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Truncated somatosta...
Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache
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- Marina, Djordje (författare)
- Copenhagen Univ Hosp, Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.
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- Burman, Pia (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skanes Univ Hosp, Dept Endocrinol, Malmo, Sweden.
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- Klose, Marianne (författare)
- Copenhagen Univ Hosp, Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.
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- Casar-Borota, Olivera (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Luque, Raul M. (författare)
- Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Dept Cell Biol Physiol & Immunol, Cordoba 14014, Spain.;CIBER Fisiopatol Obesidad & Nutr CIBERobn, Cordoba 14014, Spain.
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- Castano, Justo P. (författare)
- Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Dept Cell Biol Physiol & Immunol, Cordoba 14014, Spain.;CIBER Fisiopatol Obesidad & Nutr CIBERobn, Cordoba 14014, Spain.
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- Feldt-Rasmussen, Ulla (författare)
- Copenhagen Univ Hosp, Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark.
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Copenhagen Univ Hosp, Rigshosp, Dept Med Endocrinol, Copenhagen, Denmark Genomik, diabetes och endokrinologi (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Growth Hormone & IGF Research. - : Elsevier BV. - 1096-6374 .- 1532-2238. ; 25:5, s. 262-267
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown. Patients and methods: We investigated sst expression in two acromegalic patients with severe headache and no biochemical effects of octreotide, but a good response to pasireotide. We searched the literature for determinants of biochemical and analgesic effects of SSAs in somatotropinomas. Results: Case 1 had no biochemical or analgesic effects of octreotide, a semi-selective SSA, but a rapid and significant effect of pasireotide, a pan-SSA Case 2 demonstrated discordance between analgesic and biochemical effects of octreotide, in that headache disappeared, but without biochemical improvement. In contrast, pasireotide normalized insulin-like growth factor 1. Both adenomas were sparsely granulated and had strong membranous expressions of sst2a in 50-75% and sst5 in 75-100% of tumor cells. The truncated sst5 variant TMD4 (sst5TMD4) showed expression in 20-57% of tumor cells. Conclusions: A poor biochemical response to octreotide may be associated with tumor expression of a truncated sst5 variant, despite abundant sst2a expression, suggesting an influence from variant sst5 on common sst signaling pathways. Furthermore, unrelated analgesic and biochemical effects of SSAs supported a complex pathogenesis of acromegaly-associated headache. Finally, assessment of truncated sst5 in addition to full length sst could be important for a choice of postoperative SSA treatment in somatotropinomas.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Acromegaly
- Pasireotide
- Headache
- Analgesic effect
- Somatostatin receptors
- Truncated sst5
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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