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Patterns and dietar...
Patterns and dietary determinants of essential and toxic elements in blood measured in mid-pregnancy : The Norwegian Environmental Biobank
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- Caspersen, Ida Henriette (författare)
- Norwegian Institute of Public Health
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- Thomsen, Cathrine (författare)
- Norwegian Institute of Public Health
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- Haug, Line Småstuen (författare)
- Norwegian Institute of Public Health
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- Knutsen, Helle K. (författare)
- Norwegian Institute of Public Health
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- Brantsæter, Anne Lise (författare)
- Norwegian Institute of Public Health
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- Papadopoulou, Eleni (författare)
- Norwegian Institute of Public Health
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- Erlund, Iris (författare)
- Finnish National Institute for Health and Welfare
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- Lundh, Thomas (författare)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Alexander, Jan (författare)
- Norwegian Institute of Public Health
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- Meltzer, Helle Margrete (författare)
- Norwegian Institute of Public Health
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska 10 s.
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 671, s. 299-308
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Inadequate stores or intakes of essential minerals in pregnancy, or too high exposure to both toxic and essential elements, can have adverse effects on mother and child. The main aims of this study were to 1) describe the concentrations and patterns of essential and toxic elements measured in maternal whole blood during pregnancy; 2) identify dietary, lifestyle and sociodemographic determinants of element status; and 3) explore the impact of iron deficiency on blood element concentrations. Methods: This study is based on blood samples collected from 2982 women in gestational week 18 in The Norwegian Mother and Child Cohort study (MoBa) which were analyzed as part of the Norwegian Environmental Biobank. We derived blood element patterns by exploratory factor analysis, and associations between blood element patterns and diet were explored using sparse partial least squares (sPLS) regression. Results: Blood concentrations were determined for the essential elements (in the order of most abundant) Zn > Cu > Se > Mn > Mo > Co, and the toxic metals Pb > As > Hg > Cd > Tl. The concentrations were in ranges that were similar to or sometimes more favorable than in other pregnant and non-pregnant European women. We identified two blood element patterns; one including Zn, Se and Mn and another including Hg and As. For the Zn-Se-Mn pattern, use of multimineral supplements was the most important dietary determinant, while a high score in the Hg-As pattern was mainly determined by seafood consumption. Concentrations of Mn, Cd and Co were significantly higher in women with iron deficiency (plasma ferritin < 12 μg/L) than in women with plasma ferritin ≥ 12 μg/L. Conclusion: Our study illustrates complex relationships and coexistence of essential and toxic elements. Their potential interplay adds to the challenges of studies investigating health effects related to either diet or toxicants.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Dietary exposure
- Essential nutrients
- Heavy metals
- Iron deficiency
- MoBa
- The Norwegian Mother and Child Cohort Study
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- art (ämneskategori)
- ref (ämneskategori)
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Caspersen, Ida H ...
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Thomsen, Cathrin ...
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Haug, Line Småst ...
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Knutsen, Helle K ...
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Brantsæter, Anne ...
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Papadopoulou, El ...
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Erlund, Iris
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Lundh, Thomas
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Alexander, Jan
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Meltzer, Helle M ...
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