| 1. |
- Brownstein, Catherine A., et al.
(author)
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An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge
- 2014
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In: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 15:3, s. R53-
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Journal article (peer-reviewed)abstract
- Background: There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing genetic disease starting from clinical case history and genome sequencing data. DNA samples were obtained from three families with heritable genetic disorders and genomic sequence data were donated by sequencing platform vendors. The challenge was to analyze and interpret these data with the goals of identifying disease-causing variants and reporting the findings in a clinically useful format. Participating contestant groups were solicited broadly, and an independent panel of judges evaluated their performance. Results: A total of 30 international groups were engaged. The entries reveal a general convergence of practices on most elements of the analysis and interpretation process. However, even given this commonality of approach, only two groups identified the consensus candidate variants in all disease cases, demonstrating a need for consistent fine-tuning of the generally accepted methods. There was greater diversity of the final clinical report content and in the patient consenting process, demonstrating that these areas require additional exploration and standardization. Conclusions: The CLARITY Challenge provides a comprehensive assessment of current practices for using genome sequencing to diagnose and report genetic diseases. There is remarkable convergence in bioinformatic techniques, but medical interpretation and reporting are areas that require further development by many groups.
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| 2. |
- Fields, Sherecce, et al.
(author)
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Examining the Psychometric Properties of the Barratt Impulsiveness Scale Brief Form in Justice-Involved Samples
- 2015
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In: Psychological Assessment. - : American Psychological Association (APA). - 1040-3590 .- 1939-134X. ; 27:4, s. 1211-1218
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Journal article (peer-reviewed)abstract
- Impulsivity is an important component If many forms of psychopathology. Though widely used as an index of this construct, the 30-item Barratt Impulsiveness Scale-11 (HIS-11) has demonstrated questionable psychometric properties in several research reports. An 8-item shortened Version has recently been proposed, the Barran Impulsiveness Scale Brief (BIS-Brief) form, which was designed to overcome some of the limitations of the longer scale. In this report, we examine the internal structure and theoretically relevant external correlates of this new short form in large archival samples of individuals involved in the criminal justice system (prison inmates, substance abusers in mandatory treatment, and forensic inpatients). Confirmatory factor analysis of the BIS-Brief indicates adequate fit following a relatively minor modification. Correlations between the HIS-Brief and an array' of criterion measures other self-report scales, interview-based measures, and behavioral outcomes are consistent with predictions and show relatively little or no decrement in predictive validity when compared with the 30-item HIS-11. Our results suggest that the HIS-Brief is a promising brief measure of impulsivity that evinces good psychometric properties across a range of offender samples.
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| 3. |
- Kelley, Shannon E., et al.
(author)
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A dimensional comparison of a self-report and a structured interview measure of conduct disorder
- 2016
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In: Journal of Personality Disorders. - 0885-579X .- 1943-2763. ; 30:2, s. 232-241
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Journal article (peer-reviewed)abstract
- Eligibility for a diagnosis of antisocial personality disorder (ASPD) requires evidence of antecedent conduct disorder (CD). Accurately identifying CD may be influenced by various factors, including assessment methodology. The present study used a two-parameter latent variable model to examine the relative performance of a self-report measure and a structured clinical interview in retrospectively detecting the CD spectrum among adult male offenders (N = 1,159). Self-report and clinical interview tended to converge regarding the rank order of severity indicated by CD symptom criteria. In addition, at relatively low levels of CD severity, self-report provided more information about the CD spectrum than did clinical interview. At relatively higher levels of CD severity, however, clinical interview provided more information about the CD spectrum than did self-report. Latent variable models offer a potential means of combining multiple assessment methods in a way that maximizes information gleaned by capitalizing on the contextual strengths of each approach.
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