| 1. |
- Feng, Kailun, 1991-
(författare)
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Environmentally Friendly Construction Processes Under Uncertainty : Assessment, Optimisation and Robust Decision-Making
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The construction processes of building and civil infrastructure are broadly recognised as large contributors to the environmental degradation, which cause environmental impacts directly and indirectly by massive energy use, intensive greenhouse emissions, and significant resources consumption. The report from Royal Swedish Academy of Engineering Sciences (IVA) and the Swedish Construction Federation (Byggföretagen) shows that the total carbon dioxide equivalents emitted per year from construction processes are the same size as emissions from all of the cars in Sweden, and more than that is generated by all lorries and busses. Under the current scenario of practices and technologies, 35-60% of the remaining carbon budget of Paris Agreement in next 30 years would be taken by construction processes. To follow the fossil free Sweden initiative, Swedish construction and civil engineering sector has set the roadmap to reduce the greenhouse gas emissions of construction processes by 50% from 2015 to 2030 and reach net-zero emissions by 2045.Construction processes are usually carried out in contexts full of uncertainty, which causes significant challenges to achieve the target of environmentally friendly construction. The reasons can be summarised as three aspects. Firstly, most of related environmental impact assessment methods still base on static data, which lack the ability to capture the influence of uncertainty in an environmental assessment. Secondly, the uncertainty in construction processes leads to high level of computational loads, which results in that current studies present limitations on effectively providing real-time environmental optimisation. Thirdly, the robust decision-making has been proposed as an enabling method to yield decisions with robust performances with relatively less influences by uncertainty. However, current robust decision-making methods sometimes are not applicable for construction environmentally friendly decisions because the knowledge of uncertainty such as prior probability distributions are partly unknown due to characteristics of construction.The overall purpose of this thesis, therefore, was to formulate a holistic approach to assess, optimise and provide robust decision-making for environmentally friendly construction under the uncertain contexts. The developed environmental impact assessment method integrates discrete-event simulation (DES) and process-based life-cycle assessment (pLCA). It takes advantage of discrete-event simulation to reinforce the uncertainty analysis ability of conventional environmental assessment methods. The optimisation method achieves real-time environmental optimisation by introducing machine learning (ML) technology into simulation-based optimisation. It significantly reduces the computational loads of optimisation by the ML’s real-time feedback ability during uncertainty quantification. The developed robust decision-making method combines discrete-event simulation (DES) and data mining (DM) technologies to address the uncertain contexts of construction. It utilities construction performance dataset, i.e. a data-driven method, to quantify the robustness and identify the vulnerability of environmentally friendly decisions in the situation of partly unknown probability distributions.To achieve research purpose, the research is designed as an explorative procedure in a loop of (1) problem identification, (2) method development, and (3) method examination. In the first step, the requirements of environmentally friendly construction in real practices are identified, the current limitations and knowledge gaps that block the environmentally friendly construction are revealed. In the second step, to solve the identified problems, the holistic approach is designed. The theoretical methods that base on relevant theories are established, and prototypes that base on relevant technologies are developed. In the last step, the holistic approach is implemented into real construction cases. The procedure will be loop to solve identified problems until the research purpose has been fully achieved.The research provides a systematic tool to handle uncertainty and to support environmentally friendly construction practices for project decision-makers. Firstly, developed approach enables to assess the environmental impacts of construction processes involving uncertainty, which help to better understand the influences of uncertainty and develop construction planning that can improve the environmental performance. And the optimisation section enables the real-time decision support of an environmental optimisation by considering multi-objective and in a great deal of construction alternatives, which helps to efficiently narrow down numerous construction alternatives and provide practical environmentally optimal planning. Finally, it provides the decision-makers with robust environmentally friendly decisions on the construction planning that are least affected by uncertainty, and provides vulnerable scenarios of uncertain factors for an informed uncertainty management in the progress of construction.
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| 2. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 3. |
- Postmus, Iris, et al.
(författare)
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Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
- 2014
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
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