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- Gasior, P., et al.
(författare)
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Effective laser-induced removal of co-deposited layers from plasma-facing components in a tokamak
- 2006
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Ingår i: Czechoslovak Journal of Physics. - : Springer Science and Business Media LLC. - 0011-4626 .- 1572-9486. ; 56, s. B67-B72
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Tidskriftsartikel (refereegranskat)abstract
- An experimental set-up and spectroscopy diagnostic method for laser-induced fuel removal and decomposition of co-deposited layers on plasma-facing components from tokamaks are described. For irradiation of a graphite limiter tile from the TEXTOR tokamak Nd:YAG 3.5-ns pulse laser with a repetition rate of 10 Hz and single pulse energy of up to 0,8 J at 1,06 mu m has been used. The spectroscopy system allowed recording of spectra in the visible wavelength range including CII and D alpha spectral lines. The evolution of CII and Da spectral lines was observed pulse-by-pulse during the co-deposit removal. The efficient ablation of the 45 mu m thick co-deposit occured after approximately 50 laser pulses.
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- Lyons, PA, et al.
(författare)
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Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 5120-
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Tidskriftsartikel (refereegranskat)abstract
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA.
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