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The complement regu...
The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity
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Basmarke-Wehelie, Rahma (författare)
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Sjölinder, Hong (författare)
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Jurkowski, Wiktor (författare)
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visa fler...
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Elofsson, Arne (författare)
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Arnqvist, Anna (författare)
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Engstrand, Lars (författare)
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Hagner, Matthias (författare)
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Wallin, Elin (författare)
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Guan, Na (författare)
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Kuranasekera, Hasanthi (författare)
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Aro, Helena (författare)
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Jonsson, Ann-Beth (författare)
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visa färre...
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(utgivare)
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(utgivare)
- 2011
- 2011
- Engelska.
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Ingår i: Gastroenterology. - 0016-5085. ; 141:3, 918-928
Abstract
Ämnesord
Stäng
- BACKGROUND & AIMS: CD46 is a C3b/C4b binding complement regulator and a receptor for several human pathogens. We examined the interaction between CD46 and Helicobacter pylori (a bacterium that colonizes the human gastric mucosa and causes gastritis), peptic ulcers, and cancer. METHODS: Using gastric epithelial cells, we analyzed a set of H pylori strains and mutants for their ability to interact with CD46 and/or influence CD46 expression. Bacterial interaction with full-length CD46 and small CD46 peptides was evaluated by flow cytometry, fluorescence microscopy, enzyme-linked immunosorbent assay, and bacterial survival analyses. RESULTS: H pylori infection caused shedding of CD46 into the extracellular environment. A soluble form of CD46 bound to H pylori and inhibited growth, in a dose- and time-dependent manner, by interacting with urease and alkyl hydroperoxide reductase, which are essential bacterial pathogenicity-associated factors. Binding of CD46 or CD46-derived synthetic peptides blocked the urease activity and ability of bacteria to survive in acidic environments. Oral administration of one CD46 peptide eradicated H pylori from infected mice. CONCLUSIONS: CD46 is an antimicrobial agent that can eradicate H pylori. CD46 peptides might be developed to treat H pylori infection.
Ämnesord
- Natural Sciences (hsv)
- Biological Sciences (hsv)
- Microbiology (hsv)
- Naturvetenskap (hsv)
- Biologiska vetenskaper (hsv)
- Mikrobiologi (hsv)
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Gastroenterology and Hepatology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Gastroenterologi (hsv)
- mikrobiologi (su)
- Microbiology (su)
Nyckelord
- AhpC
- Stomach Cancer
- Bacterial Infection
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Basmarke-Wehelie ...
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Sjölinder, Hong
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Jurkowski, Wikto ...
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Elofsson, Arne
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Arnqvist, Anna
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Engstrand, Lars
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visa fler...
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Hagner, Matthias
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Wallin, Elin
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Guan, Na
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Kuranasekera, Ha ...
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Aro, Helena
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Jonsson, Ann-Bet ...
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