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- Coustenis, A., et al.
(författare)
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TandEM : Titan and Enceladus mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 893-946
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Tidskriftsartikel (refereegranskat)abstract
- TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (MontgolfiSre) and possibly several landing probes to be delivered through the atmosphere.
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- Brownstein, Catherine A., et al.
(författare)
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An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge
- 2014
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 15:3, s. R53-
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing genetic disease starting from clinical case history and genome sequencing data. DNA samples were obtained from three families with heritable genetic disorders and genomic sequence data were donated by sequencing platform vendors. The challenge was to analyze and interpret these data with the goals of identifying disease-causing variants and reporting the findings in a clinically useful format. Participating contestant groups were solicited broadly, and an independent panel of judges evaluated their performance. Results: A total of 30 international groups were engaged. The entries reveal a general convergence of practices on most elements of the analysis and interpretation process. However, even given this commonality of approach, only two groups identified the consensus candidate variants in all disease cases, demonstrating a need for consistent fine-tuning of the generally accepted methods. There was greater diversity of the final clinical report content and in the patient consenting process, demonstrating that these areas require additional exploration and standardization. Conclusions: The CLARITY Challenge provides a comprehensive assessment of current practices for using genome sequencing to diagnose and report genetic diseases. There is remarkable convergence in bioinformatic techniques, but medical interpretation and reporting are areas that require further development by many groups.
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- Bodén, Hans, et al.
(författare)
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Noise from turbo-charged diesel engine exhaust systems
- 2005
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Ingår i: 12th International Congress on Sound and Vibration 2005. - 9781627481496 ; , s. 2231-2238
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Konferensbidrag (refereegranskat)abstract
- This paper summarises the main results of an EU-funded research project, ARTEMIS (G3RD-CT-2001-00511), on noise from turbo-charged Diesel engine exhaust systems. The project started in September 2001 and ended in August 2004 and was co-ordinated by KTH. The project had 10 partners from 6 different European countries, 5 universities and 5 companies including some major truck and car manufacturers. The main objective was to develop new and improved computational tools for predicting noise from exhaust systems. New models for describing the engine as an acoustic source were developed and experimentally tested. They include a linear time-varying source model and a non-linear frequency domain model. Linear time-invariant source data was also determined both from experiments and using 1-D gas-exchange simulations. New and improved models were developed for the turbo-group including non-linear time domain models and a linear time-varying model. New models were developed and experimentally tested for sound transmission through the Diesel particulate filter included in modern Diesel engine after-treatment devices. Improved models were developed for describing perforate mufflers with high mean flow velocities. Improved experimental techniques for determination of transmission properties of duct system components were developed. Models were developed and coded for sound reflection and radiation from tailpipe openings. Full experimental validation of the Munt theory for radiation from open pipes with flow was produced. In conclusion it can be said that the project was successful and gave many useful results.
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- Needleman, I, et al.
(författare)
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Nutrition and oral health in sport : time for action
- 2018
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 52:23, s. 1483-1484
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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