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- Ström, Kristoffer, et al.
(författare)
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Genetic variation at RAB3GAP2 and its role in exercise-related adaptation and recovery
- 2021
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Skeletal muscle fiber composition and capillary density influence physical performance and whole-body metabolic properties. ~45% of the variance in fiber type is heritable, which motivated us to perform a genome-wide association study of skeletal muscle histology from 656 Swedish men. Four independent variants were associated (p
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- Winsnes, Casper F., et al.
(författare)
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A proteome map of the micronucleus reveals a diversity of nuclear functions
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Micronuclei are small nuclei-like structures, commonly associated with cancer, that have long been used as biomarkers of DNA damage and chromosomal instability. They are caused by lagging chromosomes or chromosome fragments that fail to be incorporated into primary nuclei during mitosis. Until recently, they were thought to be inert but recent studies have shown that micronuclei may be playing an active role in cellular biology, particularly in the context of cancer and chromothripsis. However, the precise ways that micronuclei perform these functions remain unknown.In this study, we perform the first comprehensive mapping and functional analysis of the micronuclear proteome. We demonstrate that micronuclei are involved in several known cellular processes, showing high enrichment for proteins involved in gene expression, cell cycle checkpoints, and DNA damage repair among other things. Furthermore, we show that several poorly categorized proteins also localize to micronuclei, hinting towards unknown functionality beyond the already known. Our results indicate that micronuclei are more involved in cellular activity than previously thought and that .We anticipate this resource to be a starting point for further investigation into the functions of micronuclei, particularly for their role in DNA damage and the chromothripsis phenomenon. Additionally, we believe that it can be used for investigation into errors in mitosis and new ways of treating diseases.
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- Ålund, Murielle, et al.
(författare)
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Reproductive -omics of a wild avian speciation model unveils candidate genes for gamete interaction
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The complex nature of interspecific interactions contributing to reproductive isolation means that we still know little about their molecular basis. Male reproductive traits are notorious for their fast evolution at the phenotypic and genotypic level, and divergence in components of the ejaculate can lead to incompatibilities between closely related species. Making use of recent advances of molecular tools and the extensive knowledge on the biology and ecology of young sister species, here the pied (Ficedula hypoleuca) and collared flycatcher (F. albicollis), allows the identification of candidate phenotypes and the underlying genotypes maintaining species boundaries. Pied flycatcher females can avoid costly production of sterile hybrids when mated to collared flycatchers by cryptically favouring conspecific sperm. Here, we describe the testes transcriptome and sperm proteome of both species, confirm the complexity of avian sperm development and functions and identify several candidate genes for interactions between sperm and the female reproductive tract, using multiple independent measures of divergence between the species. We show that divergence at the transcriptional and translational levels can potentially lead to the evolution of reproductive incompatibilities despite low levels of sequence divergence, and suggest that integrating several -omics techniques with knowledge of the biology of naturally hybridizing species will greatly improve our understanding of the molecular basis of speciation in the near future.
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