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- Backlund, L, et al.
(författare)
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Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder
- 2015
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Ingår i: Molecular neuropsychiatry. - : S. Karger AG. - 2296-9209. ; 1:2, s. 76-81
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about the relationship between treatments for bipolar disorder (BD), their therapeutic responses and the DNA methylation status. We investigated whether global DNA methylation levels differ between healthy controls and bipolar patients under different treatments. Global DNA methylation was measured in leukocyte DNA from bipolar patients under lithium monotherapy (n = 29) or combination therapy (n = 32) and from healthy controls (n = 26). Lithium response was assessed using the Alda scale. Lithium in monotherapy was associated with hypomethylation (F = 4.63, p = 0.036). Lithium + valproate showed a hypermethylated pattern compared to lithium alone (F = 7.27, p = 0.011). Lithium response was not associated with DNA methylation levels. These data suggest that the choice of treatment in BD may lead to different levels of global DNA methylation. However, further research is needed to understand its clinical significance.
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| 3. |
- Kato, S, et al.
(författare)
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DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients
- 2012
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Ingår i: Nephron extra. - : S. Karger AG. - 1664-5529. ; 2:1, s. 159-68
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background/Aims:</i></b> Inflammation is an established mortality risk factor in chronic kidney disease (CKD) patients. Although a previous report showed that uremic Caucasian patients with inflammation had signs of global DNA hypermethylation, it is still unknown whether DNA hypermethylation is linked to inflammatory markers including a marker of bacterial infections in Japanese CKD patients. <b><i>Methods:</i></b> In 44 consecutive incident dialysis patients (26 males, mean age 59 ± 12 years) without clinical signs of infection, global DNA methylation was evaluated in peripheral blood DNA using the <i>Hpa</i>II<i>/Msp</i>I ratio by the luminometric methylation assay method. A lower ratio of <i>Hpa</i>II<i>/Msp</i>I indicates global DNA hypermethylation. Procalcitonin (PCT), a marker of inflammation due to bacterial infections, was measured using an immunochromatographic assay. <b><i>Results:</i></b> The patients were divided into hyper- and hypomethylation groups based on the median value of the <i>Hpa</i>II<i>/Msp</i>I ratio 0.31 (range 0.29–0.37). Whereas patients in the hypermethylation group had higher ferritin levels [133.0 (51.5–247.3) vs. 59.5 (40.0–119.0) ng/ml; p = 0.046], there were no significant differences in age, gender, diabetes, smoking, anemia or serum albumin levels. However, the <i>Hpa</i>II<i>/Msp</i>I ratio showed significant negative correlations with PCT (ρ = –0.32, p = 0.035) and ferritin (ρ = –0.33, p = 0.027) in Spearman’s rank test. In a multiple linear regression analysis, PCT and ferritin were associated with a lower <i>Hpa</i>II<i>/Msp</i>I ratio (R<sup>2</sup> = 0.24, p = 0.013). <b><i>Conclusion:</i></b> In this study, global DNA hypermethylation was associated with ferritin and, most likely, PCT, suggesting that inflammation induced by subclinical bacterial infection promoted DNA methylation.
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