| 1. |
- Zhao, J. H., et al.
(författare)
-
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
- 2023
-
Ingår i: Nature Immunology. - : Springer Nature. - 1529-2908 .- 1529-2916. ; 24:9, s. 1540-1551
-
Tidskriftsartikel (refereegranskat)abstract
- Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-alpha in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis versus multiple sclerosis and inflammatory bowel disease. MR implicated CXCL5 in the etiology of ulcerative colitis (UC) and we show elevated gut CXCL5 transcript expression in patients with UC. These results identify targets of existing drugs and provide a powerful resource to facilitate future drug target prioritization. Here the authors identify genetic effectors of the level of inflammation-related plasma proteins and use Mendelian randomization to identify proteins that contribute to immune-mediated disease risk.
|
|
| 2. |
|
|
| 3. |
- Eriksson, Lina M., 1978-
(författare)
-
Election Report Sweden
- 2019
-
Ingår i: Scandinavian Political Studies. - : Wiley. - 0080-6757 .- 1467-9477. ; 42:1, s. 84-88
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
- Eriksson, Lina M., 1978-, et al.
(författare)
-
Let Me Be the Judge : Ideology, Identity, and Judicial Selection
- 2023
-
Ingår i: Journal of Experimental Political Science. - : Cambridge University Press. - 2052-2630 .- 2052-2649. ; 10:2, s. 221-230
-
Tidskriftsartikel (refereegranskat)abstract
- A substantial body of research has found biased recruitment in a variety of societal spheres. We study selection in the judiciary, a domain that has received less attention than the economic and political spheres. Our field experiment took place in the midst of a Swedish government campaign encouraging ordinary citizens to contact local parties, which are responsible for recruiting lay judges (jurors) and put themselves forward as lay judge candidates. Parties’ responsiveness to citizen requests does not seem to favor their own sympathizers, does not vary at all with signals of gender, and is only marginally affected by ethnicity and age. Given the potential importance of ideology and identity in judicial decision-making, the finding that there is little bias with respect to these factors at this first stage of the recruitment process is reassuring from the perspective of impartiality.
|
|
| 5. |
- Eriksson, Lina M., 1978-
(författare)
-
Natural Disasters and National Election : On the 2004 Indian Ocean Boxing Day Tsunami, the 2005 Storm Gudrun and the 2006 Historic Regime Shift
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The 2006 Swedish parliamentary election was a historic election with the largest bloc transfer of voters in Swedish history. The 2002-2006 incumbent Social Democratic Party (S) received its lowest voter support since 1914 as roughly 150,000, or 8%, of the 2002 S voters went to the main opposition, the conservative Moderate Party (M). This became the most decisive factor in ousting S from power after 12 years of rule. As a result, the M-led Alliance (A) with the People's Party (FP), the Center Party (C), and the Christian Democrats (KD) won the election. Natural Disasters and National Election makes the novel contribution of proposing two natural disasters, the Indian Ocean’s 2004 Boxing Day Tsunami and 2005 Storm Gudrun (Erwin), which struck only two weeks following the tsunami, as major events that impacted government popularity in the 2006 election and contributed to the redistribution of voter support, within and across party-blocs. The core findings from this thesis show that the S government’s poor crisis response to Gudrun, which is the hitherto most costly natural disaster in Swedish history, alone has an estimated effect of a magnitude that likely contributed to the 2006 historic regime shift, while the tsunami also seems to have mattered. The tsunami is particularly interesting, as S’s poor international crisis response to the event constitutes the first natural disaster situation to knowingly have affected an election on the other side of the planet. Moreover, to some degree voters recognized the active opposition by C as effective representation and rewarded the party for its strong stance on the poor handling of both events by S. In fact, the active voice of C concerning these disasters likely helped move the party from the periphery of party politics to becoming the third-largest party in Swedish politics. In sum, this research investigates accountability and effective party representation via retrospective voting, which is an essential mechanism for the legitimacy of democracy. Findings suggest that the average Swedish voter indeed may be voting retrospectively to hold publically elected officials accountable, which suggest a healthy status of the retrospective voting mechanism and Swedish democracy.
|
|
| 6. |
|
|
| 7. |
- Eriksson, Lina M., 1978-, et al.
(författare)
-
Welcome to the Party? Ethnicity and the Interaction between Potential Activists and Party Gate-Keepers
- 2021
-
Ingår i: Journal of Politics. - : University of Chicago Press. - 0022-3816 .- 1468-2508. ; 83:4, s. 1861-1866
-
Tidskriftsartikel (refereegranskat)abstract
- In modern democracies, political parties are the vehicles through which new groups gain political entry. Are parties equally welcoming to all new activists, irrespective of their ethnicity? In a field experiment, we study the responsiveness of local party officials in Sweden who are being contacted by fictitious individuals who want to become active in the party. We find that party officials are more likely to respond, and give informative answers that use a warmer and more welcoming tone, when they are being contacted by an individual with a Swedish name than by an individual with an Arabic name. These discriminatory effects are mainly found when contacting parties on the rightmost end of the political spectrum but are unaffected by appeals to electoral gain, common ideology, and norms of democratic inclusion. Given the importance of parties as gateways into politics, our findings have troubling implications for equal representation.
|
|
| 8. |
|
|
| 9. |
- Eriksson, Lina M., 1978-
(författare)
-
Winds of Change : Voter Blame and Storm Gudrun in the 2006 Swedish Parliamentary Election
- 2016
-
Ingår i: Electoral Studies. - : Elsevier BV. - 0261-3794 .- 1873-6890. ; 41, s. 129-142
-
Tidskriftsartikel (refereegranskat)abstract
- Can a natural disaster shift long-standing party support for the long-term? Studies of political behavior indicate that, as elections approach, voters punish or credit governments based on their responses to severe weather phenomena. It may still be considered an open question, however, if poor crisis response could trigger more durable shifts in long-standing party support. I provide empirical evidence suggesting that it could. I exploit a crucial case for the study of change in party support, Storm Gudrun (Erwin), to examine long lasting punishment effects over crisis response. The estimated effect is of a magnitude that equals the largest block-transfer of voters in Swedish history and can be seen over three parliamentary elections (2006, 2010 and 2014).
|
|
