| 1. |
- D'Elia, Domenica, et al.
(författare)
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The 20th anniversary of EMBnet : 20 years of bioinformatics for the Life Sciences community
- 2009
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Ingår i: BMC Bioinformatics. - 1471-2105. ; 10:Suppl. 6, s. S1-
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Tidskriftsartikel (refereegranskat)abstract
- The EMBnet Conference 2008, focusing on 'Leading Applications and Technologies in Bioinformatics', was organized by the European Molecular Biology network (EMBnet) to celebrate its 20th anniversary. Since its foundation in 1988, EMBnet has been working to promote collaborative development of bioinformatics services and tools to serve the European community of molecular biology laboratories. This conference was the first meeting organized by the network that was open to the international scientific community outside EMBnet. The conference covered a broad range of research topics in bioinformatics with a main focus on new achievements and trends in emerging technologies supporting genomics, transcriptomics and proteomics analyses such as high-throughput sequencing and data managing, text and data-mining, ontologies and Grid technologies. Papers selected for publication, in this supplement to BMC Bioinformatics, cover a broad range of the topics treated, providing also an overview of the main bioinformatics research fields that the EMBnet community is involved in.
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| 2. |
- Eriksson, Kimmo, 1967-, et al.
(författare)
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Appropriateness ratings of everyday behaviors in the United States now and 50 years ago
- 2023
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Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: A crucial aspect of social norms pertains to determining which behaviors are considered appropriate. Here we consider everyday behaviors. Some everyday behaviors are rated as more appropriate than others, and ratings of the appropriateness of a given behavior may vary over time. The objective of this study is to elucidate the reasons behind variation in appropriateness ratings of everyday behaviors in the United States. Our theory focuses on how the evaluation of the appropriateness of a behavior is influenced by its potential for externalities and internalities, and how this influence may cause a change in norms over time.Method: Employing a preregistered design, we asked American participants to rate 37 different everyday behaviors based on their appropriateness in a range of common situations, as well as their potential negative externalities (e.g., being loud, being aggressive, taking up space) and positive internalities (e.g., pleasurability). Changes over time were calculated as the difference between mean ratings obtained in this study and ratings of the same behavior in a similar study conducted 50 years ago.Results: As expected, overall appropriateness ratings of everyday behaviors are associated both with their externalities and their internalities, so that the least appropriate behaviors tend to have considerable potential for negative externalities and little potential for positive internalities. Moreover, behaviors that have considerable potential for negative externalities are perceived as less appropriate now than 50 years ago.Discussion: By describing how social norms for everyday behaviors depend on the externalities and internalities of behaviors, this study contributes to theories about the emergence and change of social norms.
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| 3. |
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| 4. |
- Eriksson, Kimmo, 1967-, et al.
(författare)
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The common-is-moral association is stronger among less religious people
- 2021
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Ingår i: Humanities and Social Sciences Communications. - : Springer Nature. - 2662-9992. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Questionable behaviours that are perceived as more common also tend to be judged as more morally justified. Here we explore this phenomenon in survey data from 31 countries in the European Values Study, allowing us to examine the universality of the common-is-moral association. More than 35,000 participants rated eight questionable behaviours (e.g., cheating on taxes, having casual sex) on how frequent they are and how justified they are. We estimated common-is-moral associations both across individuals for each behaviour and across behaviours within each individual; in both cases, the association tended to be positive. We further examined the hypothesis that the common-is-moral association would be stronger among less religious people, who are less likely to adopt their moral judgements from religious authorities and therefore should be more susceptible to the heuristic of using the perceived commonness of a behaviour as a guide to how it should be morally judged. Indeed, we found the common-is-moral association to be somewhat stronger among less religious people, whether the association was estimated across individuals or within individuals. We discuss alternative explanations, implications and directions for future research.
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| 5. |
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| 6. |
- Huuhtanen, Jani, et al.
