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- Merclin, Nadia, et al.
(författare)
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Transdermal delivery from a lipid sponge phaseiontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester
- 2004
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Ingår i: Journal of Controlled Release. - : Elsevier BV. - 0168-3659 .- 1873-4995. ; 100:2, s. 191-198
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Tidskriftsartikel (refereegranskat)abstract
- The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein, propylene glycol and aqueous buffer at concentrations of approximately 0.25% and 16% w/w m-ALA. The iontophoretic and passive delivery of ALA and m-ALA from this formulation through porcine skin in vitro were measured and compared to formulations used in clinical practice, 20% w/w ALA in Unguentum M and Metvix(R) (a cream containing 16% w/w m-ALA). A sponge phase with 16% w/w m-ALA showed a higher passive flux (approximately 140 nmol cm(-2) h(-1) at 5 h) but a lower iontophoretic flux (approximately 800 nmol cm(-2) h(-1) at 5 h) compared to the clinically used products but the differences are hardly significant due to large standard deviations. ALA and m-ALA in sponge phase formulation showed iontophoretic fluxes in the range 80-100 nmol cm(-2) h(-1) at 3 h, i.e. values comparable to the passive fluxes from the more concentrated vehicles. The results demonstrate that the lipid sponge phase, a thermodynamically stable liquid with amphiphilic character, may have potential as a transdermal drug delivery vehicle.
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- Pettersson, Hans-Åke, et al.
(författare)
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Blomatic. Ett alternativ
- 1978
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Consumer report ("avnämarrapport" in Swedish) for the company who financed this evaluation report.
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- Skoglundh, Magnus, 1965, et al.
(författare)
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An investigation of the NOx storage mechanism
- 1998
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Ingår i: American Vacuum Society 45th International Symposium in Baltimore, Maryland, USA, November 2-6, 1998..
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Konferensbidrag (refereegranskat)
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