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Loci influencing blood pressure identified using a cardiovascular gene-centric array

Ganesh, Santhi K. (author)
Tragante, Vinicius (author)
Guo, Wei (author)
show more...
Guo, Yiran (author)
Lanktree, Matthew B. (author)
Smith, Erin N. (author)
Johnson, Toby (author)
Castillo, Berta Almoguera (author)
Barnard, John (author)
Baumert, Jens (author)
Chang, Yen-Pei Christy (author)
Elbers, Clara C. (author)
Farrall, Martin (author)
Fischer, Mary E. (author)
Franceschini, Nora (author)
Gaunt, Tom R. (author)
Gho, Johannes M. I. H. (author)
Gieger, Christian (author)
Gong, Yan (author)
Isaacs, Aaron (author)
Kleber, Marcus E. (author)
Leach, Irene Mateo (author)
McDonough, Caitrin W. (author)
Meijs, Matthijs F. L. (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Molony, Cliona M. (author)
Nolte, Ilja M. (author)
Padmanabhan, Sandosh (author)
Price, Tom S. (author)
Rajagopalan, Ramakrishnan (author)
Shaffer, Jonathan (author)
Shah, Sonia (author)
Shen, Haiqing (author)
Soranzo, Nicole (author)
van der Most, Peter J. (author)
Van Iperen, Erik P. A. (author)
Van Setten, Jessic A. (author)
Vonk, Judith M. (author)
Zhang, Li (author)
Beitelshees, Amber L. (author)
Berenson, Gerald S. (author)
Bhatt, Deepak L. (author)
Boer, Jolanda M. A. (author)
Boerwinkle, Eric (author)
Burkley, Ben (author)
Burt, Amber (author)
Chakravarti, Aravinda (author)
Chen, Wei (author)
Cooper-DeHoff, Rhonda M. (author)
Curtis, Sean P. (author)
Dreisbach, Albert (author)
Duggan, David (author)
Ehret, Georg B. (author)
Fabsitz, Richard R. (author)
Fornage, Myriam (author)
Fox, Ervin (author)
Furlong, Clement E. (author)
Gansevoort, Ron T. (author)
Hofker, Marten H. (author)
Hovingh, G. Kees (author)
Kirkland, Susan A. (author)
Kottke-Marchant, Kandice (author)
Kutlar, Abdullah (author)
LaCroix, Andrea Z. (author)
Langaee, Taimour Y. (author)
Li, Yun R. (author)
Lin, Honghuang (author)
Liu, Kiang (author)
Maiwald, Steffi (author)
Malik, Rainer (author)
Murugesan, Gurunathan (author)
Newton-Cheh, Christopher (author)
OConnell, Jeffery R. (author)
Onland-Moret, N. Charlotte (author)
Ouwehand, Willem H. (author)
Palmas, Walter (author)
Penninx, Brenda W. (author)
Pepine, Carl J. (author)
Pettinger, Mary (author)
Polak, Joseph F. (author)
Ramachandran, Vasan S. (author)
Ranchalis, Jane (author)
Redline, Susan (author)
Ridker, Paul M. (author)
Rose, Lynda M. (author)
Scharnag, Hubert (author)
Schork, Nicholas J. (author)
Shimbo, Daichi (author)
Shuldiner, Alan R. (author)
Srinivasan, Sathanur R. (author)
Stolk, Ronald P. (author)
Taylor, Herman A. (author)
Thorand, Barbara (author)
Trip, Mieke D. (author)
van Duijn, Cornelia M. (author)
Verschuren, W. Monique (author)
Wijmenga, Cisca (author)
Winkelmann, Bernhard R. (author)
Wyatt, Sharon (author)
Young, J. Hunter (author)
Boehm, Bernhard O. (author)
Caulfield, Mark J. (author)
Chasman, Daniel I. (author)
Davidson, Karina W. (author)
Doevendans, Pieter A. (author)
FitzGerald, Garret A. (author)
Gums, John G. (author)
Hakonarson, Hakon (author)
Hillege, Hans L. (author)
Illig, Thomas (author)
Jarvik, Gail P. (author)
Johnson, Julie A. (author)
Kastelein, John J. P. (author)
Koenig, Wolfgang (author)
Maerz, Winfried (author)
Mitchell, Braxton D. (author)
Murray, Sarah S. (author)
Oldehinkel, Albertine J. (author)
Rader, Daniel J. (author)
Reilly, Muredach P. (author)
Reiner, Alex P. (author)
Schadt, Eric E. (author)
Silverstein, Roy L. (author)
Snieder, Harold (author)
Stanton, Alice V. (author)
Uitterlinden, Andre G. (author)
van der Harst, Pim (author)
van der Schouw, Yvonne T. (author)
Samani, Nilesh J. (author)
Johnson, Andrew D. (author)
Munroe, Patricia B. (author)
de Bakker, Paul I. W. (author)
Zhu, Xiaofeng (author)
Levy, Daniel (author)
Keating, Brendan J. (author)
Asselbergs, Folkert W. (author)
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 (creator_code:org_t)
2013-01-08
2013
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 22:8, s. 1663-1678
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P 2.4 10(6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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Ganesh, Santhi K ...
