Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Landén, Mikael, 1966 (author): Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Dinga, R. (author)

Hahn, T. (author)

Ching, C. R. K. (author)

Eyler, L. T. (author)

Aftanas, L. (author)

Aghajani, M. (author)

Aleman, A. (author)

Baune, B. T. (author)

Berger, K. (author)

Brak, I. (author)

Filho, G. B. (author)

Carballedo, A. (author): Karolinska Institutet

Connolly, C. G. (author)

Couvy-Duchesne, B. (author)

Cullen, K. R. (author)

Dannlowski, U. (author)

Davey, C. G. (author)

Dima, D. (author)

Duran, F. L. S. (author)

Enneking, V. (author)

Filimonova, E. (author)

Frenzel, S. (author)

Frodl, T. (author)

Fu, C. H. Y. (author)

Godlewska, B. R. (author)

Gotlib, I. H. (author)

Grabe, H. J. (author)

Groenewold, N. A. (author)

Grotegerd, D. (author)

Gruber, O. (author)

Hall, G. B. (author)

Harrison, B. J. (author)

Hatton, S. N. (author)

Hermesdorf, M. (author)

Hickie, I. B. (author)

Ho, T. C. (author)

Hosten, N. (author)

Jansen, A. (author)

Kähler, C. (author)

Kircher, T. (author)

Klimes-Dougan, B. (author)

Krämer, B. (author)

Krug, A. (author)

Lagopoulos, J. (author)

Leenings, R. (author)

MacMaster, F. P. (author)

MacQueen, G. (author)

McIntosh, A. (author)

McLellan, Q. (author)

McMahon, K. L. (author)

Medland, S. E. (author)

Mueller, B. A. (author)

Mwangi, B. (author)

Osipov, E. (author)

Portella, M. J. (author)

Pozzi, E. (author)

Reneman, L. (author)

Repple, J. (author)

Rosa, P. G. P. (author)

Sacchet, M. D. (author)

Sämann, P. G. (author)

Schnell, K. (author)

Schrantee, A. (author)

Simulionyte, E. (author)

Soares, J. C. (author)

Sommer, J. (author)

Stein, D. J. (author)

Steinsträter, O. (author)

Strike, L. T. (author)

Thomopoulos, S. I. (author)

van Tol, M. J. (author)

Veer, I. M. (author): Karolinska Institutet

Vermeiren, R. R. J. M. (author)

Walter, H. (author)

van der Wee, N. J. A. (author)

van der Werff, S. J. A. (author)

Whalley, H. (author)

Winter, N. R. (author)

Wittfeld, K. (author)

Wright, M. J. (author)

Wu, M. J. (author)

Völzke, H. (author)

Yang, T. T. (author)

Zannias, V. (author)

de Zubicaray, G. I. (author)

Zunta-Soares, G. B. (author)

Abé, C. (author)

Alda, M. (author)

Andreassen, O. A. (author)

Bøen, E. (author)

Bonnin, C. M. (author)

Canales-Rodriguez, E. J. (author)

Cannon, D. (author)

Caseras, X. (author)

Chaim-Avancini, T. M. (author)

Elvsåshagen, T. (author)

Favre, P. (author)

Foley, S. F. (author)

Fullerton, J. M. (author)

Goikolea, J. M. (author)

Haarman, B. C. M. (author)

Hajek, T. (author)

Henry, C. (author)

Houenou, J. (author)

Howells, F. M. (author)

Ingvar, M. (author)

Kuplicki, R. (author)

Lafer, B. (author)

Landén, Mikael, 1966 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Machado-Vieira, R. (author)

Malt, U. F. (author)

McDonald, C. (author)

Mitchell, P. B. (author)

Nabulsi, L. (author)

Otaduy, M. C. G. (author)

Overs, B. J. (author)

Polosan, M. (author)

Pomarol-Clotet, E. (author)

Radua, J. (author)

Rive, M. M. (author)

Roberts, G. (author)

Ruhe, H. G. (author)

Salvador, R. (author)

Sarró, S. (author)

Satterthwaite, T. D. (author)

Savitz, J. (author)

Schene, A. H. (author)

Schofield, P. R. (author)

Serpa, M. H. (author)

Sim, K. (author)

Soeiro-de-Souza, M. G. (author)

Sutherland, A. N. (author)

Temmingh, H. S. (author)

Timmons, G. M. (author)

Uhlmann, A. (author)

Vieta, E. (author)

Wolf, D. H. (author)

Zanetti, M. V. (author)

Jahanshad, N. (author)

Thompson, P. M. (author)

Veltman, D. J. (author)

Penninx, B. W. J. H. (author)

Marquand, A. F. (author)

Cole, J. H. (author)

Schmaal, L. (author)

Thomopoulos, IT (author)

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(creator_code:org_t)

2020-05-18
2021
English.
In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26

Related links:: https://www.nature.c...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s).

