Sökning: WFRF:(Galter Dagmar)
> Teknik >
An organic electron...
An organic electronic biomimetic neuron enable sauto-regulated neuro modulation
-
- Simon, Daniel (författare)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,Karolinska Institute, Sweden; Karolinska Institute, Sweden,Karolinska Institute, Sweden; Linköping University, Sweden
-
- Larsson, Karin C. (författare)
- Karolinska Institute, Sweden; Karolinska Institute, Sweden
-
- Nilsson, David (författare)
- RISE,Acreo,Acreo Swedish ICT AB, Sweden
-
visa fler...
-
- Burström, Gustav (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
-
- Galter, Dagmar (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
-
- Berggren, Magnus (författare)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,Linköping University, Sweden
-
- Richter-Dahlfors, Agneta (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
-
Ingår i: Biosensors & bioelectronics. - : Elsevier BV. - 0956-5663 .- 1873-4235. ; 71, s. 359-364
- Relaterad länk:
-
http://liu.diva-port...
-
visa fler...
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Current therapies for neurological disorders are based on traditional medication and electric stimulation. Here, we present an organic electronicbiomimetic neuron, with the capacity to precisely intervene with the underlying malfunctioning signalling pathway using endogenous substances. The fundamental function of neurons, defined as chemical-to-electrical-to-chemical signal transduction, is achieved by connecting enzyme-based amperometric biosensors and organic electronic ion pumps. Selective biosensors transduce chemical signals into an electric current, which regulates electrophoretic delivery of chemical substances without necessitating liquid flow. Biosensors detected neurotransmitters in physiologically relevant ranges of 5–80 µM, showing linear response above 20 µm with approx. 0.1 nA/µM slope. When exceeding defined threshold concentrations, biosensor output signals, connected via custom hardware/software, activated local or distant neurotransmitter delivery from the organic electronic ion pump. Changes of 20 µM glutamate or acetylcholinetriggered diffusive delivery of acetylcholine, which activated cells via receptor-mediated signalling. This was observed in real-time by single-cell ratiometric Ca2+ imaging. The results demonstrate the potential of the organic electronic biomimetic neuron in therapies involving long-range neuronal signalling by mimicking the function of projection neurons. Alternatively, conversion of glutamate-induced descending neuromuscular signals into acetylcholine-mediated muscular activation signals may be obtained, applicable for bridging injured sites and active prosthetics.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
Nyckelord
- chronic pain
- organic electronics
- ionpump
- biosensors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas