B-type natriuretic peptide plasma levels are elevated in subcortical vascular dementia.

• High levels of B-type natriuretic peptide (BNP), a serum marker of congestive heart failure, are associated with an increased risk for cognitive decline. However, no study has yet assessed this marker in different subtypes of dementia. We tested the hypothesis that BNP has a more significant association with vascular dementia than Alzheimer disease. Plasma BNP was measured in 15 patients with subcortical vascular dementia, in 19 Alzheimer patients without evidence of vascular comorbidity, and in age-matched controls. Compared with controls (28+/-7 ng/l), BNP was elevated in subcortical vascular dementia (63+/-17 ng/l; P=0.03), but not in Alzheimer disease (36+/-5 ng/l). In conclusion, subcortical vascular dementia is indeed associated with moderately elevated BNP levels, whereas this could not be shown for Alzheimer disease. This probably reflects the larger cardiovascular burden in patients with subcortical vascular dementia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Aged

Alzheimer Disease

blood

diagnosis

physiopathology

Biological Markers

analysis

blood

Brain

blood supply

metabolism

physiopathology

Brain Ischemia

etiology

pathology

physiopathology

Causality

Cerebral Arteries

pathology

physiopathology

Cerebrovascular Circulation

physiology

Comorbidity

Dementia

Vascular

blood

etiology

physiopathology

Heart Failure

blood

complications

physiopathology

Humans

Natriuretic Peptide

Brain

analysis

blood

Predictive Value of Tests

Up-Regulation

physiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)