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Sökning: WFRF:(Eriksson Mathilda)

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1.
  • Curtis, Maurice A, et al. (författare)
  • Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension.
  • 2007
  • Ingår i: Science (New York, N.Y.). - 1095-9203. ; 315:5816, s. 1243-9
  • Tidskriftsartikel (refereegranskat)abstract
    • The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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2.
  • Eriksson, Mathilda (författare)
  • Cancer therapy using viral- and bacterial proteins, as vectors for vaccines or as carriers of cytostatics
  • 2012
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • New cancer therapies are urgently needed, since available treatment options today have negative side effects, and cure only about half of the patients with invasive cancer. One, relatively new, option is to vaccinate against cancer, by introducing an antigen that is present on the tumor cells into the patient to stimulate specific immunity against the tumor. For this purpose viral capsid proteins, which can self-assemble into so called virus-like particles (VLPs), can be engineered to contain tumor antigens in the form of DNA, whole protein or peptides and be used as vaccines. Here, VLPs based on murine polyomavirus (MPyV) and murine pneumotropic virus (MPtV) containing the extracellular and transmembrane part of the breast cancer antigen Her2/neu, or the whole prostate cancer antigen PSA, have been produced. As mentioned above there are side effects with cancer treatment, and the use of the common cytostatic anti-cancer drug Cisplatin has a number of side effects, including; nephrotoxicity (kidney damage); neurotoxicity (nerve damage); and ototoxicity (hearing loss). To possibly inhibit some of this toxicity we attempted to make use of the “enhanced permeability and retention” (EPR) effect that causes macromolecules to accumulate more in tumor tissue than in normal tissue, since tumor blood vessels are leaky, and tumors lack effective lymphatic drainage. The use of a macromolecule as a carrier for Cisplatin would therefore hold the potential to reduce some of its negative side effects. For this purpose it was investigated whether the macromolecule right-handed coiled coil “RHCC” protein from bacterium Staphylothermus marinus, that can incorporate heavy metals, would also incorporate cisplatin containing the metal platinum. The overall aim of the first three papers in this thesis was to develop and determine preclinical efficacy of MPyV- and MPtV-VLPs carrying Her2/neu or PSA against tumors expressing these tumor antigens. The overall aim of paper IV was to investigate RHCC’s potential to carry cisplatin efficiently to tumors, while retaining the cytotoxic effect of the drug. In paper I we demonstrated that homologous vaccination with human Her2/neu-VLPs was more efficient against outgrowth of human Her2/neu-expressing tumors than heterologous vaccination with rat Her2/neu-VLPs, while against rat Her2/neu-tumors, rat Her2/neu-VLPs were more efficient. Furthermore, we observed that vaccination with MPtVLPs was more efficient than vaccination with MPyVLPs, and that Her2MPtVLPs could be used for therapeutic vaccination. In paper II we demonstrated that both CD4+ and CD8+T cells are involved in the tumor protective response after Her2MPtVLP vaccination. In paper III immunization with PSA-MPyVLPs, given together with CpG and loaded onto dendritic cells, was shown to protect against outgrowth of PSA-expressing tumor cells. In paper IV RHCC was shown to incorporate cisplatin, and the complex entered human tumor cells, while retaining the cytotoxic potential of the drug both in vitro and in vivo. In conclusion, in this thesis it is shown that VLPs based on MPyV and MPtV were efficient vectors for tumor antigens in cancer vaccination, evoking both CD4+ and CD8+ cell responses. In addition, we show that RHCC can function as a carrier for cisplatin, and that it could potentially reduce some of the negative side effects with cisplatin treatment
3.
  • Eriksson, Mathilda, 1984- (författare)
  • Mitigating climate change with forest climate tools
  • 2016
  • Rapport (övrigt vetenskapligt)abstract
    • <p>This paper develops the FRICE, a framework that determines optimal levels of forest climate tools in the context of global climate policy. The paper integrates afforestation and avoided deforestation into the well-known global multi-regional integrated assessment model, RICE-2010. The paper finds that climate forest tools can play an essential role in global climate policy and that this role is increasingly important under stringent temperature targets. Under a 2_C temperature target, the model reveals that emission reductions from avoided deforestation are quickly exhausted whereas afforestation is capable of substantially reducing emission reductions in both the medium and long run. The model also indicates that the most significant reductions in emissions from avoided deforestation and afforestation can be achieved by focusing policy efforts on tropical forests.</p>
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4.
