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Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Scelo, Ghislaine (author)
Purdue, Mark P. (author)
Brown, Kevin M. (author)
show more...
Johansson, Mattias (author)
Wang, Zhaoming (author)
Eckel-Passow, Jeanette E. (author)
Ye, Yuanqing (author)
Hofmann, Jonathan N. (author)
Choi, Jiyeon (author)
Foll, Matthieu (author)
Gaborieau, Valerie (author)
Machiela, Mitchell J. (author)
Colli, Leandro M. (author)
Li, Peng (author)
Sampson, Joshua N. (author)
Abedi-Ardekani, Behnoush (author)
Besse, Celine (author)
Blanche, Helene (author)
Boland, Anne (author)
Burdette, Laurie (author)
Chabrier, Amelie (author)
Durand, Geoffroy (author)
Le Calvez-Kelm, Florence (author)
Prokhortchouk, Egor (author)
Robinot, Nivonirina (author)
Skryabin, Konstantin G. (author)
Wozniak, Magdalena B. (author)
Yeager, Meredith (author)
Basta-Jovanovic, Gordana (author)
Dzamic, Zoran (author)
Foretova, Lenka (author)
Holcatova, Ivana (author)
Janout, Vladimir (author)
Mates, Dana (author)
Mukeriya, Anush (author)
Rascu, Stefan (author)
Zaridze, David (author)
Bencko, Vladimir (author)
Cybulski, Cezary (author)
Fabianova, Eleonora (author)
Jinga, Viorel (author)
Lissowska, Jolanta (author)
Lubinski, Jan (author)
Navratilova, Marie (author)
Rudnai, Peter (author)
Szeszenia-Dabrowska, Neonila (author)
Benhamou, Simone (author)
Cancel-Tassin, Geraldine (author)
Cussenot, Olivier (author)
Baglietto, Laura (author)
Boeing, Heiner (author)
Khaw, Kay-Tee (author)
Weiderpass, Elisabete (author)
Ljungberg, Börje (author)
Sitaram, Raviprakash T. (author)
Bruinsma, Fiona (author)
Jordan, Susan J. (author)
Severi, Gianluca (author)
Winship, Ingrid (author)
Hveem, Kristian (author)
Vatten, Lars J. (author)
Fletcher, Tony (author)
Koppova, Kvetoslava (author)
Larsson, Susanna C. (author)
Wolk, Alicja (author)
Banks, Rosamonde E. (author)
Selby, Peter J. (author)
Easton, Douglas F. (author)
Pharoah, Paul (author)
Andreotti, Gabriella (author)
Freeman, Laura E. Beane (author)
Koutros, Stella (author)
Albanes, Demetrius (author)
Mannisto, Satu (author)
Weinstein, Stephanie (author)
Clark, Peter E. (author)
Edwards, Todd L. (author)
Lipworth, Loren (author)
Gapstur, Susan M. (author)
Stevens, Victoria L. (author)
Carol, Hallie (author)
Freedman, Matthew L. (author)
Pomerantz, Mark M. (author)
Cho, Eunyoung (author)
Kraft, Peter (author)
Preston, Mark A. (author)
Wilson, Kathryn M. (author)
Gaziano, J. Michael (author)
Sesso, Howard D. (author)
Black, Amanda (author)
Freedman, Neal D. (author)
Huang, Wen-Yi (author)
Anema, John G. (author)
Kahnoski, Richard J. (author)
Lane, Brian R. (author)
Noyes, Sabrina L. (author)
Petillo, David (author)
Teh, Bin Tean (author)
Peters, Ulrike (author)
White, Emily (author)
Anderson, Garnet L. (author)
Johnson, Lisa (author)
Luo, Juhua (author)
Buring, Julie (author)
Lee, I-Min (author)
Chow, Wong-Ho (author)
Moore, Lee E. (author)
Wood, Christopher (author)
Eisen, Timothy (author)
Henrion, Marc (author)
Larkin, James (author)
Barman, Poulami (author)
Leibovich, Bradley C. (author)
Choueiri, Toni K. (author)
Lathrop, G. Mark (author)
Rothman, Nathaniel (author)
Deleuze, Jean-Francois (author)
Mckay, James D. (author)
Parker, Alexander S. (author)
Wu, Xifeng (author)
Houlston, Richard S. (author)
Brennan, Paul (author)
Chanock, Stephen J. (author)
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 (publisher)
NATURE PUBLISHING GROUP 2017
2017
English.
In: Nature Communications. - 2041-1723. ; 8
  • swepub:Mat__t
Abstract Subject headings
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  • Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1 x 10(-10)), 3p22.1 (rs67311347, P = 2.5 x 10(-8)), 3q26.2 (rs10936602, P = 8.8 x 10(-9)), 8p21.3 (rs2241261, P = 5.8 x 10(-9)), 10q24.33-q25.1 (rs11813268, P = 3.9 x 10(-8)), 11q22.3 (rs74911261, P = 2.1 x 10(-10)) and 14q24.2 (rs4903064, P = 2.2 x 10(-24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

