1. |
- Kalenga, T. M., et al.
(författare)
-
Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis
- 2022
-
Ingår i: Journal of Natural Products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 85:9, s. 2135-2141
-
Tidskriftsartikel (refereegranskat)abstract
- The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and fi-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 mu g/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 mu g/ mL. The isolated compounds 1-3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at >= 100 mu M.
|
|
2. |
- Zandi, Linda, et al.
(författare)
-
Secoiridoids and Iridoids from Morinda asteroscepa
- 2020
-
Ingår i: Journal of Natural Products. - : AMER CHEMICAL SOC. - 0163-3864 .- 1520-6025. ; 83:9, s. 2641-2646
-
Tidskriftsartikel (refereegranskat)abstract
- The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4-7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 mu g/mL) and compounds 1-3 and 5 (10 mu M) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).
|
|