  • Eriksson, Mathilda, 1984-, et al. (författare)
  • Pricing forest carbon : implications of asymmetry in climate policy
  • 2016
  • Rapport (övrigt vetenskapligt)abstract
    • <p>In this paper, we use an integrated assessment model to examine the implications of not recognizing, and partially recognizing forest carbon in climate policy. Specifically, we investigate the impact of an asymmetric carbon policy that recognizes emissions from fossil fuels while ignoring emissions from forests. We additionally investigate the relative importance of not recognizing positive emissions from a reduction in the stock of forest biomass, or of not recognizing negative emissions from the growth of forest biomass. We show that asymmetric carbon policies lead to lower levels of welfare, as well as higher emissions and carbon prices. This occurs because the forest resource will be allocated inefficiently under these carbon policies. Broadly, we find that when the social planner does not account for neither positive or negative forest emissions, the planner will set bioenergy levels that are too high and afforestation and avoided deforestation levels that are too low. Our results further reveal that not recognizing forest emissions leads to larger welfare losses than not recognizing sequestration.</p>
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5.
  • Eriksson, Mathilda, et al. (författare)
  • Pricing forest carbon : implications of asymmetry in climate policy
  • 2018
  • Ingår i: Journal of Forest Economics. - Elsevier. - 1104-6899 .- 1618-1530. ; 32, s. 84-93
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Using an integrated assessment model, we examine the implications of climate policies that do not fully recognize forest carbon. Specifically, we first investigate the impact of an asymmetric policy that recognizes carbon emissions from fossil fuels while fully ignoring forest carbon. Next, we investigate the relative importance of not recognizing emissions from a reduction in the stock of forest biomass compared to not recognizing sequestration from the growth of forest biomass. We show that asymmetric carbon policies lead to lower levels of welfare, as well as higher emissions and carbon prices. This occurs because the forest resource will be allocated inefficiently under these carbon policies. Broadly, we find that when the social planner does not account for emissions or sequestration from the forest, the planner will set bioenergy levels that are too high and afforestation and avoided deforestation levels that are too low. Our results further reveal that not recognizing forest emissions leads to larger welfare losses than not recognizing sequestration.</p>
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6.
  • Eriksson, Mathilda (författare)
  • The role of the forest in an integrated assessment model of the climate and the economy
  • 2015
  • Ingår i: Climate Change Economics. - World Scientific. - 2010-0078 .- 2010-0086. ; 6:3
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>This paper develops the FOR-DICE model to explore the potential role of the global forest in reducing climate change. It presents a basic framework for assessing the boreal, tropical, and temperate forests as both a source of renewable energy and a resource to sequester and store carbon. The focus of the paper is to explore whether climate policies should focus on increasing the forest biomass, to sequester and store carbon, or on increasing the use of the forest biomass as a source of energy, to substitute fossil fuels. The paper shows that the global forest can play an important role in reducing atmospheric carbon. The main finding at the global level is that it is better to increase the forest biomass rather than increase the use of forest bioenergy. The reason for this is that the decrease in forest carbon stock created by increased bioenergy harvests is not offset by avoided fossil fuel emissions. This finding suggests that setting high bioenergy targets, without considering the dynamics of the forest stock and the efficiency of bioenergy, will be detrimental to climate change mitigation.</p>
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7.
  • Eriksson, Mathilda, 1984- (författare)
  • The Role of the Forest in Climate Policy
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • <p><strong>Abstract</strong><strong></strong></p><p>In <strong>Paper [I]</strong>, I develop the FOR-DICE model to analyze optimal global forest carbon management. The FOR-DICE is a simple framework for assessing the role of the boreal, tropical, and temperate forests as both a source of renewable energy and a resource to sequester and store carbon. I find that forests play an important role in reducing global emissions, especially under ambitious climate targets. At the global level, efforts should focus on increasing the stock of forest biomass rather than increasing the use of the forest for bioenergy production. The results also highlight the important role of reducing tropical deforestation to reduce climate change.</p><p>In <strong>Paper [II]</strong>, I develop the FRICE to investigate the role of two key efforts to increase the stock of forest biomass, namely, afforestation and avoided deforestation. FRICE is a multi-regional integrated assessment model that captures the dynamics of forest carbon sequestration in a transparent way and allows me to investigate the allocation of these actions across space and time. I find that global climate policy can benefit considerably from afforestation and avoided deforestation in tropical regions, and in particular in Africa. Avoided deforestation is particularly effective in the short run while afforestation provides the largest emissions reductions in the medium run. This paper also highlights the importance of not solely relying on avoided deforestation as its capacity to reduce emissions is more limited than afforestation, especially under more stringent temperature targets.</p><p>In <strong>Paper [III]</strong>, we investigate how uncertainties linked to the forest affect the optimal climate policy. We incorporate parameter uncertainty on the intrinsic growth rate and climate effects on the forest by using the state-contingent approach. Our results show that forest uncertainty matters. We find that the importance of including forest in climate policy increases when the forest is subject to uncertainty. This occurs because optimal forest response allows us to reduce the costs associated with uncertainty.</p><p>In <strong>Paper [IV]</strong>, we explore the implications of asymmetries in climate policy arising from not recognizing forest carbon emissions and sequestration in the decision-making process. We show that not fully including carbon values associated with the forest will have large effects on different forest controls and lead to an increase in emissions, higher carbon prices, and lower welfare.  We further find, by investigating the relative importance of forest emissions compared to sequestration, that recognizing forest emissions from bioenergy and deforestation is especially important for climate policy.</p>
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8.