Subject headings

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Urology and Nephrology  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Urologi och njurmedicin  (hsv)

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By the author/editor
Scelo, Ghislaine
Purdue, Mark P.
Brown, Kevin M.
Johansson, Matti ...
Wang, Zhaoming
Eckel-Passow, Je ...
show more...
Ye, Yuanqing
Hofmann, Jonatha ...
Choi, Jiyeon
Foll, Matthieu
Gaborieau, Valer ...
Machiela, Mitche ...
Colli, Leandro M ...
Li, Peng
Sampson, Joshua ...
Abedi-Ardekani, ...
Besse, Celine
Blanche, Helene
Boland, Anne
Burdette, Laurie
Chabrier, Amelie
Durand, Geoffroy
Le Calvez-Kelm, ...
Prokhortchouk, E ...
Robinot, Nivonir ...
Skryabin, Konsta ...
Wozniak, Magdale ...
Yeager, Meredith
Basta-Jovanovic, ...
Dzamic, Zoran
Foretova, Lenka
Holcatova, Ivana
Janout, Vladimir
Mates, Dana
Mukeriya, Anush
Rascu, Stefan
Zaridze, David
Bencko, Vladimir
Cybulski, Cezary
Fabianova, Eleon ...
Jinga, Viorel
Lissowska, Jolan ...
Lubinski, Jan
Navratilova, Mar ...
Rudnai, Peter
Szeszenia-Dabrow ...
Benhamou, Simone
Cancel-Tassin, G ...
Cussenot, Olivie ...
Baglietto, Laura
Boeing, Heiner
Khaw, Kay-Tee
Weiderpass, Elis ...
Ljungberg, Börje
Sitaram, Ravipra ...
Bruinsma, Fiona
Jordan, Susan J.
Severi, Gianluca
Winship, Ingrid
Hveem, Kristian
Vatten, Lars J.
Fletcher, Tony
Koppova, Kvetosl ...
Larsson, Susanna ...
Wolk, Alicja
Banks, Rosamonde ...
Selby, Peter J.
Easton, Douglas ...
Pharoah, Paul
Andreotti, Gabri ...
Freeman, Laura E ...
Koutros, Stella
Albanes, Demetri ...
Mannisto, Satu
Weinstein, Steph ...
Clark, Peter E.
Edwards, Todd L.
Lipworth, Loren
Gapstur, Susan M ...
Stevens, Victori ...
Carol, Hallie
Freedman, Matthe ...
Pomerantz, Mark ...
Cho, Eunyoung
Kraft, Peter
Preston, Mark A.
Wilson, Kathryn ...
Gaziano, J. Mich ...
Sesso, Howard D.
Black, Amanda
Freedman, Neal D ...
Huang, Wen-Yi
Anema, John G.
Kahnoski, Richar ...
Lane, Brian R.
Noyes, Sabrina L ...
Petillo, David
Teh, Bin Tean
Peters, Ulrike
White, Emily
Anderson, Garnet ...
Johnson, Lisa
Luo, Juhua
Buring, Julie
Lee, I-Min
Chow, Wong-Ho
Moore, Lee E.
Wood, Christophe ...
Eisen, Timothy
Henrion, Marc
Larkin, James
Barman, Poulami
Leibovich, Bradl ...
Choueiri, Toni K ...
Lathrop, G. Mark
Rothman, Nathani ...
Deleuze, Jean-Fr ...
Mckay, James D.
Parker, Alexande ...
Wu, Xifeng
Houlston, Richar ...
Brennan, Paul
Chanock, Stephen ...
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