(författare)
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IFN-alfa with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia
- 2022
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Ingår i: Journal of Clinical Investigation. - : AMER SOC CLINICAL INVESTIGATION INC. - 0021-9738 .- 1558-8238. ; 132:17
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Tidskriftsartikel (refereegranskat)abstract
- In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-alpha is one promising candidate, as it has long-lasting effects on both malignant and immune cells. In connection with a multicenter clinical trial combining dasatinib with IFN-alpha in 40 patients with chronic-phase CML (NordCML007, NCT01725204), we performed immune monitoring with single-cell RNA and T cell receptor (TCR) sequencing (n = 4, 12 samples), bulk TCR beta sequencing (n = 13, 26 samples), flow cytometry (n = 40, 106 samples), cytokine analyses (n = 17, 80 samples), and ex vivo functional studies (n = 39, 80 samples). Dasatinib drove the immune repertoire toward terminally differentiated NK and CD8+ T cells with dampened functional capabilities. Patients with dasatinib-associated pleural effusions had increased numbers of CD8(+) recently activated effector memory T (Temra) cells. In vitro, dasatinib prevented CD3-induced cell death by blocking TCR signaling. The addition of IFN-alpha reversed the terminally differentiated phenotypes and increased the number of costimulatory intercellular interactions and the number of unique putative epitope-specific TCR clusters. In vitro IFN-alpha had costimulatory effects on TCR signaling. Our work supports the combination of IFN-alpha with TKI therapy, as IFN-alpha broadens the immune repertoire and restores immunological function.
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| 7. |
- Krueger, Joel, et al.
(författare)
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Acculturation of hygiene norms among immigrants to Sweden
- 2023
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Hygiene norms in Sweden are generally loose compared to most other countries. Does this looseness affect the hygiene norms among people who immigrate to Sweden from other countries? In a study of hygiene norms among immigrants to Sweden, the change in the physical environment and material living conditions, acculturation to Swedish culture and norms, and selection effects were all expected to lead immigrant hygiene norms to be closer to Swedish looseness. However, in a sample of 447 immigrants from 12 different countries, immigrants reported hygiene norms that were even stricter than those found in their countries of origin. We propose an explanation based on a combination of uncertainty about prevailing hygiene norms and the social risk and stigma associated with being perceived as unhygienic. We conclude that acculturation processes may rely on mechanisms that are domain specific.
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| 8. |
- Law, Philip J., et al.
(författare)
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Association analyses identify 31 new risk loci for colorectal cancer susceptibility
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
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| 9. |
- Lindvall, Jannika, 1987-, et al.
(författare)
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Does the duration of professional development programs influence effects on instruction? : An analysis of 174 lessons during a national-scale program
- 2023
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Ingår i: European Journal of Teacher Education. - : Taylor & Francis Group. - 0261-9768 .- 1469-5928. ; , s. 1-19
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Tidskriftsartikel (refereegranskat)abstract
- We examine the effects of a year-long national-scale professional development (PD) program on mathematics instructional quality. In contrast to previous studies examining the effects of this program on instruction by comparing before and after participation or parti-cipants and non-participants, we examine whether instructional quality changed during the program. More specifically, we conduct an analysis of 174 video-recorded mathematics lessons given by 52 teachers during their year of participation. Contrary to previous studies, the results demonstrate that the instructional quality did not improve over the course of the PD. We suggest that the explanations for the diverging results concern how, when, and to what extent instructional quality changes in PD programs. Specifically, we discuss how the explanations may illuminate the significance of PD duration for PD effects, and how these effects may be mediated by features concerning the PD content and the scale at which the program is implemented.
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| 10. |
- Simonsson, Bengt, et al.
(författare)
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Combination of pegylated IFN-alpha 2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia
- 2011
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Ingår i: Blood. - Washington D.C. : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 118:12, s. 3228-3235
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Tidskriftsartikel (refereegranskat)abstract
- Biologic and clinical observations suggest that combining imatinib with IFN-alpha may improve treatment outcome in chronic myeloid leukemia (CML). We randomized newly diagnosed chronic-phase CML patients with a low or intermediate Sokal risk score and in imatinib-induced complete hematologic remission either to receive a combination of pegylated IFN-alpha 2b (Peg-IFN-alpha 2b) 50 mu g weekly and imatinib 400 mg daily (n = 56) or to receive imatinib 400 mg daily monotherapy (n = 56). The primary endpoint was the major molecular response (MMR) rate at 12 months after randomization. In both arms, 4 patients (7%) discontinued imatinib treatment (1 because of blastic transformation in imatinib arm). In addition, in the combination arm, 34 patients (61%) discontinued Peg-IFN-alpha 2b, most because of toxicity. The MMR rate at 12 months was significantly higher in the imatinib plus Peg-IFN-alpha 2b arm (82%) compared with the imatinib monotherapy arm (54%; intention-to-treat, P = .002). The MMR rate increased with the duration of Peg-IFN-alpha 2b treatment (andlt; 12-week MMR rate 67%, andgt; 12-week MMR rate 91%). Thus, the addition of even relatively short periods of Peg-IFN-alpha 2b to imatinib markedly increased the MMR rate at 12 months of therapy. Lower doses of Peg-IFN-alpha 2b may enhance tolerability while retaining efficacy and could be considered in future protocols with curative intent.
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