| 1. |
- Chirumalla, Koteshwar, et al.
(author)
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The influence of different media instructions on solving a procedural task
- 2015
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In: ICED 15, Vol. 11. - 9781904670742
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Conference paper (peer-reviewed)abstract
- This study investigates the influence of different forms of media instructions on the process and outcomes of completing a specific procedural task. The experiment was conducted with four student groups having an education in the area of Information Design. In the experiment four media instructions - text only, text plus drawings, a series of pictures and video with narration - were considered. The findings show that the type of media has an influence on the ability to solve a procedural task and on group interaction and the way groups solve a task. Compared with the other instructions, video instruction triggered a different interaction and behavioural pattern during assembly. Participants considered both video and picture instructions as more usable in terms of facilitating the ability to understand, select and apply possible solutions to a given task. However, the video medium showed little influence on dialogue in the group during assembly. The instructions, such as text plus drawings, pictures and video had a similar influence on task performance times, whereas text instructions took three times longer to implement than other instructions.
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| 2. |
- Huang, Yezi, et al.
(author)
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Enabling DSL and Radio on the Same Copper Pair
- 2015
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In: 2015 IEEE International Conference on Communications (ICC). - 9781467364324 ; , s. 1031-1035
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Conference paper (peer-reviewed)abstract
- To increase indoor coverage for mobile services, we propose a residential small cell infrastructure making use of the existing copper plant. The system is cabinet-based, collocated with VDSL2 and uses small pieces of spectrum next to VDSL2. Inspired by the Ericsson Radio Dot System, it challenges the femtocell paradigm offering full macro functionality in the small cells. An interesting service potential is offered albeit the added mobile traffic capacity is moderate as it is limited by the copper fronthaul.
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| 3. |
- Huang, Yezi, et al.
(author)
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LTE Over Copper - Potential and Limitations
- 2015
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In: 2015 IEEE 26th Annual International Symposium on Personal, Indoor, and Mobile Radio Communications (PIMRC). - 9781467367820 ; , s. 1339-1343
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Conference paper (peer-reviewed)abstract
- The densification of mobile networks in order to meet increased capacity demands is ongoing, needed and costly. A few papers have been published based on the insight that the fixed broadband networks offer a multitude of sites, for instance our homes, for potential small cell deployment providing backhaul capacity and power without site costs. However, in order to reach economical large-scale benefits, we explore the case when radio systems are deployed in coexistence with DSL. In this paper, we establish the feasibility of such a concept under constraints invoked by state-of-the-art and emerging systems (3GPP, VDSL2 and G.fast) and make statements about the required architecture. We also point out that the enthusiasm of previously published results should be lowered a notch.
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| 4. |
- Huang, Yezi, et al.
(author)
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Time-Domain Precoding for LTE-over-Copper Systems
- 2016
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In: 2016 IEEE International Conference on Communications (ICC). - 9781479966646 - 9781479966653 ; , s. 1-6
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Conference paper (peer-reviewed)abstract
- Crosstalk cancellation is a crucial issue for traditional digital subscriber line systems. For LTE-over-copper systems, however, the need for crosstalk cancellation varies depending on the analog fronthauling architecture and its parameters. A crosstalk handler that is decoupled as much as possible from the rest of the system architecture is thus preferred. Therefore, we propose a time-domain precoding scheme specifically in downstream direction to separate the precoding unit from the LTE signal flow, and perform crosstalk cancellation in an on-demand manner. Estimation of all direct and crosstalk paths is assisted by LTE cell-specific reference signals. The time-domain precoder transforms the interference channel into a crosstalk-free channel with identical direct paths, which allows for low-complexity inter-symbol interference mitigation. We evaluate the concept in terms of signal-to-noise ratio provided for LTE signals using measured wireline channel data.
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| 5. |
- Locke, Adam E, et al.
(author)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Journal article (peer-reviewed)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 6. |
- Medeiros, Eduardo, et al.
(author)
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Crosstalk Mitigation for LTE-over-Copper in Downlink Direction
- 2016
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In: IEEE Communications Letters. - 1089-7798. ; 20:7, s. 1425-1428
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Journal article (peer-reviewed)abstract
- Radio-over-copper is a niche idea that has potential to become a cornerstone in the deployment of dense 5G networks. We address one of the remaining hurdles and present an architecture for transparent crosstalk mitigation in LTE-over-copper systems. By taking advantage of reference symbols present in the downlink LTE signals we propose two methods for estimating the copper channel. System performance is evaluated using channel measurements and error vector magnitude calculations with promising results.
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| 7. |
- Aldenlöv, Jens
(author)
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Exploring Public Procurement of Swedish Railway Infrastructure Maintenance
- 2019
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Licentiate thesis (other academic/artistic)abstract
- In 2002, Sweden started to outsource its railway infrastructure maintenance. Through gradual exposure (i.e. outsourcing one contract area at a time), the Swedish Transport Administration has developed its competence of being a client towards its contractors. The last contract was outsourced in 2014. In the last decade, the development of governance techniques and maintenance cost has not matched the increase in traffic. Due to an increased awareness in environmentally friendlier transportation, traffic is only expected to increase further in the coming years. Governance techniques and maintenance cost ultimately depends on the client-contractor relationship through public procurement. Hence, there is a need to understand public procurement of railway infrastructure maintenance. Therefore, the purpose of this thesis is to contribute to the knowledge of public procurement of railway infrastructure maintenance. Three separate studies were conducted. Study 1 was a literature review to explore and determine the state-of-the-art for the field of public procurement of railway maintenance. Study 2 was a linear regression analysis to examine the relationship between contract design and the output of maintenance in Sweden. Study 3 was an interview study in Sweden that explored what factors that supports or hinders collaboration in railway maintenance.The main results of these studies are that asset knowledge is important for both the client and the contractor. Through reliable asset knowledge, incentives and contracts can be designed to support governance and collaboration. Today, railway infrastructure maintenance is dominated by informal relationships that lack the support of formal partnering activities. When an informal relationship is supported by a formal structure it provides a basis for innovation. This formal structure should be centralized around gaining and sharing asset knowledge. By establishing such a system to increase the asset knowledge and supporting collaboration, public organizations of maintenance can provide a basis for the improvement of maintenance.
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| 8. |
- Brechmann, Nils Arnold, et al.
(author)
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Pilot-scale process for magnetic bead purification of antibodies directly from non-clarified CHO cell culture
- 2019
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In: Biotechnology progress (Print). - : AIChE. - 8756-7938 .- 1520-6033.
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Journal article (peer-reviewed)abstract
- High capacity magnetic protein A agarose beads, LOABeads PrtA, were used in the developmentof a new process for affinity purification of monoclonal antibodies (mAbs) from non-clarifiedCHO cell broth using a pilot-scale magnetic separator. The LOABeads had a maximum bindingcapacity of 65 mg/mL and an adsorption capacity of 25–42 mg IgG/mL bead in suspension for anIgG concentration of 1 to 8 g/L. Pilot-scale separation was initially tested in a mAb capture stepfrom 26 L clarified harvest. Small-scale experiments showed that similar mAb adsorptions wereobtained in cell broth containing 40 Å~ 106 cells/mL as in clarified supernatant. Two pilot-scalepurification runs were then performed on non-clarified cell broth from fed-batch runs of 16 L,where a rapid mAb adsorption ≥96.6% was observed after 1 h. This process using 1 L of magnetic beads had an overall mAb yield of 86% and 16 times concentration factor. After this single proteinA capture step, the mAb purity was similar to the one obtained by column chromatography, whilethe host cell protein content was very low, <10 ppm. Our results showed that this magnetic beadmAb purification process, using a dedicated pilot-scale separation device, was a highly efficientsingle step, which directly connected the culture to the downstream process without cell clarification.Purification of mAb directly from non-clarified cell broth without cell separation can providesignificant savings in terms of resources, operation time, and equipment, compared to legacy procedure of cell separation followed by column chromatography step.
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| 9. |
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| 10. |
- Ekstrom, Mattias, et al.
(author)
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Stimulated in vivo synthesis of plasminogen activator inhibitor 1 in human adipose tissue
- 2012
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In: Thrombosis and Haemostasis. - 0340-6245 .- 2567-689X. ; 108:3, s. 485-492
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Journal article (peer-reviewed)abstract
- Plasminogen activator inhibitor type-1 (PAI-1) is one of the most important inhibitors of endogenous fibrinolysis. Adipose tissue is a suggested source of the elevated plasma levels o(-) PAI-1 in obesity. The relation between PAI-1 and inflammation is of particular interest, but current knowledge regarding regulation of PAI-1 in adipose tissue is mainly based on animal studies or ex vivo experiments on human cultured adipocytes. So far, no study has described stimulated gene expression and protein synthesis of PAI-1 in vivo in human adipose tissue. We used open heart surgery as a model of acute systemic inflammation. Twenty-two male patients underwent blood sampling and omental and subcutaneous adipose tissue biopsies for gene expression studies before and after surgery. Expression and localisation of PAI-1 antigen was evaluated by immunohistochemistry. After surgery gene expression of PAI-1 increased 27-fold in omental adipose tissue and three-fold in subcutaneous adipose tissue, but no differences were found in tissue-type plasminogen activator (t-PA) mRNA. PAI-1 antigen was localised within endothelial cells and in the adipose tissue interstitium close to vessels. The upregulated gene expression and protein synthesis in adipose tissue was followed by increased concentrations of PAI-1 antigen in plasma. In conclusion, we present for the first time that an acute systemic inflammation in humans increased gene expression and protein synthesis of PAI-1 in adipose tissue and that this increase was most prominent in omental adipose tissue. PAI-1 synthesis in adipose tissue due to acute systemic inflammation may be a link between inflammation and impaired endogenous fibrinolysis.
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