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ENETS Consensus Gui...
ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : Biochemical Markers
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- Öberg, Kjell, 1946- (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Couvelard, Anne (författare)
- Hospital Beaujon, Department of Pathology
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- Delle Fave, Gianfranco (författare)
- Ospedale Sant’Andrea, Department of Digestive and Liver Disease
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- Gross, David (författare)
- Hadassah University Hospital, Department of Endocrinology and Metabolism
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- Grossman, Ashley (författare)
- University of Oxford, Churchill Hospital, Oxford Centre for Diabetes, Endocrinology and Metabolism
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- Jensen, Robert T. (författare)
- National Institutes of Health, Digestive Diseases Branch
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- Pape, Ulrich-Frank (författare)
- Charité University of Berlin, Department of Internal Medicine
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- Perren, Aurel (författare)
- niversity Hospital Zurich, Department of Pathology
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- Rindi, Guido (författare)
- Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Institute of Anatomic Pathology
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- Ruszniewski, Philippe (författare)
- Beaujon Hopital, Department of Gastroenterology
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- Scoazec, Jean-Yves (författare)
- Gustave Roussy Institute, Department of Biopathology, Faculty of Medicine Paris Sud
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- Welin, Staffan (författare)
- Uppsala universitet,Onkologisk endokrinologi
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- Wiedenmann, Bertram (författare)
- Charité University Medicine, Department of Hepatology and Gastroenterology
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- Ferone, Diego (författare)
- University of Genova, IRCCS AOU San Martino IST, DiMI, CEBR
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(creator_code:org_t)
- 2017-04-08
- 2017
- Engelska.
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Ingår i: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 105:3, s. 201-211
- Relaterad länk:
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https://boris.unibe....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biomarkers have been the mainstay in the diagnosis and follow-up of patients with neuroendocrine tumors (NETs) over the last few decades. In the beginning, secretory products from a variety of subtypes of NETs were regarded as biomarkers to follow during diagnosis and treatment: serotonin for small intestinal (SI) NETs, and gastrin and insulin for pancreatic NETs. However, it became evident that a large number of NETs were so-called nonfunctioning tumors without secreting substances that caused hormone-related symptoms. Therefore, it was necessary to develop so-called "general tumor markers." The most important ones so far have been chromogranin A and neuron-specific enolase (NSE). Chromogranin A is the most important general biomarker for most NETs with a sensitivity and specificity somewhere between 60 and 90%. NSE has been a relevant biomarker for patients with high-grade tumors, particularly lung and gastrointestinal tract tumors. Serotonin and the breakdown product urinary 5-hydroxyindoleacetic acid (U-5-HIAA) is still an important marker for diagnosing and follow-up of SI NETs. Recently, 5-HIAA in plasma has been analyzed by highperformance liquid chromatography and fluorometric detection and has shown good agreement with U-5-HIAA anal ysis. In the future, we will see new tests including circulating tumor cells, circulating DNA and mRNA. Recently, a NET test has been developed analyzing gene transcripts in circulating blood. Preliminary data indicate high sensitivity and specificity for NETs. However, its precise role has to be validated in prospective randomized controlled trials which are ongoing right now.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Biomarkers
- Chromogranin A
- Urinary 5-hydroxyindoleacetic acid
- Neuroendocrine tumor test
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Öberg, Kjell, 19 ...
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Couvelard, Anne
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Delle Fave, Gian ...
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Gross, David
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Grossman, Ashley
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Jensen, Robert T ...
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Pape, Ulrich-Fra ...
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Perren, Aurel
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Rindi, Guido
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Ruszniewski, Phi ...
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Scoazec, Jean-Yv ...
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Welin, Staffan
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Wiedenmann, Bert ...
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Ferone, Diego
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Neuroendocrinolo ...
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Uppsala universitet