| 1. |
- Duracz, A., et al.
(author)
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Advanced Hazard Analysis and Risk Assessment in the ISO 26262 Functional Safety Standard Using Rigorous Simulation
- 2020
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In: Cyber Physical Systems. Model-Based Design. - Berlin : Springer. - 9783030411305 ; 11971, s. 108-126
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Conference paper (peer-reviewed)abstract
- With the increasing level of automation in road vehicles, the traditional workhorse of safety assessment, namely, physical testing, is no longer adequate as the sole means of ensuring safety. A standard safety assessment benchmark is to evaluate the behavior of a new design in the context of a risk-exposing test scenario. Manual or computerized analysis of the behavior of such systems is challenging because of the presence of non-linear physical dynamics, computational components, and impacts. In this paper, we study the utility of a new technology called rigorous simulation for addressing this problem. Rigorous simulation aims to combine some of the benefits of traditional simulation methods with those of traditional analytical methods such as symbolic algebra. We develop and analyze in detail a case study involving an Intersection Collision Avoidance (ICA) test scenario using the hazard analysis techniques prescribed in the ISO 26262 functional safety standard. We show that it is possible to formally model and rigorously simulate the test scenario to produce informative results about the severity of collisions. The work presented in this paper demonstrates that rigorous simulation can handle models of non-trivial complexity. The work also highlights the practical challenges encountered in using it. © 2020, Springer Nature Switzerland AG.
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| 2. |
- Eriksson, Peder, et al.
(author)
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Temporal changes and spatial variation of soil oxygen consumption, nitrification and denitrification rates in a tidal salt marsh of the Lagoon of Venice, Italy
- 2003
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In: Estuarine, Coastal and Shelf Science. - : Elsevier. - 0272-7714 .- 1096-0015. ; 58:4, s. 861-871
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Journal article (peer-reviewed)abstract
- The aim of the present study was to investigate seasonal and spatial patterns of soil oxygen consumption, nitrification, denitrification and fluxes of dissolved inorganic nitrogen (DIN) in a tidal salt marsh of the Lagoon of Venice, Italy. In the salt marsh, intact soil cores including overlying water were collected monthly at high tide from April to October in salt marsh creeks and in areas covered by the dominant vegetation, Limonium serotinum. In May, cores were also collected in areas with vegetation dominated by Juncus maritimus and Halimione portulacoides. In laboratory incubations at in situ temperature in the dark, flux rates of oxygen and DIN were monitored in the overlying water of the intact cores. 15N-nitrate was added to the overlying water and nitrification and denitrification were measured using isotope-dilution and -pairing techniques. The results show that highest soil oxygen consumption coincided with the highest water temperature in June and July. The highest denitrification rates were recorded in spring and autumn coinciding with the highest nitrate concentrations. Soil oxygen consumption and nitrification rates differed between sampling sites, but denitrification rates were similar among the different vegetation types. The highest rates were recorded in areas covered with L. serotinum. Burrowing soil macrofauna enhanced oxygen consumption, nitrification and denitrification in April and May. The data presented in this study indicate high temporal as well as spatial variations in the flux of oxygen and DIN, and nitrogen transformations in the tidal salt marshes of the Venice lagoon during the growth season. The results identify the salt marshes of the Venice lagoon as being metabolically very active ecosystems with a high capacity to process nitrogen.
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| 3. |
- Ihlström Eriksson, Carina, 1960-, et al.
(author)
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Forming a Value Network - Analyzing the Negotiations Between Actors in the E-Newspaper Case
- 2009
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In: Proceedings of the 42nd Annual Hawaii International Conference on System Sciences, HICSS. - Los Alamitos, Calif. : IEEE Computer Society. - 9780769534503 ; , s. 1-10
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Conference paper (peer-reviewed)abstract
- We have studied a two-year project aiming at exploring the potentials of the e-newspaper, i.e. a news service published with e-paper technology. Different actors have interests in this process, e.g. newspaper publishers, device producers, readers and advertisers. These actors are forming value networks by negotiations of interests and positions. The contribution of the paper is twofold: firstly we show how the value network created around e-newspaper is dependent on the convergence of different actors and their interests; secondly our theoretical contribution is to show how Actor Network Theory (ANT) can be used in combination with other theories - in this case genre theory - to analyze emergent value networks. ANT captures the general process of how the value network takes form, while genre theory captures the domain specific context of e-newspapers, and how this structures negotiations between different stakeholders who want to form the e-newspaper genre.
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| 4. |
- Karagianni, Alexia, 1980, et al.
(author)
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Long-term outcome after closure of an atrial shunt in patients aged 60 years or older with ischemic stroke: A nationwide, registry-based, case-control study
- 2023
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In: International Journal of Cardiology Congenital Heart Disease. - Amsterdam : Elsevier. - 2666-6685. ; 11
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Journal article (peer-reviewed)abstract
- Background: According to the current guidelines, evidence of the effects of transcatheter closure in patients aged ≥60 years with an atrial shunt and cryptogenic stroke is still limited. Methods: Using Swedish health registries, patients aged ≥60 years who had previously developed a cryptogenic cerebrovascular event and undergone transcatheter closure were identified. Patients with atrial fibrillation were excluded, and the remaining patients were propensity score-matched with patients of the same age and risk profile who had only undergone medical treatment and with controls from the general population. They were then followed up until 2017 (mean period of 7.1 ±3.9 years). Results: In total, 100 patients of the intervention group were matched with 100 patients of the medical treatment group and with 100 controls and followed up. The hazard ratio for a recurrent ischemic stroke in the intervention group compared with the medical treatment group was 0.8 (95% confidence interval, 0.3–2.1), and that compared with the controls was 2.3 (95% confidence interval, 0.6–8.9). Atrial fibrillation occurred at the same rate in the two treatment groups (odds ratio, 0.8; 95% confidence interval, 0.4–1.7). However, patients in the intervention group developed vascular disease at a lower rate (odds ratio, 0.5; 95% confidence interval, 0.25–0.85). Conclusions: Patients aged ≥60 years with cryptogenic stroke may undergo transcatheter closure of an atrial shunt after thorough screening for other potential causes of stroke. The incidence of vascular disease seems to be mitigated in these patients relative to medically treated patients. © 2023 The Authors. Published by Elsevier B.V.
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| 5. |
- Karagianni, Alexia, 1980, et al.
(author)
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Percutaneous atrial shunt closure and the risk of recurrent ischemic stroke : A register-based, nationwide cohort study
- 2023
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In: Journal of Stroke & Cerebrovascular Diseases. - Philadelphia : Elsevier. - 1052-3057 .- 1532-8511. ; 32:6
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Journal article (peer-reviewed)abstract
- Background: According to the current guidelines, evidence of the effects of transcatheter closure in patients aged ≥60 years with an atrial shunt and cryptogenic stroke is still limited. Methods: Using Swedish health registries, patients aged ≥60 years who had previously developed a cryptogenic cerebrovascular event and undergone transcatheter closure were identified. Patients with atrial fibrillation were excluded, and the remaining patients were propensity score-matched with patients of the same age and risk profile who had only undergone medical treatment and with controls from the general population. They were then followed up until 2017 (mean period of 7.1 ±3.9 years). Results: In total, 100 patients of the intervention group were matched with 100 patients of the medical treatment group and with 100 controls and followed up. The hazard ratio for a recurrent ischemic stroke in the intervention group compared with the medical treatment group was 0.8 (95% confidence interval, 0.3–2.1), and that compared with the controls was 2.3 (95% confidence interval, 0.6–8.9). Atrial fibrillation occurred at the same rate in the two treatment groups (odds ratio, 0.8; 95% confidence interval, 0.4–1.7). However, patients in the intervention group developed vascular disease at a lower rate (odds ratio, 0.5; 95% confidence interval, 0.25–0.85). Conclusions: Patients aged ≥60 years with cryptogenic stroke may undergo transcatheter closure of an atrial shunt after thorough screening for other potential causes of stroke. © 2023 The Authors
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| 6. |
- Tonderski, Karin S., et al.
(author)
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Våtmarker : Närsaltsfällor och/eller myllrande mångfald?
- 2003
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In: Vatten: tidskrift för vattenvård. - Nykvarn : Föreningen Vatten. - 0042-2886. ; 59:4, s. 259-270
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Journal article (peer-reviewed)abstract
- This paper summarizes the state-of-the-art with respect to wetlands for nutrient removal and biodiversity enhancement, as expressed at a research workshop in December 2002. In the end of 2002, 260 and 884 wetlands had been constructed in Sweden with subsidies from LIP and the European Union, respectively. Most frequently, the aims were to remove nutrients from water and enhance biodiversity. The question raised is if we know how to design multifunctional wetlands. Should a wetland be deep or shallow, with or without macrophytes to be an efficient nutrient sink? Diverging opinions are presented, but generally it appears that fairly shallow wetlands at least partly covered by emergent macrophytes are favourable. The importance of extreme high flows and hydraulic short-circuiting is highlighted, and Danish and Norwegian approaches to wetlands construction are presented. Also, there is a risk that nutrient retaining wetlands develop a fairly trivial flora and fauna unless special care is taken. Intentional establishment of desirable and less common species, as well as creation of a variation of depth gradients to favour such species are such measures. Others are allowing for water level variations, as well as vegetation management such as grazing and harvesting.
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| 7. |
- Ursby, Thomas, et al.
(author)
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BioMAX the first macromolecular crystallography beamline at MAX IV Laboratory
- 2020
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In: Journal of Synchrotron Radiation. - Chichester : Wiley-Blackwell. - 0909-0495 .- 1600-5775. ; 27, s. 1415-1429
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Journal article (peer-reviewed)abstract
- BioMAX is the first macromolecular crystallography beamline at the MAX IV Laboratory 3 GeV storage ring, which is the first operational multi-bend achromat storage ring. Due to the low-emittance storage ring, BioMAX has a parallel, high-intensity X-ray beam, even when focused down to 20 μm × 5 μm using the bendable focusing mirrors. The beam is tunable in the energy range 5-25 keV using the in-vacuum undulator and the horizontally deflecting double-crystal monochromator. BioMAX is equipped with an MD3 diffractometer, an ISARA high-capacity sample changer and an EIGER 16M hybrid pixel detector. Data collection at BioMAX is controlled using the newly developed MXCuBE3 graphical user interface, and sample tracking is handled by ISPyB. The computing infrastructure includes data storage and processing both at MAX IV and the Lund University supercomputing center LUNARC. With state-of-the-art instrumentation, a high degree of automation, a user-friendly control system interface and remote operation, BioMAX provides an excellent facility for most macromolecular crystallography experiments. Serial crystallography using either a high-viscosity extruder injector or the MD3 as a fixed-target scanner is already implemented. The serial crystallography activities at MAX IV Laboratory will be further developed at the microfocus beamline MicroMAX, when it comes into operation in 2022. MicroMAX will have a 1 μm × 1 μm beam focus and a flux up to 1015 photons s with main applications in serial crystallography, room-temperature structure determinations and time-resolved experiments.
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