| 1. |
- Davids, W., et al.
(författare)
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The journey to smORF-land
- 2003
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Ingår i: Comparative and Functional Genomics. ; 4, s. 537-541
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Davids, W., et al.
(författare)
-
The journey to smORFland.
- 2003
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Ingår i: Comp Funct Genom. ; 4:5, s. 537-541
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Darby, Alistair C., et al.
(författare)
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Intracellular pathogens go extreme: genome evolution in the Rickettsiales
- 2007
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Ingår i: Trends in Genetics. - : Elsevier BV. - 0168-9525 .- 1362-4555. ; 23:10, s. 511-520
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Forskningsöversikt (refereegranskat)abstract
- The Rickettsiales, a genetically diverse group of the α-Proteobacteria, include major mammalian pathogens, such as the agents of epidemic typhus, scrub typhus, ehrlichioses and heartwater disease. Sequenced genomes of this bacterial order have provided exciting insights into reductive genome evolution, antigenic variation and host cell manipulation. Recent results suggest that human pathogens emerged relatively late in the evolution of the Rickettsiales. Surprisingly, there is no association between pathogenicity and the acquisition of novel virulence genes. Here, we explore the genomic differences between members of the Rickettsiales and ask what are the changes that enable infectious agents to emerge from seemingly harmless bacteria.
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| 4. |
- Fuxelius, Hans-Henrik, et al.
(författare)
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Visualization of pseudogenes in intracellular bacteria reveals the different tracks to gene destruction
- 2008
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 9:2, s. R42-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Pseudogenes reveal ancestral gene functions. Some obligate intracellular bacteria, such as Mycobacterium leprae and Rickettsia spp., carry substantial fractions of pseudogenes. Until recently, horizontal gene transfers were considered to be rare events in obligate host-associated bacteria. Results: We present a visualization tool that displays the relationships and positions of degraded and partially overlapping gene sequences in multiple genomes. With this tool we explore the origin and deterioration patterns of the Rickettsia pseudogenes and find that variably present genes and pseudogenes tend to have been acquired more recently, are more divergent in sequence, and exhibit a different functional profile compared with genes conserved across all species. Overall, the origin of only one-quarter of the variable genes and pseudogenes can be traced back to the common ancestor of Rickettsia and the outgroup genera Orientia and Wolbachia. These sequences contain only a few disruptive mutations and show a broad functional distribution profile, much like the core genes. The remaining genes and pseudogenes are extensively degraded or solely present in a single species. Their functional profile was heavily biased toward the mobile gene pool and genes for components of the cell wall and the lipopolysaccharide. Conclusion: Reductive evolution of the vertically inherited genomic core accounts for 25% of the predicted genes in the variable segments of the Rickettsia genomes, whereas 75% stems from the flux of the mobile gene pool along with genes for cell surface structures. Thus, most of the variably present genes and pseudogenes in Rickettsia have arisen from recent acquisitions.
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