| 1. |
- Bousquet, J, et al.
(författare)
-
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
-
Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
-
Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Eklund, P., et al.
(författare)
-
Similarities between powersets of terms
- 2004
-
Ingår i: Fuzzy sets and systems (Print). - : Elsevier. - 0165-0114 .- 1872-6801. ; 144:1, s. 213-225
-
Tidskriftsartikel (refereegranskat)abstract
- Generalisation of the foundational basis for many-valued logic programming builds upon generalised terms in the form of powersets of terms. A categorical approach involving set and term functors as monads allows for a study of monad compositions that provide variable substitutions and compositions thereof. In this paper, substitutions and unifiers appear as constructs in Kleisli categories related to particular composed powerset term monads. Specifically, we show that a frequently used similarity-based approach to fuzzy unification is compatible with the categorical approach, and can be adequately extended in this setting; also some examples are included in order to illuminate the definitions.
|
|
| 9. |
- Rodhe, A., Seibert, J., Seibert, P. & Eklund, A.
(författare)
-
Groundwater Dynamics in a Till Hillslope: Flow Directions, Gradients and Delay
- 2001
-
Ingår i: Poster presented at AGU Chapman Conference State-of-the-Art of Hillslope Hydrology, Sunriver, Oregon, October 8-12, 2001.
-
Konferensbidrag (refereegranskat)
|
|
| 10. |
- Doliška, A., et al.
(författare)
-
Antithrombotic properties of sulfated wood-derived galactoglucomannans
- 2012
-
Ingår i: Holzforschung. - 0018-3830 .- 1437-434X. ; 66:2, s. 149-154
-
Tidskriftsartikel (refereegranskat)abstract
- Galactoglucomannans (GGMs) are water-soluble polysaccharides released and accumulated in process waters in the production of thermomechanical pulp. The general trend in the forestry industry is moving towards bio-refineries, for example utilizing these hemicelluloses as bioactive substances. At present, there is no industrial use of wood-derived mannans. In this study, GGMs extracted from thermomechanical pulp, as well as further carboxymethyl-ated galactoglucomannans (CM-GGMs), were sulfated to increase their antithrombotic properties. The products were characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance and capillary electrophoresis. The carbohydrate composition and sulfur amounts were determined. The products' total charges were determined by polyelectrolyte titrations and their antithrombotic effect was measured based on the activated partial thromboplastin time. The results showed a significant increase in the antithrombotic effect of the sulfated galactoglucomannans from spruce wood and thus a potential new use for wood-derived mannans.
|
|
