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Natural disease cou...
Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study
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- Burisch, J (författare)
- Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark
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- Kiudelis, G (författare)
- Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
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- Kupcinskas, L (författare)
- Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
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visa fler...
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- Kievit, HAL (författare)
- Department of Medicine, Herning Central Hospital, Herning, Denmark
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- Andersen, KW (författare)
- Medical Department, Regional Hospital of Viborg, Viborg, Denmark
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- Andersen, V (författare)
- Medical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused research unit for Molecular Diagnostic and Clinical Research (MOK), IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark
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- Salupere, R (författare)
- Division of Gastroenterology, Tartu University Hospital, University of Tartyu, Tartu, Estonia
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- Pedersen, N (författare)
- Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark
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- Kjeldsen, J (författare)
- Gastroenterology Department, Odense University Hospital, Odense, Denmark
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- D'Inca, R (författare)
- Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy,IBD Clinical and Research Centre (ISCARE), Prague, Czech Republic
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- Valpiani, D (författare)
- U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy
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- Schwartz, D (författare)
- Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
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- Odes, S (författare)
- Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
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- Olsen, J (författare)
- Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark
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- Nielsen, KR (författare)
- Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark
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- Vegh, Z (författare)
- 1st Department of Medicine, Semmelweis University, Budapest, Hungary
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- Lakatos, PL (författare)
- 1st Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, Canada
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- Toca, A (författare)
- Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova
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- Turcan, S (författare)
- Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova
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- Katsanos, KH (författare)
- Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece
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- Christodoulou, DK (författare)
- Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece
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- Fumery, M (författare)
- Gastroenterology Unit, Epimad Registry, Centre hospitalier universitaire (CHU) Amiens Sud, Amiens University Hospital, Amiens, France
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- Gower-Rousseau, C (författare)
- Public Health, Epidemiology and Economic Health, Registre Epimad, Lille Hospital, Lille University, Lille, France; Lille Inflammation Research International Center (LIRIC), Lille University, Lille, France
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- Zammit, SC (författare)
- Division of Gastroenterology, Mater Dei Hospital, Msida, Malta,IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK
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- Ellul, P (författare)
- Division of Gastroenterology, Mater Dei Hospital, Msida, Malta
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- Eriksson, Carl, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Magro, FJ (författare)
- Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine, Porto University, Porto, Portugal
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Duricova, D (författare)
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- Bortlik, M (författare)
- IBD Clinical and Research Centre (ISCARE), Prague, Czech Republic; Institute of Pharmacology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
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- Fernandez, A (författare)
- Department of Gastroenterology, Hospital POVISA, Vigo, Spain
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- Hernandez, V (författare)
- Department of Gastroenterology, Hospital Alvaro Cunqueiro. Instituto Investigación Sanitaria Galicia Sur. EOXI de Vigo, Vigo, Spain
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- Myers, S (författare)
- IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK
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Sebastian, S (författare)
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- Oksanen, P (författare)
- Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland
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- Collin, P (författare)
- University of Tampere, Tampere, Finland
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- Goldis, A (författare)
- Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania
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- Misra, R (författare)
- IBD Department, Imperial College London, London, UK
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- Arebi, N (författare)
- IBD Department, Imperial College London, London, UK
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- Kaimakliotis, IP (författare)
- Nicosia private practice, Nicosia, Cyprus
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- Nikuina, I (författare)
- Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation
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- Belousova, E (författare)
- Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation
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- Brinar, M (författare)
- Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia
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- Cukovic-Cavka, S (författare)
- Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia
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- Langholz, E (författare)
- Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark
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- Munkholm, P (författare)
- Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark
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Niewiadomski, O (författare)
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Bell, S (författare)
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Turk, N (författare)
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Cukovic-Cavka, S (författare)
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Kaimakliotis, I (författare)
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Nicolaou, A (författare)
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Duricova, D (författare)
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Lukas, M (författare)
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Bortlik, M (författare)
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Shonova, O (författare)
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Burisch, J (författare)
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Munkholm, P (författare)
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Langholz, E (författare)
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Blichfeldt, B (författare)
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Marker, D (författare)
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Carlsen, K (författare)
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Weimers, P (författare)
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Pedersen, N (författare)
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Kjeldsen, J (författare)
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Aalykke, C (författare)
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Dahlerup, JF (författare)
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Kudsk, K (författare)
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Andersen, V (författare)
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Vind, I (författare)
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Thorsgaard, N (författare)
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Salupere, R (författare)
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Olsen, J (författare)
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Nielsen, KR (författare)
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Oksanen, P (författare)
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Collin, P (författare)
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Katsanos, KH (författare)
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Christodoulou, DK (författare)
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Skamnelos, A (författare)
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Politis, D (författare)
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Ladefoged, K (författare)
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Lakatos, PL (författare)
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Vegh, Z (författare)
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Lakatos, L (författare)
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Demenyi, P (författare)
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Kramli, SN (författare)
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O'Morain, C (författare)
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Dal Piaz, G (författare)
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Santini, A (författare)
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Girardin, G (författare)
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D'Inca, R (författare)
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Schwartz, D (författare)
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Odes, S (författare)
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Kupcinskas, L (författare)
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Jonaitis, L (författare)
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Kiudelis, G (författare)
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Valantiene, I (författare)
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(creator_code:org_t)
- 2018-01-23
- 2019
- Engelska.
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Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 68:3, s. 423-433
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn’s disease (CD).DesignPatients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.ResultsIn total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5).ConclusionDespite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Crohn’s disease
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Burisch, J
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Kiudelis, G
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Kupcinskas, L
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Kievit, HAL
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Andersen, KW
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Andersen, V
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visa fler...
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Salupere, R
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Pedersen, N
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Kjeldsen, J
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D'Inca, R
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Valpiani, D
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Schwartz, D
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Odes, S
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Olsen, J
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Nielsen, KR
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Vegh, Z
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Lakatos, PL
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Toca, A
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Turcan, S
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Katsanos, KH
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Christodoulou, D ...
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Fumery, M
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Gower-Rousseau, ...
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Zammit, SC
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Ellul, P
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Eriksson, Carl, ...
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Halfvarson, Jona ...
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Magro, FJ
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Duricova, D
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Bortlik, M
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Fernandez, A
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Hernandez, V
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Myers, S
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Sebastian, S
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Oksanen, P
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Collin, P
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Goldis, A
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Misra, R
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Arebi, N
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Kaimakliotis, IP
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Nikuina, I
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Belousova, E
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Brinar, M
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Cukovic-Cavka, S
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Langholz, E
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Munkholm, P
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Niewiadomski, O
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Bell, S
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Turk, N
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Kaimakliotis, I
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Nicolaou, A
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Lukas, M
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Shonova, O
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Blichfeldt, B
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Marker, D
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Carlsen, K
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Weimers, P
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Aalykke, C
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Dahlerup, JF
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Kudsk, K
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Vind, I
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Thorsgaard, N
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Skamnelos, A
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Politis, D
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Ladefoged, K
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Lakatos, L
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Demenyi, P
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Kramli, SN
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O'Morain, C
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Dal Piaz, G
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Santini, A
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Girardin, G
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Jonaitis, L
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Valantiene, I
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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MEDICIN OCH HÄLS ...
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och Folkhälsovetensk ...
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