in generating highly specific antibodies, affinity selections were conducted on 20 related Src Homology 2 (SH2) domains (ABL1, ABL2, BTK, BCAR3, CRK, FYN, GRB2, GRAP2, LYN, LCK, NCK1, PTPN11 C, PIK3R1 C, PLC gamma 1 C, RASA1 C, SHC1, SH2D1A, SYK N, VAV1 and the tandem domains of ZAP70). The domains were expressed in Escherichia coli, purified and used in affinity selection experiments. In total, 1292/3800 of the resultant antibodies were shown to bind the target antigen. Of the 695 further evaluated in specificity ELISAs against all 20 SH2 domains, 379 antibodies were identified with unique specificity (i.e. monospecific). Sequence analysis revealed that there were at least 150 different clones with 1-19 different antibodies/antigen. This includes antibodies that distinguish between ABL1 and ABL2, despite their 89% sequence identity. Specificity was confirmed for many on protein arrays fabricated with 432 different proteins. Thus, even though the SH2 domains share a common three-dimensional structure and 20-89% identity at the primary structure level, we were able to isolate antibodies with exquisite specificity within this family of structurally related domains.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Tack, Ayco J. M. (1)
Nilsson, Peter (1)
Andrew, Nigel R. (1)
Alberti, Marina (1)
Pinho, Pedro (1)
Puentes, Adriana (1)
visa fler...
Laine, Anna Liisa (1)
Bonte, Dries (1)
del Val, Ek (1)
Branquinho, Cristina (1)
Peres-Neto, Pedro R. (1)
Granath, Gustaf (1)
Crawford, Andrew J. (1)
Zhao, Zhigang (1)
Classen, Aimée T. (1)
Sanders, Nathan J. (1)
Ellers, Jacintha (1)
Raeymaekers, Joost A ... (1)
Brans, Kristien, I (1)
Gagnon, Edeline (1)
Scheepens, J.F. (1)
Parachnowitsch, Amy ... (1)
Gräslund, S (1)
Santangelo, James S. (1)
Ness, Rob W. (1)
Angeoletto, Fabio (1)
Anstett, Daniel N. (1)
Anstett, Julia (1)
Baena-Diaz, Fernanda (1)
Carlen, Elizabeth J. (1)
Chaves, Jaime A. (1)
Comerford, Mattheau ... (1)
Dyson, Karen (1)
Falahati-Anbaran, Mo ... (1)
Fellowes, Mark D. E. (1)
Hodgins, Kathryn A. (1)
Iñiguez-Armijos, Car ... (1)
Lázaro-Lobo, Adrián (1)
Moles, Angela T. (1)
Munshi-South, Jason (1)
Paule, Juraj (1)
Porth, Ilga M. (1)
Santiago-Rosario, Lu ... (1)
Whitney, Kaitlin Sta ... (1)
Johnson, Marc T. J. (1)
Rivas-Torres, Gonzal ... (1)
Anderson, Jill T. (1)
Colwill, K (1)
Dominoni, Davide M. (1)
Szulkin, Marta (1)
visa färre...
Lärosäte
Kungliga Tekniska Högskolan (1)
Uppsala universitet (1)
Stockholms universitet (1)
Lunds universitet (1)
Karolinska Institutet (1)
Sveriges Lantbruksuniversitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (2)Ta bort avgränsningen

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy