| 1. |
- Nyberg, Lars, et al.
(författare)
-
Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations
- 2009
-
Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 46:4, s. 1194-1199
-
Tidskriftsartikel (refereegranskat)abstract
- Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.
|
|
| 2. |
- Marklund, Petter, 1968-, et al.
(författare)
-
Temporal dynamics of basal ganglia under-recruitment in Parkinson's disease : transient caudate abnormalities during updating of working memory
- 2009
-
Ingår i: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 132:2, s. 336-346
-
Tidskriftsartikel (refereegranskat)abstract
- Using hybrid-blocked/event-related fMRI and the 2-back taskwe aimed to decompose tonic and phasic temporal dynamics ofbasal ganglia response abnormalities in working memory associatedwith early untreated Parkinson's disease. In view of the tonic/phasicdopamine hypothesis, which posits a functional division betweenphasic D2-dependent striatal updating processes and tonic D1-dependentprefrontal context-maintenance processes, we predicted thatnewly diagnosed, drug-naïve Parkinson's disease patients,with selective striatal dopamine deprivation, would demonstratetransient rather than sustained activation changes in the basalganglia during 2-back performance. Task-related activation patternswithin discrete basal ganglia structures were directly comparedbetween patients and healthy elderly controls. The obtainedresults yielded uniquely transient underactivation foci in caudatenuclei, putamen and globus pallidus in Parkinson's disease patients,which indicates suboptimal phasic implementation of striatalD2-dependent gating mechanisms during updating. Sustained underactivationwas only seen in the anterior putamen, which may reflect initialsigns of tonic control impairment. No significant changes wereexhibited in prefrontal cortex. The present findings resonatewell with the tonic/phasic dopamine account and suggest thatbasal ganglia under-recruitment associated with executive dysfunctionin early Parkinson's disease might predominantly stem from deficienciesin phasic executive components subserved by striatum.
|
|
| 3. |
- Forsgren, Olov, et al.
(författare)
-
Co-constructive e-power loop - Citizen driven innovation in Region Vasterbotten, Northern Sweden
- 2014
-
Ingår i: 2014 IST-AFRICA Conference Proceedings. - : International Information Management Corporation Limited. - 9781905824441 ; , s. 1-6
-
Konferensbidrag (refereegranskat)abstract
- This report describes the background, and related theories, results and reflections based on a research - innovation (R&D model comprising multi-stakeholder co-creative workshops. The resulting new concepts, solutions and prototypes produced in a short limited time-scale are extraordinary compared to the outcome of standard research and innovation approaches. The developed prototypes and work-processes and the performed R&I model have in a positive way changed attitudes among many key stakeholders, leading to the start of new R&D programs pushing development of citizen centric services towards building a foundation for positive living areas.
|
|
| 4. |
|
|