Tragante, Vinici ...
Guo, Wei
Guo, Yiran
Lanktree, Matthe ...
Smith, Erin N.
show more...
Johnson, Toby
Castillo, Berta ...
Barnard, John
Baumert, Jens
Chang, Yen-Pei C ...
Elbers, Clara C.
Farrall, Martin
Fischer, Mary E.
Franceschini, No ...
Gaunt, Tom R.
Gho, Johannes M. ...
Gieger, Christia ...
Gong, Yan
Isaacs, Aaron
Kleber, Marcus E ...
Leach, Irene Mat ...
McDonough, Caitr ...
Meijs, Matthijs ...
Melander, Olle
Molony, Cliona M ...
Nolte, Ilja M.
Padmanabhan, San ...
Price, Tom S.
Rajagopalan, Ram ...
Shaffer, Jonatha ...
Shah, Sonia
Shen, Haiqing
Soranzo, Nicole
van der Most, Pe ...
Van Iperen, Erik ...
Van Setten, Jess ...
Vonk, Judith M.
Zhang, Li
Beitelshees, Amb ...
Berenson, Gerald ...
Bhatt, Deepak L.
Boer, Jolanda M. ...
Boerwinkle, Eric
Burkley, Ben
Burt, Amber
Chakravarti, Ara ...
Chen, Wei
Cooper-DeHoff, R ...
Curtis, Sean P.
Dreisbach, Alber ...
Duggan, David
Ehret, Georg B.
Fabsitz, Richard ...
Fornage, Myriam
Fox, Ervin
Furlong, Clement ...
Gansevoort, Ron ...
Hofker, Marten H ...
Hovingh, G. Kees
Kirkland, Susan ...
Kottke-Marchant, ...
Kutlar, Abdullah
LaCroix, Andrea ...
Langaee, Taimour ...
Li, Yun R.
Lin, Honghuang
Liu, Kiang
Maiwald, Steffi
Malik, Rainer
Murugesan, Gurun ...
Newton-Cheh, Chr ...
OConnell, Jeffer ...
Onland-Moret, N. ...
Ouwehand, Willem ...
Palmas, Walter
Penninx, Brenda ...
Pepine, Carl J.
Pettinger, Mary
Polak, Joseph F.
Ramachandran, Va ...
Ranchalis, Jane
Redline, Susan
Ridker, Paul M.
Rose, Lynda M.
Scharnag, Hubert
Schork, Nicholas ...
Shimbo, Daichi
Shuldiner, Alan ...
Srinivasan, Sath ...
Stolk, Ronald P.
Taylor, Herman A ...
Thorand, Barbara
Trip, Mieke D.
van Duijn, Corne ...
Verschuren, W. M ...
Wijmenga, Cisca
Winkelmann, Bern ...
Wyatt, Sharon
Young, J. Hunter
Boehm, Bernhard ...
Caulfield, Mark ...
Chasman, Daniel ...
Davidson, Karina ...
Doevendans, Piet ...
FitzGerald, Garr ...
Gums, John G.
Hakonarson, Hako ...
Hillege, Hans L.
Illig, Thomas
Jarvik, Gail P.
Johnson, Julie A ...
Kastelein, John ...
Koenig, Wolfgang
Maerz, Winfried
Mitchell, Braxto ...
Murray, Sarah S.
Oldehinkel, Albe ...
Rader, Daniel J.
Reilly, Muredach ...
Reiner, Alex P.
Schadt, Eric E.
Silverstein, Roy ...
Snieder, Harold
Stanton, Alice V ...
Uitterlinden, An ...
van der Harst, P ...
van der Schouw, ...
Samani, Nilesh J ...
Johnson, Andrew ...
Munroe, Patricia ...
de Bakker, Paul ...
Zhu, Xiaofeng
Levy, Daniel
Keating, Brendan ...
Asselbergs, Folk ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
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Human Molecular ...
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