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Sökning: WFRF:(Fridberg Marie) > Nordin Fredrikson Gunilla > Higher intensity of...

Higher intensity of low molecular weight protein tyrosine phosphatase/ ACP-1 in survivors of patients diagnosed with diffuse large B cell lymphoma (DLBCL) compared to non-survivors

Stanezai, Sanga (författare)
Malmö University
Sahlén, Elisabeth (författare)
Malmö University
El-Schich, Zahra (författare)
Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
visa fler...
Fridberg, Marie (författare)
Learning in Science and Mathematics (LISMA),LISMA
Nordin Fredrikson, Gunilla (författare)
Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Lund University
Anagnostaki, Lola (författare)
Skane University Hospital,Skånes universitetssjukhus
Tassidis, Helena (författare)
Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Man and Biosphere Health (MABH)
Persson, Jenny L (författare)
Lund University
Wingren, Anette Gjörloff (författare)
Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö University
visa färre...
 (creator_code:org_t)
Austin Publishing, 2016
2016
Engelska.
Ingår i: Austin Biology. - : Austin Publishing. ; 1:2:2
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Adult diffuse large B cell lymphoma (DLBCL) is a heterogeneous form of hematopoietic cancer and difficult to treat. In order to find a better diagnostic indication for the disease, we analyzed low molecular weight protein tyrosine phosphatase (LMWPTP) that in humans is encoded by the ACP1 gene. LMWPTP is an enzyme shown to counteract protein tyrosine kinases (PTK) and was suggested to be a negative growth factor regulator. However, the 18 kDa PTP can also have a positive effect on cell growth and proliferation, indicating a controversial role in the tumorigenic process. LMWPTP exists in different isoforms which are electrophoretically, kinetically and immunologically distinct. We have studied two subgroups of DLBCL consisting of a germinal center B cell like (GCB) and a non-germinal center B cell like (non-GCB) group. The two subgroups have been defined by gene-expressing profiling and are associated with differential outcome. The expression levels of LMWPTP protein was compared and showed significant differences between the GCB and non-GCB subgroups (p=0.012). Interestingly, when the samples were divided into survivors and non-survivors, and thereafter analyzed for LMWPTP expression, the samples from patients with a higher survival rate showed increased staining intensity, whereas the samples from patients with lower intensity of LMWPTP did not survive the disease (p=0.001). In conclusion, we have shown that DLBCL patients with worse outcome express LMWPTP with a lower intensity, suggesting a tumor suppressor role for this form of the enzyme.

Ämnesord

LANTBRUKSVETENSKAPER  -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
AGRICULTURAL SCIENCES  -- Veterinary Science -- Medical Bioscience (hsv//eng)

Nyckelord

ACP1
B-cell
DLBCL
germinal center
LMWPTP
lymphoma
non-germinal center
prognosis

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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