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- Thompson, Paul M., et al.
(författare)
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The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
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Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
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Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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| 3. |
- Ekman, Marianne, et al.
(författare)
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Incremental innovations in organizational performance in health care
- 2010
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Ingår i: Learning Regional Innovation. - London : Palgrave Macmillan. - 9780230304154 ; , s. 104-119
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In this chapter we present a case of how the concept of patient-centred care moved from a concept generally defined in national policy documents to a concept as a point of orientation, and how it became a conceptual innovation in practice. The emphasis was on integrated forms of organization such as team work, networking and development coalition. Local-regional knowledge resources emerged as critically significant because this is knowledge linked to practice, which could, therefore, operate ‘on line’ and do things from inside the process rather than from afar. The case is built on the idea that the learning necessary to provide the concept with a specific content emerges only through launching efforts to make the concept real in specific situations. It demonstrates that these efforts do not take the form of simple ‘application’. Rather, they demand rethinking about what is already known, a process that leads to renewed understanding of the concept. The concept of patient-centred care was used to enable broad-based involvement, mobilization and learning as the basis for innovation.
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| 4. |
- Rådsten-Ekman, Maria, et al.
(författare)
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Case-study evaluation of a low and vegetated noise barrier in an urban public space
- 2011
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Ingår i: Proceedings of Inter-Noise 2011. - Osaka, Japan: : The Institute of Noise Control Engineering of Japan and the Acoustical Society of Japan.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- To improve the sound environment along a popular esplanade in Lyon, France, a 1 m high vegetated noise barrier was erected to protect against noise from an adjacent road. The barrier was made of a metallic structure, filled with a substrate on which 40 plants per square meter were grown on both sides. The effect of the barrier was evaluated by acoustic measurements conducted before and after the barrier was erected, as well as, by a questionnaire study in which pedestrians were asked to assess the sound environment both behind and at the side of the barrier. The barrier reduced the sound pressure level from about 67 to 62 dB (LAeq), at sitting height (1.2 m), 3.5 m from the roadside. Questionnaires responses (n = 349) from the same location showed that the barrier reduced road-traffic noise annoyance, and increased the overall quality of the sound environment by making it slightly calmer and slightly more pleasant. However, these effects were fairly small and the sound environment was still perceived as annoying by most of the respondents. Overall, the result thus suggested that the barrier made the sound environment better but not good. Further work will include detailed psychoacoustic analysis of the questionnaire data, as well as listening experiments using binaural recordings from the site.
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