SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Forsberg Lars A) "

Sökning: WFRF:(Forsberg Lars A)

  • Resultat 1-10 av 50
  • [1]2345Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Dimakopoulou, Konstantina, et al. (författare)
  • Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project
  • 2014
  • Ingår i: American Journal of Respiratory and Critical Care Medicine. - Am Thoracic Soc. - 1073-449X. ; 189:6, s. 684-696
  • Tidskriftsartikel (refereegranskat)abstract
    • Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratorymortality.
  •  
2.
  • Beelen, Rob, et al. (författare)
  • Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project
  • 2014
  • Ingår i: Lancet (London, England). - 1474-547X. ; 383:9919, s. 785-795
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Few studies on long-term exposure to air pollution and mortality have been reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aimed to investigate the association between natural-cause mortality and long-term exposure to several air pollutants. Methods We used data from 22 European cohort studies, which created a total study population of 367 251 participants. All cohorts were general population samples, although some were restricted to one sex only. With a strictly standardised protocol, we assessed residential exposure to air pollutants as annual average concentrations of particulate matter (PM) with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM 10), and between 10 μm and 2.5 μm (PMcoarse), PM2.5 absorbance, and annual average concentrations of nitrogen oxides (NO2 and NOx) with land use regression models. We also investigated two traffic intensity variables-traffic intensity on the nearest road (vehicles per day) and total traffic load on all major roads within a 100 m buffer. We did cohort-specific statistical analyses using confounder models with increasing adjustment for confounder variables, and Cox proportional hazards models with a common protocol. We obtained pooled effect estimates through a random-effects metaanalysis. Findings The total study population consisted of 367 251 participants who contributed 5 118 039 person-years at risk (average follow-up 13.9 years), of whom 29 076 died from a natural cause during follow-up. A significantly increased hazard ratio (HR) for PM2.5 of 1.07 (95% CI 1.02-1.13) per 5 μg/m3 was recorded. No heterogeneity was noted between individual cohort effect estimates (I2 p value=0.95). HRs for PM2.5 remained significantly raised even when we included only participants exposed to pollutant concentrations lower than the European annual mean limit value of 25 μg/m3 (HR 1.06, 95% CI 1.00-1.12) or below 20 μg/m3 (1.07, 1.01-1.13). Interpretation Long-term exposure to fine particulate air pollution was associated with natural-cause mortality, even within concentration ranges well below the present European annual mean limit value.
  •  
3.
  • Raaschou-Nielsen, Ole, et al. (författare)
  • Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)
  • 2013
  • Ingår i: The Lancet. Oncology. - 1474-5488. ; 14:9, s. 813-822
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. Methods: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses. Findings: The 312-944 cohort members contributed 4-013-131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95% CI 1·03-1·45] per 10 μg/m3). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m3. The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m3) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day). Interpretation: Particulate matter air pollution contributes to lung cancer incidence in Europe. Funding: European Community's Seventh Framework Programme.
  •  
4.
  • Chase, A., et al. (författare)
  • Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus
  • 2015
  • Ingår i: Leukemia. - 0887-6924 .- 1476-5551. ; 29:10, s. 2069-2074
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Acquired uniparental disomy (aUPD) is a common finding in myeloid malignancies and typically acts to convert a somatically acquired heterozygous mutation to homozygosity. We sought to identify the target of chromosome 14 aUPD (aUPD14), a recurrent abnormality in myeloid neoplasms and population cohorts of elderly individuals. We identified 29 cases with aUPD14q that defined a minimal affected region (MAR) of 11.2 Mb running from 14q32.12 to the telomere. Exome sequencing (n = 7) did not identify recurrently mutated genes, but methylation-specific PCR at the imprinted MEG3-DLK1 locus located within the MAR demonstrated loss of maternal chromosome 14 and gain of paternal chromosome 14 (P &lt; 0.0001), with the degree of methylation imbalance correlating with the level of aUPD (r = 0.76; P = 0.0001). The absence of driver gene mutations in the exomes of three individuals with aUPD14q but no known haematological disorder suggests that aUPD14q may be sufficient to drive clonal haemopoiesis. Analysis of cases with both aUPD14q and JAK2 V617F (n = 11) indicated that aUPD14q may be an early event in some cases but a late event in others. We conclude that aUPD14q is a recurrent abnormality that targets an imprinted locus and may promote clonal haemopoiesis either as an initiating event or as a secondary change.</p>
  •  
5.
  •  
6.
  • Dumanski, Jan P., et al. (författare)
  • Mutagenesis : smoking is associated with mosaic loss of chromosome Y
  • 2015
  • Ingår i: Science. - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.</p>
  •  
7.
  • Dumanski, Jan P, et al. (författare)
  • Smoking is associated with mosaic loss of chromosome Y
  • 2015
  • Ingår i: Science. - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.</p>
  •  
8.
  •  
9.
  • Dumanski, Jan P, et al. (författare)
  • Smoking is associated with mosaic loss of chromosome Y
  • 2015
  • Ingår i: Science. - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.</p>
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 50
  • [1]2345Nästa
Åtkomst
fritt online (9)
Typ av publikation
tidskriftsartikel (43)
forskningsöversikt (4)
konferensbidrag (3)
Typ av innehåll
refereegranskat (45)
övrigt vetenskapligt (10)
Författare/redaktör
Dumanski, Jan P (16)
Lannfelt, Lars, (10)
Giedraitis, Vilmanta ... (9)
Lind, Lars, (8)
Ingelsson, Martin, (8)
Pedersen, Nancy L (7)
visa fler...
Ingelsson, Erik (7)
Forsberg, Bertil, (6)
Modig, Lars, (6)
Morris, Andrew P. (6)
Lindgren, Cecilia M. (6)
Forsberg, B. (5)
Magnusson, Patrik K ... (5)
Tiensuu Janson, Eva, (5)
Absher, Devin (5)
Johannesson,, Magnus (5)
Lönn, Mikael (5)
Cesarini, David (5)
Peeters, Petra H. (4)
Trichopoulou, Antoni ... (4)
Sacerdote, Carlotta (4)
Wang, Meng, (4)
Eeftens, Marloes (4)
Tsai, Ming-Yi (4)
de Hoogh, Kees (4)
Beelen, Rob (4)
Hoek, Gerard (4)
Brunekreef, Bert (4)
Modig, L. (4)
Nagel, Gabriele (4)
Bueno-de-Mesquita, B ... (4)
Vineis, Paolo (4)
Ricceri, Fulvio, (4)
Fratiglioni, Laura, (4)
Hoek, G (4)
de Faire, U, (4)
de Faire, Ulf (4)
Katsouyanni, Klea (4)
Weinmayr, Gudrun (4)
Stafoggia, Massimo (4)
Oftedal, Bente (4)
Korek, Michal (4)
Raaschou-Nielsen, Ol ... (4)
Oudin, Anna, (4)
Fischer, Paul (4)
Dimakopoulou, Konsta ... (4)
Hoffmann, Barbara (4)
Samoli, Evangelia (4)
Nafstad, Per (4)
Penell, Johanna (4)
visa färre...
Lärosäte
Uppsala universitet (20)
Lunds universitet (9)
Karolinska Institutet (6)
Göteborgs universitet (5)
Södertörns högskola (4)
Stockholms universitet (3)
visa fler...
Linköpings universitet (3)
Umeå universitet (2)
Kungliga Tekniska Högskolan (2)
Högskolan i Gävle (2)
Mittuniversitetet (1)
visa färre...
Språk
Engelska (50)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (29)
Naturvetenskap (12)
Teknik (3)
Lantbruksvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy