| 1. |
|
|
| 2. |
- Höckerfelt, U, et al.
(författare)
-
Substance P (NK1) receptor in relation to substance P innervation in rat duodenum after irradiation.
- 2001
-
Ingår i: Regulatory Peptides. - 0167-0115 .- 1873-1686. ; 98:3, s. 115-26
-
Tidskriftsartikel (refereegranskat)abstract
- It has previously been shown that high dose of irradiation to the rat abdomen leads to an increased level of substance P (SP) in the duodenum. In the present study the pattern of distribution of NK1 receptors (NK1-R) in rat duodenum after irradiation (5-30 Gy), was examined at the same time-point (7 days) after irradiation, comparisons being made with the distribution of SP-innervation. Immunohistochemical methods were used. In controls, NK1-R-like immunoreactivity (-LI) was detected in epithelial cells, in cells in the region of the intestinal cells of Cajal within the deep muscular plexus (ICC-DMP), in neuronal cells in the myenteric plexus, and variably in granulocytes in the mucosa. Irradiation with 5-10 Gy did not lead to obvious changes in the pattern of NK1-R-LI. After irradiation with the highest doses (25-30 Gy), the mucosa was often gravely damaged, displaying granulation tissue. No epithelial NK1-R-LI was detected in this tissue, but was present in less affected mucosa after these doses. In the region of the ICC-DMP, in the myenteric plexus, and in granulocytes, NK1-R-LI was detected also after high dose irradiation. However, the degree of NK1-R-LI in the region of the ICC-DMP was somewhat lower than seen in controls and after low doses. SP-immunoreactive nerve fibers were present in the regions where NK1-R-LI was detected. These findings support a suggestion that an increased level of SP after irradiation may contribute to the dose-dependent gastrointestinal adverse effects that occur after radiotherapy.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Persson-Sjögren, S, et al.
(författare)
-
Mouse islets cultured with vasoactive intestinal polypeptide : effects on insulin release and immunoreactivity for tyrosine hydroxylase.
- 2001
-
Ingår i: Pancreas. - 0885-3177 .- 1536-4828. ; 22:1, s. 84-90
-
Tidskriftsartikel (refereegranskat)abstract
- Mouse islets cultured for 1 or 4 days with or without 10 nM vasoactive intestinal polypeptide (VIP) were stained for tyrosine hydroxylase (TH) and examined for insulin secretion during culture and in a postculture perifusion system. Exposure to exogenous VIP for 4 days increased the frequency of islet cells expressing TH-like immunoreactivity. Regardless of the culturing conditions, the islets exhibited significant insulin secretory responses to 16.7 mM glucose, the effect being potentiated by 10 nM VIP in the perifusion medium. The insulin-releasing action of glucose and the potentiating effect of VIP were less pronounced in islets cultured for 1 day with VIP than in islets cultured without this neuropeptide. The following conclusions are suggested: (a) VIP stimulates the expression of TH in mouse islet cells; (b) the latency of the VIP-induced TH is a postreceptor phenomenon; (c) islet cultures exposed to VIP represent a new instance of the association between increased functional demands on beta cells and enhanced expression of TH and a new instance of VIP having trophic effects.
|
|
| 6. |
|
|
| 7. |
- Tingaker, BK, et al.
(författare)
-
NGF-A labor pain mediator?
- 2007
-
Ingår i: ANESTHESIOLOGY. - 0003-3022. ; 106:5, s. B42-B42
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
