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Structural changes ...
Structural changes induced by electroconvulsive therapy are associated with clinical outcome
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- Mulders, Peter C.R. (författare)
- Radboud University Nijmegen,Radboud University Medical Center
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- Llera, Alberto (författare)
- Radboud University Nijmegen
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- Beckmann, Christian F. (författare)
- University of Oxford,Radboud University Nijmegen
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- Vandenbulcke, Mathieu (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Stek, Max (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,GGZ inGeest Specialized Mental Health Care,Vrije Universiteit Amsterdam
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- Sienaert, Pascal (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Redlich, Ronny (författare)
- University of Münster
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- Petrides, Georgios (författare)
- Feinstein Institute for Medical Research,Hofstra University,The Zucker Hillside Hospital
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- Oudega, Mardien Leoniek (författare)
- Vrije Universiteit Amsterdam,GGZ inGeest Specialized Mental Health Care,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Oltedal, Leif (författare)
- University of Bergen,Haukeland University Hospital
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- Oedegaard, Ketil J. (författare)
- Haukeland University Hospital,University of Bergen
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- Narr, Katherine L. (författare)
- University of California, Los Angeles
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- Magnusson, Peter O. (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups
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- Kessler, Ute (författare)
- Haukeland University Hospital,University of Bergen
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- Jorgensen, Anders (författare)
- University of Copenhagen
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- Espinoza, Randall (författare)
- University of California, Los Angeles
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- Enneking, Verena (författare)
- University of Münster
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- Emsell, Louise (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Dols, Annemieke (författare)
- GGZ inGeest Specialized Mental Health Care,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Dannlowski, Udo (författare)
- University of Münster
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- Bolwig, Tom G. (författare)
- Copenhagen University Hospital
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- Bartsch, Hauke (författare)
- University of California, San Diego,Haukeland University Hospital
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- Argyelan, Miklos (författare)
- Feinstein Institute for Medical Research,Hofstra University,The Zucker Hillside Hospital
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- Anand, Amit (författare)
- Cleveland Clinic Foundation
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- Abbott, Christopher C. (författare)
- University of New Mexico
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- van Eijndhoven, Philip F.P. (författare)
- Radboud University Nijmegen,Radboud University Medical Center
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- Tendolkar, Indira (författare)
- Radboud University Medical Center,Radboud University Nijmegen,University Hospital Essen
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 9 s.
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Ingår i: Brain Stimulation. - : Elsevier BV. - 1935-861X. ; 13:3, s. 696-704
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. Objective: To determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic resonance imaging (MRI) and, if so, which regions are related to this clinical effect. We also determine whether a similar model can be used to identify regions associated with electrode placement (unilateral versus bilateral ECT). Methods: Longitudinal MRI and clinical data (Hamilton Depression Rating Scale) was collected from 10 sites as part of the Global ECT-MRI research collaboration (GEMRIC). From 192 subjects, relative changes in 80 (sub)cortical areas were used as potential features for classifying treatment response. We used recursive feature elimination to extract relevant features, which were subsequently used to train a linear classifier. As a validation, the same was done for electrode placement. We report accuracy as well as the structural coefficients of regions included in the discriminative spatial patterns obtained. Results: A pattern of structural changes in cortical midline, striatal and lateral prefrontal areas discriminates responders from non-responders (75% accuracy, p < 0.001) while left-sided mediotemporal changes discriminate unilateral from bilateral electrode placement (81% accuracy, p < 0.001). Conclusions: The identification of a multivariate discriminative pattern shows that structural change is relevant for clinical response to ECT, but this pattern does not include mediotemporal regions that have been the focus of electroconvulsive therapy research so far.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Depression
- Electroconvulsive therapy
- Major depressive disorder
- MRI
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mulders, Peter C ...
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Llera, Alberto
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Beckmann, Christ ...
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Vandenbulcke, Ma ...
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Stek, Max
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Sienaert, Pascal
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visa fler...
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Redlich, Ronny
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Petrides, Georgi ...
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Oudega, Mardien ...
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Oltedal, Leif
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Oedegaard, Ketil ...
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Narr, Katherine ...
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Magnusson, Peter ...
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Kessler, Ute
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Jorgensen, Ander ...
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Espinoza, Randal ...
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Enneking, Verena
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Emsell, Louise
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Dols, Annemieke
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Dannlowski, Udo
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Bolwig, Tom G.
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Bartsch, Hauke
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Argyelan, Miklos
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Anand, Amit
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Abbott, Christop ...
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van Eijndhoven, ...
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Tendolkar, Indir ...
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visa färre...
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