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Sökning: WFRF:(Ekestubbe S)

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  • Schaufelberger, Maria, 1954-, et al. (författare)
  • Validity of heart failure diagnoses made in 2000-2012 in western Sweden.
  • 2020
  • Ingår i: ESC heart failure. - 2055-5822. ; 7:1, s. 37-46
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study is to validate a diagnosis of heart failure (HF) according to the European Society of Cardiology (ESC) guidelines among patients hospitalized at Sahlgrenska University Hospital, Gothenburg, Sweden, between 2000 and 2012.In Sweden, it is mandatory to report all hospital discharge diagnoses to the Swedish national inpatient register. In total, 27 517 patients were diagnosed with HF at the Sahlgrenska University hospital between 2000 and 2012. Altogether, 1100 records with a primary (n = 550) or contributory (n = 550) diagnosis of HF were randomly selected. The diagnosis was validated according to the ESC guidelines from 1995, 2001, 2005, and 2008, and cases were divided into three groups: definite, probable, and miscoded. In total, 965 cases were validated, while 135 records were excluded for various reasons. Of the 965 records, the diagnosis was validated as definite in 601 (62.3%) and as probable in 310 (32.1%); only 54 (5.6%) of cases had been miscoded. Echocardiography, as an objective evidence of cardiac dysfunction, had been performed in 581 (96.7%) of the definite, 106 (34.2%) of the probable, and 31 (57.4%) of the miscoded cases. Among the probable cases, the main reason they had not been classified as a definitive diagnosis of HF was lack of examination by echocardiography (63.8%).The overall validity of HF diagnosis at Sahlgrenska University Hospital is high. This may reflect a high diagnostic validity at the time of diagnosis in the national Swedish patient register, supporting the continued use of this register in epidemiological research.
  • Ekestubbe, Annika, 1953-, et al. (författare)
  • Low-dose tomographic techniques for dental implant planning.
  • 1996
  • Ingår i: The International journal of oral & maxillofacial implants. - 0882-2786. ; 11:5, s. 650-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Image quality in preimplant computerized tomography (CT) examinations made with different radiation doses (40 to 280 mAs) and scanning modes (standard and helical axial, 15-degree angled, and frontal) and in conventional spiral tomography (Scanora) was compared. Mandibular canal and alveolar bone crest visibility was evaluated in images from mandibular jaw segments. Visibility was unaffected by radiation dose in CT examinations except in frontal scanning, where a small actual difference was statistically significant. Differences among CT scanning modes and between CT and conventional spiral tomography were highly significant. Low-dose mandibular preimplant tomography can be performed with CT using lower-than-normal radiation doses or with conventional spiral tomography.
  • Ekestubbe, Sofie, 1982-, et al. (författare)
  • The amino-terminal part of the needle-tip translocator LcrV of Yersinia pseudotuberculosis is required for early targeting of YopH and in vivo virulence
  • 2016
  • Ingår i: Frontiers in Cellular and Infection Microbiology. - 2235-2988. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Type III secretion systems (T3SS) are dedicated to targeting anti-host effector proteins into the cytosol of the host cell to promote bacterial infection. Delivery of the effectors requires three specific translocator proteins, of which the hydrophilic translocator, LcrV, is located at the tip of the T3SS needle and is believed to facilitate insertion of the two hydrophobic translocators into the host cell membrane. Here we used Yersinia as a model to study the role of LcrV in T3SS mediated intracellular effector targeting. Intriguingly, we identified N-terminal IcrV mutants that, similar to the wild-type protein, efficiently promoted expression, secretion and intracellular levels of Yop effectors, yet they were impaired in their ability to inhibit phagocytosis by J774 cells. In line with this, the YopH mediated dephosphorylation of Focal Adhesion Kinase early after infection was compromised when compared to the wild type strain. This suggests that the mutants are unable to promote efficient delivery of effectors to their molecular targets inside the host cell upon host cell contact. The significance of this was borne out by the fact that the mutants were highly attenuated for virulence in the systemic mouse infection model. Our study provides both novel and significant findings that establish a role for LcrV in early targeting of effectors in the host cell.</p>
  • Lofthag-Hansen, S, et al. (författare)
  • Calculating effective dose on a cone beam computed tomographydevice: 3D Accuitomo and 3D Accuitomo FPD
  • 2008
  • Ingår i: Dento-Maxillo-Facial Radiology. - 0250-832X .- 1476-542X. ; 37:2, s. 72-79
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Objectives</strong>: This study evaluates two methods for calculating effective dose, CT dose index (CTDI) and dose–area product (DAP) for a cone beam CT (CBCT) device: 3D Accuitomo at field size 30x40 mm and 3D Accuitomo FPD at field sizes 40x40 mm and 60x60 mm. Furthermore, the effective dose of three commonly used examinations in dental radiology was determined.</p> <p><strong>Methods</strong>: CTDI<sub>100</sub> measurements were performed in a CT head dose phantom with a pencil ionization chamber connected to an electrometer. The rotation centre was placed in the centre of the phantom and also, to simulate a patient examination, in the upper left cuspid region. The DAP value was determined with a plane-parallel transmission ionization chamber connected to an electrometer. A conversion factor of 0.08 mSv per Gy cm<sup>2</sup> was used to determine the effective dose from DAP values. Based on data from 90 patient examinations, DAP and effective dose were determined.</p> <p><strong>Results: </strong>CTDI<sub>100</sub> measurements showed an asymmetric dose distribution in the phantom when simulating a patient examination. Hence a correct value of CTDIw could not be calculated. The DAP value increased with higher tube current and tube voltage values. The DAP value was also proportional to the field size. The effective dose was found to be 11–77 microSv for the specific examinations.</p> <p><strong>Conclusions</strong>: DAP measurement was found to be the best method for determining effective dose for the Accuitomo. Determination of specific conversion factors in dental radiology must, however, be further developed</p>
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