SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Eiriksdottir Gudny) ;pers:(Stancáková Alena)"

Sökning: WFRF:(Eiriksdottir Gudny) > Stancáková Alena

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Kilpeläinen, Tuomas O, et al. (författare)
  • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
  • 2011
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:8, s. 753-60
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
  •  
2.
  • Wessel, Jennifer, et al. (författare)
  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
  • 2015
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF = 1.4%) with lower FG (beta = -0.09 +/- 0.01 mmol l(-1), P = 3.4 x 10(-12)), T2D risk (OR[95% CI] = 0.86[0.76-0.96], P = 0.010), early insulin secretion (beta = -0.07 +/- 0.035 pmol(insulin) mmol(glucose)(-1), P = 0.048), but higher 2-h glucose (beta = 0.16 +/- 0.05 mmol l(-1), P = 4.3 x 10(-4)). We identify a gene-based association with FG at G6PC2 (p(SKAT) = 6.8 x 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF = 20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (beta = 0.02 +/- 0.004 mmol l(-1), P = 1.3 x 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
  •  
3.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (3)
Författare/redaktör
Soranzo, Nicole (3)
Rudan, Igor (3)
Wareham, Nicholas J. (3)
Stancáková, Alen... (3)Ta bort avgränsningen
Kuusisto, Johanna (3)
Laakso, Markku (3)
visa fler...
Amin, Najaf (3)
van Duijn, Cornelia ... (3)
Ingelsson, Erik (3)
Oostra, Ben A. (3)
Barroso, Ines (3)
Walker, Mark (3)
Eiriksdottir, Gudny (3)
Harris, Tamara B (3)
Liu, Yongmei (3)
Loos, Ruth J F (3)
Hofman, Albert (3)
Uitterlinden, André ... (3)
Psaty, Bruce M (3)
Hayward, Caroline (3)
Khaw, Kay-Tee (2)
Vandenput, Liesbeth, ... (2)
Lorentzon, Mattias, ... (2)
Salomaa, Veikko (2)
Jula, Antti (2)
Perola, Markus (2)
Campbell, Harry (2)
Ohlsson, Claes, 1965 (2)
Kilpeläinen, Tuomas ... (2)
Langenberg, Claudia (2)
Boehnke, Michael (2)
Ripatti, Samuli (2)
Thorleifsson, Gudmar (2)
Thorsteinsdottir, Un ... (2)
Stefansson, Kari (2)
Rotter, Jerome I. (2)
Mellström, Dan, 1945 (2)
Gieger, Christian (2)
Wichmann, H. Erich (2)
Spector, Timothy D (2)
Luan, Jian'an (2)
Wilson, James F. (2)
Ljunggren, Östen (2)
Jansson, John-Olov, ... (2)
Zillikens, M. Carola (2)
Rivadeneira, Fernand ... (2)
Zhao, Jing Hua (2)
Garcia, Melissa (2)
Klopp, Norman (2)
Launer, Lenore J (2)
visa färre...
Lärosäte
Göteborgs universitet (2)
Uppsala universitet (2)
Lunds universitet (2)
Karolinska Institutet (2)
Umeå universitet (1)
Stockholms universitet (1)
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)
Naturvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy