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Sökning: WFRF:(Fede E.)

  • Resultat 1-6 av 6
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1.
  • Acharya, B. S., et al. (författare)
  • Introducing the CTA concept
  • 2013
  • Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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4.
  • Iacopetta, B, et al. (författare)
  • Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
  • 2006
  • Ingår i: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. - : Elsevier BV. - 0923-7534. ; 17:5, s. 842-7
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified according to functional status for transactivation. RESULTS: Inactive TP53 mutations were found in 29% of all CRCs and were more frequent in rectal (32%) than proximal colon (22%) tumours (P < 0.001). Higher frequencies of inactive TP53 mutations were also seen in advanced stage tumours (P = 0.0003) and in tumours with the poor prognostic features of vascular (P = 0.006) and lymphatic invasion (P = 0.002). Inactive TP53 mutations were associated with significantly worse outcome only in patients with Dukes' stage D tumours (RR = 1.71, 95%CI 1.25-2.33, P < 0.001). Patients with Dukes' C stage tumours appeared to gain a survival benefit from 5-fluorouracil-based chemotherapy regardless of TP53 functional status for transactivation ability. CONCLUSIONS: Mutations that inactivate the transactivational ability of TP53 are more frequent in advanced CRC and are associated with worse prognosis in this stage of disease.
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5.
  • Brändle de Motta, J. C., et al. (författare)
  • Assessment of numerical methods for fully resolved simulations of particle-laden turbulent flows
  • 2019
  • Ingår i: Computers & Fluids. - : Elsevier Ltd. - 0045-7930 .- 1879-0747. ; 179, s. 1-14
  • Tidskriftsartikel (refereegranskat)abstract
    • During the last decade, many approaches for resolved-particle simulation (RPS) have been developed for numerical studies of finite-size particle-laden turbulent flows. In this paper, three RPS approaches are compared for a particle-laden decaying turbulence case. These methods are, the Volume-of-Fluid Lagrangian method, based on the viscosity penalty method (VoF-Lag); a direct forcing Immersed Boundary Method, based on a regularized delta function approach for the fluid/solid coupling (IBM); and the Bounce Back scheme developed for Lattice Boltzmann method (LBM-BB). The physics and the numerical performances of the methods are analyzed. Modulation of turbulence is observed for all the methods, with a faster decay of turbulent kinetic energy compared to the single-phase case. Lagrangian particle statistics, such as the velocity probability density function and the velocity autocorrelation function, show minor differences among the three methods. However, major differences between the codes are observed in the evolution of the particle kinetic energy. These differences are related to the treatment of the initial condition when the particles are inserted in an initially single-phase turbulence. The averaged particle/fluid slip velocity is also analyzed, showing similar behavior as compared to the results referred in the literature. The computational performances of the different methods differ significantly. The VoF-Lag method appears to be computationally most expensive. Indeed, this method is not adapted to turbulent cases. The IBM and LBM-BB implementations show very good scaling.
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6.
  • Cope, Jonathan E., et al. (författare)
  • Clear effects on root system architecture of winter wheat cultivars (Triticum aestivum L.) from cultivation environment and practices
  • 2024
  • Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Roots play a pivotal role in the adaption of a plant to its environment, with different root traits adapting the plant to different stresses. The environment affects the Root System Architecture (RSA), but the genetic factors determine to what extent, and whether stress brought about by extreme environmental conditions is detrimental to a specific crop. This study aimed to identify differences in winter wheat RSA caused by cultivation region and practice, in the form of preceding crop (precrop), and to identify if modern cultivars used in Sweden differ in their reaction to these environments. This was undertaken using high-throughput phenotyping to assess the RSA. Clear differences in the RSA were observed between the Swedish cultivation regions, precrop treatments, and interaction of these conditions with each other and the genetics. Julius showed a large difference between cultivars, with 9.3-17.1% fewer and 12-20% narrower seminal roots. Standardized yield decreased when grown after wheat, 23% less compared to oilseed rape (OSR), and when grown in the Southern region, 14% less than the Central region. Additionally, correlations were shown between the root number, angle, and grain yield, with different root types being correlated depending on the precrop. Cultivars on the Swedish market show differences that can be adapted to the region-precrop combinations. The differences in precrop effect on RSA between regions show global implications and a need for further assessment. Correlations between RSA and yield, based on root-typexprecrop, indicate different needs of the RSA depending on the management practices and show the potential for improving crop yield through targeting genotypic and environmental conditions in a holistic manner. Understanding this RSA variance, and the mechanisms of conditional response, will allow targeted cultivar breeding for specific environments, increasing plant health and food security.
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  • Resultat 1-6 av 6

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