SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Esko Tõnu) ;conttype:(scientificother)"

Sökning: WFRF:(Esko Tõnu) > Övrigt vetenskapligt/konstnärligt

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Khalili, Bita, et al. (författare)
  • Associations between common genetic variants and income provide insights about the socioeconomic health gradient
  • 2024
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes. Our GWAS-derived polygenic index captures 1 - 4% of income variance, with only one-fourth attributed to direct genetic effects. A phenome-wide association study using this polygenic index showed reduced risks for a broad spectrum of diseases, including hypertension, obesity, type 2 diabetes, coronary atherosclerosis, depression, asthma, and back pain. The income factor showed a substantial genetic correlation (0.92, s.e. = .006) with educational attainment (EA). Accounting for EA's genetic overlap with income revealed that the remaining genetic signal for higher income related to better mental health but reduced physical health benefits and increased participation in risky behaviours such as drinking and smoking.
  •  
2.
  • Klaric, Lucija, et al. (författare)
  • Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.
  • 2021
  • Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory. ; , s. 1-28
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19. Using protein quantitative trait loci (pQTL) data from the SCALLOP consortium, involving meta-analysis of up to 26,494 individuals, and COVID-19 genome-wide association data from the Host Genetics Initiative, we performed MR for 157 COVID-19 severity protein biomarkers. We identified significant MR results for five proteins: FAS, TNFRSF10A, CCL2, EPHB4 and LGALS9. Further evaluation of these candidates using sensitivity analyses and colocalization testing provided strong evidence to implicate the apoptosis-associated cytokine receptor FAS as a causal mediator of severe COVID-19. This effect was specific to severe disease. Using RNA-seq data from 4,778 individuals, we demonstrate that the pQTL at the FAS locus results from genetically influenced alternate splicing causing skipping of exon 6. We show that the risk allele for very severe COVID-19 increases the proportion of transcripts lacking exon 6, and thereby increases soluble FAS. Soluble FAS acts as a decoy receptor for FAS-ligand, inhibiting apoptosis induced through membrane-bound FAS. In summary, we demonstrate a novel genetic mechanism that contributes to risk of severe of COVID-19, highlighting a pathway that may be a promising therapeutic target.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
annan publikation (2)
Typ av innehåll
övrigt vetenskapligt/konstnärligt  (2)Ta bort avgränsningen
Författare/redaktör
Boomsma, D (1)
Gyllensten, Ulf B. (1)
Landén, Mikael, 1966 (1)
Magnus, Per (1)
Magnusson, Martin (1)
Lind, Lars (1)
visa fler...
Smith, J Gustav (1)
Benjamin, Daniel (1)
Johannesson, Magnus (1)
Campbell, Harry (1)
Chen, Yan (1)
Wareham, Nicholas J. (1)
Suhre, Karsten (1)
Hansson, Oskar (1)
Ahlskog, Rafael (1)
Koellinger, Philipp ... (1)
Oskarsson, Sven (1)
Eriksson, Per (1)
Mattsson-Carlgren, N ... (1)
Ikram, M. Arfan (1)
Langenberg, Claudia (1)
Lee, James J. (1)
Enroth, Stefan, 1976 ... (1)
Johansson, Åsa (1)
Wallentin, Lars, 194 ... (1)
Willemsen, Gonneke (1)
Gieger, Christian (1)
Martin, Nicholas G. (1)
Kaprio, Jaakko (1)
Padyukov, Leonid (1)
Folkersen, Lasse (1)
Walker, Mark (1)
Hedman, Åsa K (1)
Michaëlsson, Karl, 1 ... (1)
Gustafsson, Stefan (1)
Gigante, Bruna (1)
Siegbahn, Agneta, 19 ... (1)
Wilson, James F. (1)
Kooperberg, Charles (1)
Bhatta, Laxmi (1)
Beauchamp, Jonathan (1)
Thorand, Barbara (1)
Zhao, Jing Hua (1)
Homuth, Georg (1)
Völzke, Henry (1)
Hayward, Caroline (1)
Polasek, Ozren (1)
Hwang, Shih-Jen (1)
van der Most, Peter ... (1)
Assimes, Themistocle ... (1)
visa färre...
Lärosäte
Göteborgs universitet (1)
Uppsala universitet (1)
Lunds universitet (1)
Handelshögskolan i Stockholm (1)
Karolinska Institutet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy