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- Vandenput, Liesbeth, 1974, et al.
(författare)
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Update of the fracture risk prediction tool FRAX : a systematic review of potential cohorts and analysis plan
- 2022
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Ingår i: Osteoporosis International. - : Springer. - 0937-941X .- 1433-2965. ; 33:10, s. 2103-2136
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Forskningsöversikt (refereegranskat)abstract
- Summary: We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.Introduction: The availability of the fracture risk assessment tool FRAX® has substantially enhanced the targeting of treatment to those at high risk of fracture with FRAX now incorporated into more than 100 clinical osteoporosis guidelines worldwide. The aim of this study is to determine whether the current algorithms can be further optimised with respect to current and novel risk factors.Methods: A computerised literature search was performed in PubMed from inception until May 17, 2019, to identify eligible cohorts for updating the FRAX coefficients. Additionally, we searched the abstracts of conference proceedings of the American Society for Bone and Mineral Research, European Calcified Tissue Society and World Congress of Osteoporosis. Prospective cohort studies with data on baseline clinical risk factors and incident fractures were eligible.Results: Of the 836 records retrieved, 53 were selected for full-text assessment after screening on title and abstract. Twelve cohorts were deemed eligible and of these, 4 novel cohorts were identified. These cohorts, together with 60 previously identified cohorts, will provide the resource for constructing an updated version of FRAX comprising 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. For each known and candidate risk factor, multivariate hazard functions for hip fracture, major osteoporotic fracture and death will be tested using extended Poisson regression. Sex- and/or ethnicity-specific differences in the weights of the risk factors will be investigated. After meta-analyses of the cohort-specific beta coefficients for each risk factor, models comprising 10-year probability of hip and major osteoporotic fracture, with or without femoral neck bone mineral density, will be computed.Conclusions: These assembled cohorts and described models will provide the framework for an updated FRAX tool enabling enhanced assessment of fracture risk (PROSPERO (CRD42021227266)).
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- Richards, Stephen, et al.
(författare)
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The genome of the model beetle and pest Tribolium castaneum.
- 2008
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Ingår i: Nature. - 1476-4687. ; 452:7190, s. 949-55
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Tidskriftsartikel (refereegranskat)abstract
- Tribolium castaneum is a representative of earth’s most numerous eukaryotic order, a powerful model organism for the study of generalized insect development, and also an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved an ability to interact with a diverse chemical environment as evidenced by large expansions in odorant and gustatory receptors, as well as p450 and other detoxification enzymes. Developmental patterns in Tribolium are more representative of other arthropods than those found in Drosophila, a fact represented in gene content and function. For one, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, and some are expressed in the growth zone crucial for axial elongation in short germ development. Systemic RNAi in T. castaneum appears to use mechanisms distinct from those found in C. elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
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- Kero, J., et al.
(författare)
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MU radar head echo observations of the 2011 October Draconids
- 2012
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Ingår i: Monthly notices of the Royal Astronomical Society. - Hoboken, NJ : Wiley-Blackwell. - 0035-8711 .- 1365-2966. ; 424:3, s. 1799-1806
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Tidskriftsartikel (refereegranskat)abstract
- On 2011 October 8, the Earth passed through a stream of dust ejected by the comet 21P/GiacobiniZinner during its perihelion passage of the year 1900, causing an outburst of October Draconid meteors. 13 Draconids were observed among similar to 6300 meteor head echoes with precisely determined orbits during an observational campaign ranging from October 8 05:00 ut to October 9 13:00 ut with the Shigaraki middle and upper atmosphere (MU) radar in Japan (34 degrees.85?N and 136 degrees.10?E). The meteor outburst occurred while the Draconid radiant was descending below and 2?h later rising up above the horizon. Therefore, 11 of the detections were from very low (<15 degrees) elevation. The detection altitudes of the Draconids were high compared to sporadic meteors of the same velocity and radiant elevation. The weighted mean geocentric velocity of the 13 Draconids was 20.6 +/- 0.4?km?s-1, and the weighted mean radiant located at right ascension alpha = 263 degrees.3 +/- 0 degrees.6 and declination delta = 55 degrees.8 +/- 0 degrees.2.
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- Kero, J., et al.
(författare)
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The 2009-2010 MU radar head echo observation programme for sporadic and shower meteors : radiant densities and diurnal rates
- 2012
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Ingår i: Monthly notices of the Royal Astronomical Society. - Hoboken, NJ : Wiley-Blackwell. - 0035-8711 .- 1365-2966. ; 425:1, s. 135-146
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this paper is to give an overview of the monthly meteor head echo observations (528.8?h) conducted between 2009 June and 2010 December using the Shigaraki Middle and Upper atmosphere radar in Japan (34 degrees.85 N, 136 degrees.10 E). We present diurnal detection rates and radiant density plots from 18 separate observational campaigns, each lasting for at least one diurnal cycle. Our data comprise more than 106?000 meteors. All six recognized apparent sporadic meteor sources are discernable and their average orbital distributions are presented in terms of geocentric velocity, semimajor axis, inclination and eccentricity. The north and south apex have radiant densities an order of magnitude higher than other apparent source regions. The diurnal detection rates show clear seasonal dependence. The main cause of the seasonal variation is the tilt of the Earth's axis, causing the elevation of the Earth's apex above the local horizon to change as the Earth revolves around the Sun. Yet, the meteor rate variation is not symmetric with respect to the equinoxes. When comparing the radiant density at different times of the year, and thus at different solar longitudes along the Earth's orbit, we have found that the north and south apex source regions fluctuate in strength.
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