| 1. |
- Lüscher, Bernhard, et al.
(författare)
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ADP-ribosyltransferases, an update on function and nomenclature
- 2022
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Ingår i: The FEBS Journal. - : John Wiley & Sons. - 1742-464X .- 1742-4658. ; 289:23, s. 7399-7410
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Tidskriftsartikel (refereegranskat)abstract
- ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- and extracellular signaling, chromatin and transcriptional regulation, protein biosynthesis, and cell death. ADP-ribosylation is catalyzed by ADP-ribosyltransferases (ARTs), which transfer ADP-ribose from NAD+ onto substrates. The modification, which occurs as mono- or poly-ADP-ribosylation, is reversible due to the action of different ADP-ribosylhydrolases. Importantly, inhibitors of ARTs are approved or are being developed for clinical use. Moreover, ADP-ribosylhydrolases are being assessed as therapeutic targets, foremost as antiviral drugs and for oncological indications. Due to the development of novel reagents and major technological advances that allow the study of ADP-ribosylation in unprecedented detail, an increasing number of cellular processes and pathways are being identified that are regulated by ADP-ribosylation. In addition, characterization of biochemical and structural aspects of the ARTs and their catalytic activities have expanded our understanding of this protein family. This increased knowledge requires that a common nomenclature be used to describe the relevant enzymes. Therefore, in this viewpoint, we propose an updated and broadly supported nomenclature for mammalian ARTs that will facilitate future discussions when addressing the biochemistry and biology of ADP-ribosylation. This is combined with a brief description of the main functions of mammalian ARTs to illustrate the increasing diversity of mono- and poly-ADP-ribose mediated cellular processes.
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| 2. |
- Benjamin, Daniel J., et al.
(författare)
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Redefine statistical significance
- 2018
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Ingår i: Nature Human Behaviour. - : Nature Research (part of Springer Nature). - 2397-3374. ; 2:1, s. 6-10
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Drögemüller, Cord, et al.
(författare)
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A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta
- 2009
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Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 5:7, s. e1000579-
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Tidskriftsartikel (refereegranskat)abstract
- Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth. Most human and some canine OI cases are caused by mutations in the COL1A1 and COL1A2 genes encoding the subunits of collagen I. Recently, mutations in the CRTAP and LEPRE1 genes were found to cause some rare forms of human OI. Many OI cases exist where the causative mutation has not yet been found. We investigated Dachshunds with an autosomal recessive form of OI. Genotyping only five affected dogs on the 50 k canine SNP chip allowed us to localize the causative mutation to a 5.82 Mb interval on chromosome 21 by homozygosity mapping. Haplotype analysis of five additional carriers narrowed the interval further down to 4.74 Mb. The SERPINH1 gene is located within this interval and encodes an essential chaperone involved in the correct folding of the collagen triple helix. Therefore, we considered SERPINH1 a positional and functional candidate gene and performed mutation analysis in affected and control Dachshunds. A missense mutation (c.977C>T, p.L326P) located in an evolutionary conserved domain was perfectly associated with the OI phenotype. We thus have identified a candidate causative mutation for OI in Dachshunds and identified a fifth OI gene.
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| 4. |
- Fehr, Ernst, et al.
(författare)
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Revealed Preferences in a Sequential Prisoners' Dilemma: A Horse-Race Between Six Utility Functions
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We experimentally investigate behavior and beliefs in a sequential prisoner’s dilemma. Each subject had to choose an action as first-mover and a conditional action as secondmover. All subjects also had to state their beliefs about others’ second-mover choices. Using the elicited beliefs, we use a novel and intuitively appealing hit-rate appraoch to compare the explanatory power of a few current models of social and moral preferences. The data show clear differences in explanatory power between the preference models, both without and with control for the number of free parameters. The best-performing models explain about 80% of observed behavior. We also compare the results with a conventional maximum-likelihood method, and conclude that results by and large agree. We finally use the estimated preference parameters to identify biases in subjects’ expectations. We find a consensus bias (whereby subjects believe others behave like themselves) and a slight optimism (whereby subjects overestimate probabilities for favorable outcomes).
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| 5. |
- Fitzal, Florian, et al.
(författare)
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Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery : Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study
- 2022
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Ingår i: Annals of Surgical Oncology. - : Springer Nature. - 1068-9265 .- 1534-4681. ; 29:2, s. 1061-1070
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Recent data suggest that margins >= 2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tubingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tubingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tubingen 3-4). Methods Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 ("ink on tumor") in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.
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| 6. |
- Miettinen, Topi, et al.
(författare)
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Revealed Preferences in a Sequential Prisoners’ Dilemma: A Horse-Race Between Five Utility Functions
- 2017
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We experimentally investigate behavior and beliefs in a sequential prisoner’s dilemma. Eachsubject had to choose an action as first-mover and a conditional action as second-mover. Allsubjects also had to state their beliefs about others’ second-mover choices. We find thatsubjects’ beliefs about others’ choices are fairly accurate on average. Using the elicited beliefs,we compare the explanatory power of a few current models of social and moral preferences. Thedata show clear differences in explanatory power between the preference models, both withoutand with control for the number of free parameters. The best-performing models explain about80% of observed behavior. We use the estimated preference parameters to identify biases insubjects’ expectations. We find a consensus bias (whereby subjects believe others behave likethemselves) and a certain optimism (whereby subjects overestimate probabilities for favorableoutcomes), the former being about twice as strong as the second.
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| 7. |
- Miettinen, Topi, et al.
(författare)
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Revealed preferences in a sequential prisoners’ dilemma: A horse-race between six utility functions
- 2020
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Ingår i: Journal of Economic Behavior and Organization. - : Elsevier. - 0167-2681. ; 173, s. 1-25
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Tidskriftsartikel (refereegranskat)abstract
- We experimentally investigate behavior and beliefs in a sequential prisoner's dilemma. Each subject had to choose an action as first mover and a conditional action as second mover. All subjects also had to state their beliefs about others’ second-mover choices. Using these elicited beliefs, we apply the transparent Selten–Krischker approach to compare the explanatory power of a few current models of social and moral preferences. We find clear differences in explanatory power between the preference models, both without and with control for the number of free parameters. The best-performing models explain about 80% of the observed behavior. We compare our results with those obtained from a conventional maximum-likelihood approach, and find that the results by and large agree. We also present a structural model of belief formation. We find a consensus bias—whereby subjects believe others behave like themselves—and payoff-salience driven optimism—whereby subjects overestimate the probabilities for favorable outcomes.
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| 8. |
- von der Fehr, Nils-Henrik M., et al.
(författare)
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Recommendations for a future-proof electricity market design in Europe in light of the 2021-23 energy crisis
- 2024
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Ingår i: Energy Policy. - : Elsevier Ltd. - 1873-6777 .- 0301-4215. ; 188
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we discuss electricity market design in Europe in light of the 2021-23 energy crisis, drawing on several of our Centre on Regulation in Europe (CERRE) reports. We outline the relevant theoretical background with respect to wholesale electricity markets, retail electricity markets, excess profits regulation, renewables support schemes and emergency interventions. We next outline the responses of the European Union, France, Norway, the Netherlands and Great Britain to the crisis. This allows us to make a number of recommendations about the future design of the electricity market in the light of theory and recent experience. These include a role for long-term contracts, the extension of the single market, the place for increased price granularity, appropriate energy taxation and the necessity of better monitoring of National Energy and Climate Plans to ensure adequate aggregate investment. •We review lessons from the EU and the reactions of four European countries to the 2021-23 energy crisis.•We summarise the theory relevant to the policy responses to the electricity crisis.•We make recommendations for future policy around electricity markets in Europe.•We find that wholesale markets performed well in the crisis, but retail markets less so.
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