SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Forouhi N. G.) ;spr:eng"

Sökning: WFRF:(Forouhi N. G.) > Engelska

  • Resultat 1-10 av 77
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Glasbey, JC, et al. (författare)
  • 2021
  • swepub:Mat__t
  •  
2.
  • 2021
  • swepub:Mat__t
  •  
3.
  • 2021
  • swepub:Mat__t
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  • Palmer, Nicholette D, et al. (författare)
  • A genome-wide association search for type 2 diabetes genes in African Americans.
  • 2012
  • Ingår i: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202-
  • Tidskriftsartikel (refereegranskat)abstract
    • African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
  •  
8.
  •  
9.
  •  
10.
  • Jiang, X., et al. (författare)
  • Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
  • 2018
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 77
Typ av publikation
tidskriftsartikel (72)
forskningsöversikt (2)
Typ av innehåll
refereegranskat (73)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Wareham, Nicholas J. (32)
Langenberg, Claudia (24)
Lind, Lars (23)
Langenberg, C. (22)
Franks, Paul W. (22)
Rolandsson, Olov (20)
visa fler...
Laakso, Markku (20)
Luan, Jian'an (18)
Franks, Paul (17)
Groop, Leif (17)
Tanaka, Toshiko (17)
Schulze, Matthias B. (16)
Ferrucci, Luigi (16)
Overvad, Kim (15)
Tumino, Rosario (15)
Riboli, Elio (15)
Panico, Salvatore (15)
Ingelsson, Erik (15)
Forouhi, NG (15)
Loos, Ruth J F (15)
Siscovick, David S. (15)
Sharp, Stephen J. (15)
Renström, Frida (14)
Tuomilehto, Jaakko (14)
Lemaitre, Rozenn N. (14)
Balkau, B. (13)
Mozaffarian, Dariush (13)
Froguel, P (13)
Kuusisto, Johanna (13)
McCarthy, Mark I (13)
Boehnke, Michael (13)
Laakso, M. (13)
Lind, L (13)
Wareham, NJ (13)
Hofman, Albert (13)
Uitterlinden, André ... (13)
Jackson, Anne U. (13)
Overvad, K (12)
Sacerdote, Carlotta (12)
Khaw, Kay-Tee (12)
Wareham, N. J. (12)
Pedersen, NL (12)
Loos, RJF (12)
van Duijn, Cornelia ... (12)
Mohlke, Karen L (12)
de Faire, U (12)
Gudnason, Vilmundur (12)
van der Schouw, Yvon ... (12)
Prokopenko, Inga (12)
Vollenweider, Peter (12)
visa färre...
Lärosäte
Lunds universitet (49)
Umeå universitet (47)
Karolinska Institutet (38)
Uppsala universitet (33)
Göteborgs universitet (14)
Högskolan Dalarna (6)
Språk
Engelska (77)Ta bort avgränsningen
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (70)
Naturvetenskap (4)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy