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Sökning: WFRF:(Friberg Sven) > Övrigt vetenskapligt/konstnärligt

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1.
  • Asp, Petter, et al. (författare)
  • 25 kap. Om böter m.m.
  • 2018
  • Ingår i: Brottsbalken. - Stockholm : Karnov Group. - 9789176106686 ; , s. 1211-1231
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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2.
  • Asp, Petter, et al. (författare)
  • 25 kap. Om böter m.m.
  • 2018
  • Ingår i: Brottsbalken. - Stockholm : Karnov Group. - 9789176106686 ; , s. 1211-1231
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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3.
  • Asp, Petter, et al. (författare)
  • 26 kap. Om fängelse
  • 2018
  • Ingår i: Brottsbalken. - Stockholm : Karnov Group. - 9789176106686 ; , s. 1233-1276
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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4.
  • Bouchene, Salim, 1984-, et al. (författare)
  • A Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic (WBPBPK-PD) Model for Colistin in Critically Ill Patients
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Objectives: Colistin is used as a salvage therapy for multidrug-resistant Gram-negative bacterial infections and administered as a prodrug, colistimethate sodium (CMS). Characterizing distribution of colistin at the site of infection is important to optimize bacterial killing. The aims of this analysis were (i) to apply a whole-body physiologically based pharmacokinetic (WPBPK) model structure to describe the pharmacokinetics (PK) of CMS and colistin in critically ill patients and (ii) to predict colistin concentration-time courses and bacterial killing in target tissues combining the WBPBPK model with a semi-mechanistic pharmacokinetic-pharmacodynamic (PKPD) model.Methods: 27 critically ill patients treated with colistin were included in the analysis. A WBPBPK model previously developed in rat was applied to describe CMS and colistin PK data. The model was used to predict tissue concentrations in lungs, skin, blood and kidneys to drive a semi-mechanistic PKPD model on a wild-type (ATCC 27853) or a meropenem-resistant (AUR552) clinical strain P. aeruginosa to predict bacterial killing following the original dosing regimen and by replacing the original initial dose with a loading dose of 9MU.Results: The plasma data were reasonably well described by the WBPBPK model for both CMS and colistin with a slight overprediction at the 1st occasion.  High exposure was predicted in kidneys comparable to what had been predicted in previous studies, in rat and healthy subjects. Bacterial load was quickly cleared for both the ATCC 27853 and ARU552 strains in all tissues and at a higher extend in kidney tissue, for all dosing scenarios.Conclusion: The WPBPK model was able to adequately describe the PK of CMS and colistin in critically ill patients. The combination of the predicted PK profiles in tissues of interest with a PKPD model was able to predict the bactericidal effect of colistin at target sites.
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5.
  • Bouchene, Salim, 1984-, et al. (författare)
  • Application of a whole-body physiologically based pharmacokinetic model to describe the plasma and urine disposition of colistin and colistin methanesulfonate (CMS) in healthy volunteers
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Objectives: The primary aim of this work was to develop a whole-body physiologically based pharmacokinetic (WBPBPK) model to describe CMS and colistin disposition in human plasma and urine. The secondary aim of this analysis was to use the WBPBPK model to predict CMS and colistin tissue distribution in typical individuals with different pathophysiological changes and receiving different dosing regimens.Methods: Twelve healthy males were included in the analysis. They received a single dose of 80 mg CMS (1 million unit) through a 1-h intravenous infusion. Venous blood was collected between 0 and 18 h post dose. Fractionated urine samples were collected between 0 and 24 h after dose. A WBPBPK model initially developed in rat was further detailed with the addition of a specific urinary tract (UT) model. The Kp values of CMS and colistin were estimated for all tissues using experimental Kp prior values from rat tissue homogenates.Results: The model adequately described CMS and colistin concentrations over time in plasma and in urine. A shared first order elimination rate constant was estimated to depict the hydrolysis of CMS in plasma and tissues. A separate hydrolysis rate constant for CMS was estimated in urine, and was lower than in plasma and tissues. A shared non-renal elimination rate constant of colistin was estimated in plasma and in tissues. CMS and colistin disposition in urine was well characterized by the UT model. The tubular reabsorption of colistin was best described by a saturable model estimating the colistin affinity constant, KM. Non-specific binding of colistin in the UT lumen was accounted for using a linear relationship.Conclusion: The WBPBPK developed in this study characterized plasma and urine PK of CMS and colistin in human well. This model was used as a new framework to predict colistin exposure in the tissues of interest under different physiological conditions. The model can be easily refined when new data are available and can be combined to PKPD models to increase the understanding of the concentration-effect relationship at target sites.
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6.
  • Bouchene, Salim, 1984-, et al. (författare)
  • Development of an interspecies whole-body physiologically based pharmacokinetic (WBPBPK) model for colistin methanesulfonate (CMS) and colistin in five animal species and evaluation of its predictive ability in human
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Background and purposeColistin is a last-line antibiotic administered as the prodrug colistin methanesulfonate (CMS) for the treatment of multidrug resistant Gram-negative bacterial infections. Whole-body physiologically based pharmacokinetic (WBPBPK) models are valuable tools to understand and characterize drug disposition, predict tissue distribution and interpret exposure-response relationship. The aim of this work was to develop a WBPBPK model for colistin and CMS in five animal species and evaluate the utility of the model for predicting colistin and CMS disposition in human.MethodsA nonlinear mixed-effects WBPBPK model previously developed in rats was extended to describe CMS and colistin plasma data of animals from 5 different species (40 mice, 6 rats, 3 rabbits, 3 baboons and 2 pigs) that had received single doses of CMS. CMS renal clearance and hydrolysis to colistin were allometrically scaled based on glomerular filtration rate (GFR) and tissue volumes, respectively. For the non-renal colistin clearance, three scaling models were evaluated: volume based allometric scaling, volume and maximum lifespan potential (MLP) based allometric scaling, and estimation of specie-specific parameters. Tissue concentrations were predicted for all species. The WBPBPK model was then used to predict human plasma concentrations, which were compared to observed human plasma PK data extracted from literature.ResultsThe description of the plasma PK of CMS and colistin in mice, rats, rabbits, baboons and pigs was satisfactory. The volume and MLP based allometric scaling of the non-renal clearance of colistin was best at characterizing colistin concentration-time course, even if a misprediction remained in pigs. In human however, allometric scaling without MLP was closest to the observed data, with satisfactory prediction of the CMS plasma profiles and a slight overprediction of colistin plasma PK profiles.ConclusionsInterspecies WBPBPK models were developed to describe the disposition of CMS and colistin across five animal species and human plasma concentrations of CMS and colistin were predicted in the right ranges.
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10.
  • Friberg, Ulf, 1962- (författare)
  • Den kapitalistiska skådespelaren : Aktör eller leverantör?
  • 2014
  • Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
    • The dissertation revolves around an actor’s craft as a changing craft. Theatre workers– like many other professions in Sweden – have experienced major changes in thelabour market during a relatively short period of time. In what way has capitalisticideology changed society over the last 25 years, and in what way has this affected theactor’s craft, and what impact has been experienced? What strategies can the field ofthe theatre, in general, and the actors, in particular, use to create space for the developmentof the craft of acting in a new era?The different parts of the dissertation attack the questions mentioned above from anumber of different angles. References from other disciplines such as philosophy, thehistory of ideas and sociology, which are placed in dialogue with the theatre in thisdissertation project, are all-important.In the first part of the dissertation, the author positions the research and himselfand also presents the methods used and the theories from other disciplines throughwhich he discusses the issues to be addressed.The next section discusses leadership and organisation through the 1990’s until today.The economic crises that affected Sweden during this time not only producedfairly extensive changes for publicly funded theatres but also brought about a changingbalance of power in theatres.Theatrical craft is discussed in the next section, where the main questions addressedare: In what way do changes in power relations affect the actor’s craft? What is theactor’s craft and who is really portraying the role? Actors in fact need what the authorwould like to call “informal power” in relation to their craft; however, this informalspace, the author argues, has been cut back.The fourth act in this dissertation consists of the text of a play, which adopts a freerand more associative approach to the issues discussed, and, as part of the discussion,is staged in a publicly funded theatre in connection with the actual public defence ofthe dissertation.The Epilogue carries and drives issues towards a changing future – if this futureexists.
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