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Genome-wide association study identifies eight loci associated with blood pressure

Newton-Cheh, Christopher (author)
Johnson, Toby (author)
Gateva, Vesela (author)
show more...
Tobin, Martin D. (author)
Bochud, Murielle (author)
Coin, Lachlan (author)
Najjar, Samer S. (author)
Zhao, Jing Hua (author)
Heath, Simon C. (author)
Eyheramendy, Susana (author)
Papadakis, Konstantinos (author)
Voight, Benjamin F. (author)
Scott, Laura J. (author)
Zhang, Feng (author)
Farrall, Martin (author)
Tanaka, Toshiko (author)
Wallace, Chris (author)
Chambers, John C. (author)
Khaw, Kay-Tee (author)
Nilsson, Peter (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
van der Harst, Pim (author)
Polidoro, Silvia (author)
Grobbee, Diederick E. (author)
Onland-Moret, N. Charlotte (author)
Bots, Michiel L. (author)
Wain, Louise V. (author)
Elliott, Katherine S. (author)
Teumer, Alexander (author)
Luan, Jian'an (author)
Lucas, Gavin (author)
Kuusisto, Johanna (author)
Burton, Paul R. (author)
Hadley, David (author)
McArdle, Wendy L. (author)
Brown, Morris (author)
Dominiczak, Anna (author)
Newhouse, Stephen J. (author)
Samani, Nilesh J. (author)
Webster, John (author)
Zeggini, Eleftheria (author)
Beckmann, Jacques S. (author)
Bergmann, Sven (author)
Lim, Noha (author)
Song, Kijoung (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Waterworth, Dawn M. (author)
Yuan, Xin (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Orho-Melander, Marju (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Allione, Alessandra (author)
Karolinska Institutet
Di Gregorio, Alessandra (author)
Guarrera, Simonetta (author)
Panico, Salvatore (author)
Ricceri, Fulvio (author)
Romanazzi, Valeria (author)
Sacerdote, Carlotta (author)
Vineis, Paolo (author)
Barroso, Ines (author)
Sandhu, Manjinder S. (author)
Luben, Robert N. (author)
Crawford, Gabriel J. (author)
Jousilahti, Pekka (author)
Perola, Markus (author)
Boehnke, Michael (author)
Bonnycastle, Lori L. (author)
Collins, Francis S. (author)
Jackson, Anne U. (author)
Mohlke, Karen L. (author)
Stringham, Heather M. (author)
Valle, Timo T. (author)
Willer, Cristen J. (author)
Bergman, Richard N. (author)
Morken, Mario A. (author)
Doering, Angela (author)
Gieger, Christian (author)
Illig, Thomas (author)
Meitinger, Thomas (author)
Org, Elin (author)
Pfeufer, Arne (author)
Wichmann, H. Erich (author)
Kathiresan, Sekar (author)
Marrugat, Jaume (author)
O'Donnell, Christopher J. (author)
Schwartz, Stephen M. (author)
Siscovick, David S. (author)
Subirana, Isaac (author)
Freimer, Nelson B. (author)
Hartikainen, Anna-Liisa (author)
McCarthy, Mark I. (author)
O'Reilly, Paul F. (author)
Peltonen, Leena (author)
Pouta, Anneli (author)
de Jong, Paul E. (author)
Snieder, Harold (author)
van Gilst, Wiek H. (author)
Clarke, Robert (author)
Goel, Anuj (author)
Hamsten, Anders (author)
Peden, John F. (author)
Seedorf, Udo (author)
Syvänen, Ann-Christine (author)
Uppsala universitet,Molekylär medicin
Tognoni, Giovanni (author)
Lakatta, Edward G. (author)
Sanna, Serena (author)
Scheet, Paul (author)
Schlessinger, David (author)
Scuteri, Angelo (author)
Doerr, Marcus (author)
Ernst, Florian (author)
Felix, Stephan B. (author)
Homuth, Georg (author)
Lorbeer, Roberto (author)
Reffelmann, Thorsten (author)
Rettig, Rainer (author)
Voelker, Uwe (author)
Galan, Pilar (author)
Gut, Ivo G. (author)
Hercberg, Serge (author)
Lathrop, G. Mark (author)
Zelenika, Diana (author)
Deloukas, Panos (author)
Soranzo, Nicole (author)
Williams, Frances M. (author)
Zhai, Guangju (author)
Salomaa, Veikko (author)
Laakso, Markku (author)
Elosua, Roberto (author)
Forouhi, Nita G. (author)
Volzke, Henry (author)
Uiterwaal, Cuno S. (author)
van der Schouw, Yvonne T. (author)
Numans, Mattijs E. (author)
Matullo, Giuseppe (author)
Navis, Gerjan (author)
Berglund, Göran (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Bingham, Sheila A. (author)
Kooner, Jaspal S. (author)
Connell, John M. (author)
Bandinelli, Stefania (author)
Ferrucci, Luigi (author)
Watkins, Hugh (author)
Spector, Tim D. (author)
Tuomilehto, Jaakko (author)
Altshuler, David (author)
Strachan, David P. (author)
Laan, Maris (author)
Meneton, Pierre (author)
Wareham, Nicholas J. (author)
Uda, Manuela (author)
Jarvelin, Marjo-Riitta (author)
Mooser, Vincent (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Loos, Ruth J. F. (author)
Elliott, Paul (author)
Abecasis, Goncalo R. (author)
Caulfield, Mark (author)
Munroe, Patricia B. (author)
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 (creator_code:org_t)
2009-05-10
2009
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:6, s. 666-676
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

MEDICINE

Publication and Content Type

art (subject category)
ref (subject category)

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By the author/editor
Newton-Cheh, Chr ...
Johnson, Toby
Gateva, Vesela
Tobin, Martin D.
Bochud, Murielle
Coin, Lachlan
show more...
Najjar, Samer S.
Zhao, Jing Hua
Heath, Simon C.
Eyheramendy, Sus ...
Papadakis, Konst ...
Voight, Benjamin ...
Scott, Laura J.
Zhang, Feng
Farrall, Martin
Tanaka, Toshiko
Wallace, Chris
Chambers, John C ...
Khaw, Kay-Tee
Nilsson, Peter
van der Harst, P ...
Polidoro, Silvia
Grobbee, Diederi ...
Onland-Moret, N. ...
Bots, Michiel L.
Wain, Louise V.
Elliott, Katheri ...
Teumer, Alexande ...
Luan, Jian'an
Lucas, Gavin
Kuusisto, Johann ...
Burton, Paul R.
Hadley, David
McArdle, Wendy L ...
Brown, Morris
Dominiczak, Anna
Newhouse, Stephe ...
Samani, Nilesh J ...
Webster, John
Zeggini, Elefthe ...
Beckmann, Jacque ...
Bergmann, Sven
Lim, Noha
Song, Kijoung
Vollenweider, Pe ...
Waeber, Gerard
Waterworth, Dawn ...
Yuan, Xin
Groop, Leif
Orho-Melander, M ...
Allione, Alessan ...
Di Gregorio, Ale ...
Guarrera, Simone ...
Panico, Salvator ...
Ricceri, Fulvio
Romanazzi, Valer ...
Sacerdote, Carlo ...
Vineis, Paolo
Barroso, Ines
Sandhu, Manjinde ...
Luben, Robert N.
Crawford, Gabrie ...
Jousilahti, Pekk ...
Perola, Markus
Boehnke, Michael
Bonnycastle, Lor ...
Collins, Francis ...
Jackson, Anne U.
Mohlke, Karen L.
Stringham, Heath ...
Valle, Timo T.
Willer, Cristen ...
Bergman, Richard ...
Morken, Mario A.
Doering, Angela
Gieger, Christia ...
Illig, Thomas
Meitinger, Thoma ...
Org, Elin
Pfeufer, Arne
Wichmann, H. Eri ...
Kathiresan, Seka ...
Marrugat, Jaume
O'Donnell, Chris ...
Schwartz, Stephe ...
Siscovick, David ...
Subirana, Isaac
Freimer, Nelson ...
Hartikainen, Ann ...
McCarthy, Mark I ...
O'Reilly, Paul F ...
Peltonen, Leena
Pouta, Anneli
de Jong, Paul E.
Snieder, Harold
van Gilst, Wiek ...
Clarke, Robert
Goel, Anuj
Hamsten, Anders
Peden, John F.
Seedorf, Udo
Syvänen, Ann-Chr ...
Tognoni, Giovann ...
Lakatta, Edward ...
Sanna, Serena
Scheet, Paul
Schlessinger, Da ...
Scuteri, Angelo
Doerr, Marcus
Ernst, Florian
Felix, Stephan B ...
Homuth, Georg
Lorbeer, Roberto
Reffelmann, Thor ...
Rettig, Rainer
Voelker, Uwe
Galan, Pilar
Gut, Ivo G.
Hercberg, Serge
Lathrop, G. Mark
Zelenika, Diana
Deloukas, Panos
Soranzo, Nicole
Williams, France ...
Zhai, Guangju
Salomaa, Veikko
Laakso, Markku
Elosua, Roberto
Forouhi, Nita G.
Volzke, Henry
Uiterwaal, Cuno ...
van der Schouw, ...
Numans, Mattijs ...
Matullo, Giusepp ...
Navis, Gerjan
Berglund, Göran
Bingham, Sheila ...
Kooner, Jaspal S ...
Connell, John M.
Bandinelli, Stef ...
Ferrucci, Luigi
Watkins, Hugh
Spector, Tim D.
Tuomilehto, Jaak ...
Altshuler, David
Strachan, David ...
Laan, Maris
Meneton, Pierre
Wareham, Nichola ...
Uda, Manuela
Jarvelin, Marjo- ...
Mooser, Vincent
Melander, Olle
Loos, Ruth J. F.
Elliott, Paul
Abecasis, Goncal ...
Caulfield, Mark
Munroe, Patricia ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Other Clinical M ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature Genetics
By the university
Lund University
Karolinska Institutet
Uppsala University

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