  • Eriksson, Mathilda, et al. (författare)
  • Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin
  • 2009
  • Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 29:1, s. 11-18
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>BACKGROUND:</strong></p> <p>The nano-sized right-handed coiled-coil (RHCC) protein, originating from the archaebacterium Staphylothermus marinus, is stable at high salt concentrations, high temperatures, high pressures and extremes of pH. Its crystal structure reveals four hydrophobic cavities which can incorporate heavy metals. Nano-sized compounds have been used to carry cytotoxic drugs to tumours, avoiding delivery to healthy tissue, in part due to enhanced permeability in tumour blood vessels (enhanced permeability and retention effect).</p> <p><strong>MATERIALS AND METHODS:</strong></p> <p>The ability of RHCC to carry the platinum-containing chemotherapeutic drug cisplatin to cells, while retaining the cytotoxic potential was tested both in vitro and in vivo.</p> <p><strong>RESULTS:</strong></p> <p>RHCC was able to bind and enter cells in vitro and was not severely toxic or immunogenic in mice. Moreover, RHCC incorporated cisplatin, without inhibiting the cytotoxic potential of the drug against tumour cell lines in vitro or in vivo.</p> <p><strong>CONCLUSION:</strong></p> <p>RHCC can be used as a carrier of cisplatin without abrogating the effect of the drug.</p>
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9.
  • Eriksson, Mathilda, 1984-, et al. (författare)
  • When not in the best of worlds : uncertainty and forest carbon sequestration
  • 2016
  • Rapport (övrigt vetenskapligt)abstract
    • <p>It is argued that the forest can provide low-cost options to reduce the atmospheric CO2 concentration. However, many dimensions of the future dynamics of the forest, and its interactions with climate change are still not well understood. This paper provides new insights into how these types of uncertainties affect the optimal climate policy. We model uncertainty over several key forest parameters by using the novel state-contingent approach. Our main results show that the importance of including optimal forest controls in climate policy increases when the dynamics of the forest are uncertain. Ignoring uncertainties concerning the forest will lead to biased estimates of the social costs of carbon and be misleading when evaluating climate policies. Conversely, recognizing forest uncertainties and its potential to mitigate climate change will lead to a robust policy where the cost of uncertainty to a large extent can be avoided.</p>
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10.
  • Karlsson, Camilla, 1977-, et al. (författare)
  • Human embryonic stem cell-derived mesenchymal progenitors-Potential in regenerative medicine.
  • 2009
  • Ingår i: Stem cell research. - 1876-7753. ; 3:1, s. 39-50
  • Tidskriftsartikel (refereegranskat)abstract
    • Tissue engineering and cell therapy require large-scale production of homogeneous populations of lineage-restricted progenitor cells that easily can be induced to differentiate into a specific tissue. We have developed straightforward protocols for the establishment of human embryonic stem (hES) cell-derived mesenchymal progenitor (hES-MP) cell lines. The reproducibility was proven by derivation of multiple hES-MP cell lines from 10 different hES cell lines. To illustrate clinical applicability, a xeno-free hES-MP cell line was also derived. None of the markers characteristic for undifferentiated hES cells were detected in the hES-MP cells. Instead, these cells were highly similar to mesenchymal stem cells with regard to morphology and expression of markers. The safety of hES-MP cells following transplantation was studied in severely combined immunodeficient (SCID) mice. The implanted hES-MP cells gave rise to homogeneous, well-differentiated tissues exclusively of mesenchymal origin and no teratoma formation was observed. These cells further have the potential to differentiate toward the osteogenic, adipogenic, and chondrogenic lineages in vitro. The possibility of easily and reproducibly generating highly expandable hES-MP cell lines from well-characterized hES cell lines with differentiation potential into several mesodermal tissues entails an enormous potential for the field of regenerative medicine.
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