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By the author/editor: Landén, Mikael, ...; Dinga, R.; Hahn, T.; Ching, C. R. K.; Eyler, L. T.; Aftanas, L.; show more...; Aghajani, M.; Aleman, A.; Baune, B. T.; Berger, K.; Brak, I.; Filho, G. B.; Carballedo, A.; Connolly, C. G.; Couvy-Duchesne, ...; Cullen, K. R.; Dannlowski, U.; Davey, C. G.; Dima, D.; Duran, F. L. S.; Enneking, V.; Filimonova, E.; Frenzel, S.; Frodl, T.; Fu, C. H. Y.; Godlewska, B. R.; Gotlib, I. H.; Grabe, H. J.; Groenewold, N. A ...; Grotegerd, D.; Gruber, O.; Hall, G. B.; Harrison, B. J.; Hatton, S. N.; Hermesdorf, M.; Hickie, I. B.; Ho, T. C.; Hosten, N.; Jansen, A.; Kähler, C.; Kircher, T.; Klimes-Dougan, B ...; Krämer, B.; Krug, A.; Lagopoulos, J.; Leenings, R.; MacMaster, F. P.; MacQueen, G.; McIntosh, A.; McLellan, Q.; McMahon, K. L.; Medland, S. E.; Mueller, B. A.; Mwangi, B.; Osipov, E.; Portella, M. J.; Pozzi, E.; Reneman, L.; Repple, J.; Rosa, P. G. P.; Sacchet, M. D.; Sämann, P. G.; Schnell, K.; Schrantee, A.; Simulionyte, E.; Soares, J. C.; Sommer, J.; Stein, D. J.; Steinsträter, O.; Strike, L. T.; Thomopoulos, S. ...; van Tol, M. J.; Veer, I. M.; Vermeiren, R. R. ...; Walter, H.; van der Wee, N. ...; van der Werff, S ...; Whalley, H.; Winter, N. R.; Wittfeld, K.; Wright, M. J.; Wu, M. J.; Völzke, H.; Yang, T. T.; Zannias, V.; de Zubicaray, G. ...; Zunta-Soares, G. ...; Abé, C.; Alda, M.; Andreassen, O. A ...; Bøen, E.; Bonnin, C. M.; Canales-Rodrigue ...; Cannon, D.; Caseras, X.; Chaim-Avancini, ...; Elvsåshagen, T.; Favre, P.; Foley, S. F.; Fullerton, J. M.; Goikolea, J. M.; Haarman, B. C. M ...; Hajek, T.; Henry, C.; Houenou, J.; Howells, F. M.; Ingvar, M.; Kuplicki, R.; Lafer, B.; Machado-Vieira, ...; Malt, U. F.; McDonald, C.; Mitchell, P. B.; Nabulsi, L.; Otaduy, M. C. G.; Overs, B. J.; Polosan, M.; Pomarol-Clotet, ...; Radua, J.; Rive, M. M.; Roberts, G.; Ruhe, H. G.; Salvador, R.; Sarró, S.; Satterthwaite, T ...; Savitz, J.; Schene, A. H.; Schofield, P. R.; Serpa, M. H.; Sim, K.; Soeiro-de-Souza, ...; Sutherland, A. N ...; Temmingh, H. S.; Timmons, G. M.; Uhlmann, A.; Vieta, E.; Wolf, D. H.; Zanetti, M. V.; Jahanshad, N.; Thompson, P. M.; Veltman, D. J.; Penninx, B. W. J ...; Marquand, A. F.; Cole, J. H.; Schmaal, L.; Thomopoulos, IT; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Molecular Psychi ...

By the university: University of Gothenburg; Karolinska Institutet

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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

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