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- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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- Altincekic, Nadide, et al.
(författare)
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Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies
- 2024
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Ingår i: ACS Chemical Biology. - : American Chemical Society (ACS). - 1554-8929 .- 1554-8937. ; 19:2, s. 563-574
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Tidskriftsartikel (refereegranskat)abstract
- The main protease Mpro, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four different libraries and detailed follow-up synthesis on the promising uracil-containing fragment Z604 derived from these libraries. Z604 shows time-dependent binding. Its inhibitory effect is sensitive to reducing conditions. Starting with Z604, we synthesized and characterized 13 compounds designed by fragment growth strategies. Each compound was characterized by NMR and/or activity assays to investigate their interaction with Mpro. These investigations resulted in the four-armed compound 35b that binds directly to Mpro. 35b could be cocrystallized with Mpro revealing its noncovalent binding mode, which fills all four active site subpockets. Herein, we describe the NMR-derived fragment-to-hit pipeline and its application for the development of promising starting points for inhibitors of the main protease of SCoV2.
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| 4. |
- Andersson, Malte, 1941, et al.
(författare)
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”Minskande befolkning är inte problemet”
- 2020
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Ingår i: Dagens Nyheter. ; :1 augusti, DN-debatt
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Nätverket Population Matters Sweden: En uppmärksammad studie i The Lancet pekar mot en lägre befolkningsökning i världen än tidigare prognoser. Men en miljard människor till är fortfarande långt över vad jorden klarar. Befolkningstrenden måste snarare vända neråt, och det kräver åtgärder för att stärka kvinnors rättigheter världen över.
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| 7. |
- Fridman, Jonas, et al.
(författare)
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Education and advice contribute to increased density of broadleaved conservation trees, but not saplings, in young forest in Sweden
- 2009
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Ingår i: Journal of Environmental Management. - : Elsevier BV. - 0301-4797 .- 1095-8630. ; 90, s. 1081–1088-
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Tidskriftsartikel (refereegranskat)abstract
- The effectiveness of different conservation policies is debated, but the policies are rarely evaluated quantitatively. A voluntary or ‘soft’ policy based mainly on education provides information about ecosystems and effects of land use, to encourage conservation action. Swedish forestry relies mainly on soft policy, with substantial resources for education and advice to more than 200,000 forest owners, while legal regulation is weak. Increased retention of broadleaved trees at clear-cutting, with environmental benefits in the conifer-dominated forestry, is important in the policy. We used the Swedish National Forest Inventory to analyse this policy for young forests in southern Sweden. Between 1983–1987 and 1998–2002 the policy had no positive effect on saplings (1.3 m tall to 4.9 cm dbh) of birch, oak, beech and other species that mostly decreased in density, due to planting of conifers and browsing by ungulates. However, broadleaved conservation trees (??15 cm dbh) increased in density, e.g. to about one oak and six birches per ha in young coniferous forest in 1998–2002. The relative increase in density was higher for large (??20 cm dbh) than for small trees (15–20 cm dbh). The density of conservation trees was higher on forestland of high than of low productivity. Thus, the soft conservation policy did not influence regeneration of saplings in this type of forestry system, but large broadleaved trees were increasingly saved at ‘clear-cuttings’. Advice and educational programmes probably contributed to this result. A continued increase in conservation trees at harvest may require economical support to forest owners
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- Götmark, Frank, 1955, et al.
(författare)
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Broadleaved tree species in conifer-dominated forestry: Regeneration and limitation of saplings in southern Sweden
- 2005
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Ingår i: Forest Ecology and Management. - : Elsevier BV. - 0378-1127. ; 214:1-3, s. 142-157
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Tidskriftsartikel (refereegranskat)abstract
- Forests and forestry in Sweden are dominated by conifers. Silviculture using mixed or broadleaved stands is often recommended, but the degree to which broadleaves regenerate naturally needs to be clarified. The Swedish National Forest Inventory is here used for a region-wide study of broadleaved saplings (1.3 m tall to 4.9 cm dbh) regenerated naturally. For 12 species (taxa) in young forests (< 7 m tall) and high forests (> 7 m), sapling densities were related to seven forest types and three productivity classes. Birch had highest densities in all but two broadleaved forest types. Birch, oak, rowan and sallow had 70-85% of their total sapling populations in conifer-dominated forest types, indicating good potential for mixed stands. Beech, lime, hornbeam, ash and elm were mostly restricted to 'noble' (hardwood) forests. The regeneration success (saplings per mature tree) for birch, rowan and oak was highest in conifer-dominated forest; beech was about equally successful in conifer-dominated and broadleaved forests, and ash was very successful in broadleaved forest. Oak regeneration may be problematical in broadleaved forests, but we suggest this is not the case in conifer-dominated forests (where oaks have rarely been studied). Sapling densities of the species in the forest types were not consistently correlated with productivity, but birch and aspen generally regenerated strongest at intermediate and at high productivity, respectively. In noble forests, oak, ash and elm regenerated strongest at low productivity. The role of asexual regeneration (sprouting) remains to clarify. Our results suggest that lime, elm, ash and some other trees currently are limited mainly by poor dispersal, rather than habitat availability. The results are promising for various forms of mixed-species forestry that does not require planting (or little planting) and that would be beneficial for nature conservation. (c) 2005 Elsevier B.V. All rights reserved.
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| 10. |
- Götmark, Frank, 1955, et al.
(författare)
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FN bör ha som mål att bromsa folkökningen
- 2018
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Ingår i: Svenska Dagbladet (SvD-Debatt, 22 juli).
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- I diskussionen om miljö och vår framtid bör också överbefolkning lyftas fram. Frågan undviks ofta i samhällsdebatten – trots att den är central. Vi uppmanar den svenska regeringen att ta upp frågan i FN, skriver flera debattörer.
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